Isochorismate synthase entC (P0AEJ2)

Identification
Name:Isochorismate synthase entC
Synonyms:
  • Isochorismate mutase
Gene Name:entC
Enzyme Class:
Biological Properties
General Function:Involved in biosynthetic process
Specific Function:Chorismate = isochorismate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Biosynthesis of siderophore group nonribosomal peptides ec01053
  • Metabolic pathways eco01100
  • Ubiquinone and other terpenoid-quinone biosynthesis ec00130
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Chorismate ↔ 1.0Isochorismate
ReactionCard
SMPDB Reactions:
1.0Thumb → 1.0isochorismate+1.0Thumb
1.0Chorismate → 1.0isochorismate + 1.0Isochorismate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Chorismate ↔ 1.0Isochorismate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0Chorismate → 1.0Isochorismate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB12199ChorismateMetaboCard
ECMDB20162IsochorismateMetaboCard
GO Classification:
Function
catalytic activity
intramolecular transferase activity
intramolecular transferase activity, transferring hydroxy groups
isochorismate synthase activity
isomerase activity
Process
biosynthetic process
metabolic process
Gene Properties
Blattner:b0593
Gene OrientationClockwise
Centisome Percentage:13.45
Left Sequence End624108
Right Sequence End625283
Gene Sequence:
>1176 bp
ATGGATACGTCACTGGCTGAGGAAGTACAGCAGACCATGGCAACACTTGCGCCCAATCGC
TTTTTCTTTATGTCGCCGTACCGCAGTTTTACGACGTCAGGATGTTTCGCCCGCTTCGAT
GAACCGGCTGTGAACGGGGATTCGCCCGACAGTCCCTTCCAGCAAAAACTCGCCGCGCTG
TTTGCCGATGCCAAAGCGCAGGGCATCAAAAATCCGGTGATGGTCGGGGCGATTCCCTTC
GATCCACGTCAGCCTTCGTCGCTGTATATTCCTGAATCCTGGCAGTCGTTCTCCCGTCAG
GAAAAACAAGCTTCCGCACGCCGTTTCACCCGCAGCCAGTCGCTGAATGTGGTGGAACGC
CAGGCAATTCCGGAGCAAACCACGTTTGAACAGATGGTTGCCCGCGCCGCCGCACTTACC
GCCACGCCGCAGGTCGACAAAGTGGTGTTGTCACGGTTGATTGATATCACCACTGACGCC
GCCATTGATAGTGGCGTATTGCTGGAACGGTTGATTGCGCAAAACCCGGTTAGTTACAAC
TTCCATGTTCCGCTGGCTGATGGTGGCGTCCTGCTGGGGGCCAGCCCGGAACTGCTGCTA
CGTAAAGACGGCGAGCGTTTTAGCTCCATTCCGTTAGCCGGTTCCGCGCGTCGTCAGCCG
GATGAAGTGCTCGATCGCGAAGCAGGTAATCGTCTGCTGGCGTCAGAAAAAGATCGCCAT
GAACATGAACTGGTGACTCAGGCGATGAAAGAGGTACTGCGCGAACGCAGTAGTGAGTTA
CACGTTCCTTCTTCTCCACAGCTGATCACCACGCCGACGCTGTGGCATCTCGCAACTCCC
TTTGAAGGTAAAGCGAATTCGCAAGAAAACGCACTGACTCTGGCCTGTCTGCTGCATCCG
ACCCCCGCGCTGAGCGGTTTCCCGCATCAGGCCGCGACCCAGGTTATTGCTGAACTGGAA
CCGTTCGACCGCGAACTGTTTGGCGGCATTGTGGGTTGGTGTGACAGCGAAGGTAACGGC
GAATGGGTGGTGACCATCCGCTGCGCGAAGCTGCGGGAAAATCAGGTGCGTCTGTTTGCC
GGAGCGGGGATTGTGCCTGCGTCGTCACCGTTGGGTGAGTGGCGCGAAACAGGCGTCAAA
CTTTCTACCATGTTGAACGTTTTTGGATTGCATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:391
Protein Molecular Weight:42931
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Isochorismate synthase entC
MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAAL
FADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVER
QAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYN
FHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRH
EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHP
TPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFA
GAGIVPASSPLGEWRETGVKLSTMLNVFGLH
References
External Links:
ResourceLink
Uniprot ID:P0AEJ2
Uniprot Name:ENTC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674714
Ecogene ID:EG10261
Ecocyc:EG10261
ColiBase:b0593
Kegg Gene:b0593
EchoBASE ID:EB0257
CCDB:ENTC_ECOLI
BacMap:16128576
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Brickman, T. J., Ozenberger, B. A., McIntosh, M. A. (1990). "Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli." J Mol Biol 212:669-682. Pubmed: 2139473
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Liu, J., Quinn, N., Berchtold, G. A., Walsh, C. T. (1990). "Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate." Biochemistry 29:1417-1425. Pubmed: 2139795
  • Ozenberger, B. A., Brickman, T. J., McIntosh, M. A. (1989). "Nucleotide sequence of Escherichia coli isochorismate synthetase gene entC and evolutionary relationship of isochorismate synthetase and other chorismate-utilizing enzymes." J Bacteriol 171:775-783. Pubmed: 2536681
  • Saravani, G. A., Martin, D. R. (1990). "Opacity factor from group A streptococci is an apoproteinase." FEMS Microbiol Lett 56:35-39. Pubmed: 2110093