Putative peroxiredoxin bcp (P0AE52)

Identification
Name:Putative peroxiredoxin bcp
Synonyms:
  • Bacterioferritin comigratory protein
  • Thioredoxin reductase
Gene Name:bcp
Enzyme Class:
Biological Properties
General Function:Involved in antioxidant activity
Specific Function:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
2.0Thiol-containing reductant+1.0ROOH ↔ 1.0Oxidized thiol-containing reductant+1.0Thumb+1.0ROH
2.0Thiol-containing reductant + 1.0ROOH ↔ 1.0Oxidized thiol-containing reductant + 1.0Water + 1.0ROH
ReactionCard
Complex Reactions:
1.0Thumb+1.0Reduced Thioredoxin → 2.0Thumb+1.0Oxidized Thioredoxin
1.0Hydrogen peroxide + 1.0Reduced Thioredoxin → 2.0Water + 1.0Oxidized Thioredoxin
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21232Hydrogen peroxideMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
antioxidant activity
catalytic activity
oxidoreductase activity
Process
cell redox homeostasis
cellular homeostasis
cellular process
Gene Properties
Blattner:b2480
Gene OrientationClockwise
Centisome Percentage:56.01
Left Sequence End2598500
Right Sequence End2598970
Gene Sequence:
>471 bp
ATGATTCAGTCACAAATTAACCGCAATATTCGTCTTGATCTTGCCGATGCCATTTTGCTC
AGCAAAGCTAAAAAAGATCTCTCATTTGCCGAGATTGCCGACGGCACCGGTCTGGCAGAA
GCCTTTGTAACCGCGGCTTTGCTGGGTCAGCAGGCGCTTCCTGCCGACGCCGCCCGCCTG
GTCGGGGCGAAGCTGGATCTCGACGAAGACTCCATTCTACTGTTGCAGATGATTCCACTG
CGTGGCTGCATTGATGACCGTATTCCAACTGACCCAACGATGTATCGTTTCTATGAAATG
TTGCAGGTGTACGGTACAACCCTGAAAGCGTTGGTTCATGAGAAATTTGGCGATGGCATT
ATTAGCGCGATTAACTTCAAACTCGACGTTAAGAAAGTGGCGGACCCGGAAGGTGGCGAA
CGTGCGGTCATCACCTTAGATGGTAAATATCTGCCGACCAAACCGTTCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:156
Protein Molecular Weight:17634
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Putative peroxiredoxin bcp
MNPLKAGDIAPKFSLPDQDGEQVNLTDFQGQRVLVYFYPKAMTPGCTVQACGLRDNMDEL
KKAGVDVLGISTDKPEKLSRFAEKELLNFTLLSDEDHQVCEQFGVWGEKSFMGKTYDGIH
RISFLIDADGKIEHVFDDFKTSNHHDVVLNWLKEHA
References
External Links:
ResourceLink
Uniprot ID:P0AE52
Uniprot Name:BCP_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674482
Ecogene ID:EG10108
Ecocyc:EG10108
ColiBase:b2480
Kegg Gene:b2480
EchoBASE ID:EB0106
CCDB:BCP_ECOLI
BacMap:16130405
General Reference:
  • Andrews, S. C., Harrison, P. M., Guest, J. R. (1991). "A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map." J Gen Microbiol 137:361-367. Pubmed: 2016588
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Ghrist, A. C., Stauffer, G. V. (1998). "Promoter characterization and constitutive expression of the Escherichia coli gcvR gene." J Bacteriol 180:1803-1807. Pubmed: 9537378
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Jeong, W., Cha, M. K., Kim, I. H. (2000). "Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family." J Biol Chem 275:2924-2930. Pubmed: 10644761
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837