Identification |
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Name: | Glycogen phosphorylase |
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Synonyms: | Not Available |
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Gene Name: | glgP |
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Enzyme Class: | |
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Biological Properties |
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General Function: | Involved in phosphorylase activity |
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Specific Function: | Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties |
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Cellular Location: | Not Available |
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SMPDB Pathways: | |
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KEGG Pathways: | |
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KEGG Reactions: | | | |
1.0 | ↔ | 1.0 |
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SMPDB Reactions: | |
1.0 | + | 1.0 | → | 1.0Alpha-D-glucose 1-phosphate | + | 1.0Dextrin | + | 1.0 |
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Complex Reactions: | |
1.0branching glycogen | + | 1.0 | → | 1.0 |
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Metabolites: | |
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GO Classification: | Function |
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binding | catalytic activity | cofactor binding | phosphorylase activity | pyridoxal phosphate binding | transferase activity | transferase activity, transferring glycosyl groups | transferase activity, transferring hexosyl groups | Process |
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carbohydrate metabolic process | metabolic process | primary metabolic process |
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Gene Properties |
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Blattner: | b3428 |
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Gene Orientation | Counterclockwise |
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Centisome Percentage: | 76.78 |
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Left Sequence End | 3562157 |
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Right Sequence End | 3564604 |
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Gene Sequence: | >2448 bp
ATGAATGCTCCGTTTACATATTCATCGCCCACGCTTAGCGTAGAAGCTCTTAAGCACTCT
ATCGCTTACAAGCTGATGTTTACGATTGGAAAGGACCCGGTCGTCGCCAATAAACATGAA
TGGCTGAACGCAACGTTATTTGCTGTGCGCGATCGTCTCGTGGAGCGCTGGTTACGTTCA
AACCGTGCCCAGTTGTCGCAAGAAACTCGTCAGGTTTACTACCTGTCGATGGAGTTTTTG
ATTGGCCGTACGCTCTCCAACGCCATGTTGTCGCTAGGAATTTACGAAGATGTACAGGGC
GCACTGGAAGCGATGGGGTTAAATCTCGAAGAGCTGATTGATGAAGAAAATGACCCAGGC
CTCGGTAACGGTGGCCTGGGACGTCTGGCGGCTTGCTTCCTTGATTCTCTGGCGACGTTA
GGGTTGCCGGGGCGCGGTTACGGCATCCGCTATGACTACGGTATGTTCAAGCAGAACATC
GTTAACGGTAGCCAGAAAGAGTCGCCAGACTACTGGCTGGAATACGGTAACCCGTGGGAA
TTCAAACGCCACAACACGCGCTATAAAGTCCGTTTTGGCGGTCGCATTCAGCAGGAAGGT
AAAAAAACGCGCTGGATTGAAACCGAAGAGATTCTGGGAGTCGCTTACGATCAGATAATC
CCTGGTTACGACACCGACGCGACCAACACGCTGCGTTTGTGGAGTGCGCAAGCCAGTAGC
GAAATTAACCTCGGTAAATTCAACCAGGGTGACTACTTCGCGGCAGTGGAAGATAAAAAC
CACTCCGAGAACGTATCTCGCGTACTGTATCCGGATGACTCCACCTACTCCGGGCGTGAG
CTGCGCCTGCGTCAGGAATACTTCCTGGTTTCCTCGACCATTCAGGACATTTTAAGCCGC
CATTATCAGTTGCATAAAACCTACGATAACCTGGCGGATAAAATCGCGATTCATCTCAAT
GATACCCATCCGGTACTGTCGATTCCTGAGATGATGCGTCTGCTGATCGATGAGCACCAA
TTTAGCTGGGACGACGCGTTTGAGGTGTGTTGTCAGGTCTTCTCCTACACTAACCACACG
CTGATGAGCGAGGCGCTGGAAACCTGGCCGGTTGATATGCTGGGTAAAATTCTGCCGCGT
CACCTGCAGATCATCTTTGAAATCAACGACTATTTCCTGAAAACCTTGCAGGAACAGTAT
CCGAACGATACCGATCTGCTGGGACGGGCGTCGATCATTGATGAATCCAACGGTCGTCGT
GTGCGTATGGCCTGGCTGGCGGTTGTTGTGAGCCACAAAGTTAACGGTGTATCGGAACTG
CACTCTAATCTGATGGTGCAATCGTTGTTTGCCGACTTTGCGAAAATCTTCCCGGGTCGT
TTCACCAACGTCACCAACGGTGTGACGCCGCGTCGCTGGCTGGCGGTAGCGAACCCATCG
CTTTCAGCCGTGCTGGACGAACACCTGGGCCGTAACTGGCGCACCGACCTTAGCCTGCTT
AATGAGCTGCAACAACACTGTGATTTCCCAATGGTTAATCACGCTGTGCATCAGGCGAAG
CTGGAGAACAAAAAGCGTCTGGCAGAGTATATCGCCCAGCAGCTGAATGTGGTGGTGAAT
CCAAAGGCGTTGTTCGATGTACAAATCAAACGTATTCACGAATACAAACGTCAATTGATG
AATGTGTTGCATGTGATTACCCGCTATAACCGCATCAAGGCCGACCCGGATGCGAAGTGG
GTACCGCGCGTGAATATTTTTGGCGGTAAGGCGGCTTCGGCCTATTACATGGCGAAGCAC
ATTATTCATTTGATCAATGACGTAGCGAAAGTGATCAACAACGATCCGCAGATTGGCGAT
AAGCTGAAAGTCGTGTTCATCCCGAACTACAGCGTTAGCCTGGCGCAGTTGATCATTCCG
GCGGCAGATCTGTCTGAACAGATTTCGCTGGCAGGGACGGAAGCTTCCGGCACCAGTAAC
ATGAAGTTTGCGCTTAACGGTGCGCTGACTATCGGTACGTTGGACGGTGCGAATGTCGAG
ATGCTGGATCATGTCGGTGCTGACAATATCTTTATTTTTGGTAACACAGCGGAAGAAGTG
GAAGAACTGCGTCGTCAGGGCTACAAACCGCGTGAATACTACGAGAAAGATGAGGAGCTG
CATCAGGTGCTGACGCAAATCGGCAGCGGTGTATTCAGTCCGGAAGATCCGGGTCGCTAT
CGCGATCTGGTTGATTCGCTGATCAACTTCGGCGATCACTACCAGGTACTGGCGGATTAT
CGCAGCTATGTCGATTGTCAGGATAAAGTCGATGAACTCTACGAGCTTCAGGAAGAGTGG
ACCGCAAAAGCGATGCTGAACATTGCCAATATGGGCTACTTCTCTTCTGACCGTACTATC
AAAGAGTACGCCGATCATATCTGGCATATCGATCCGGTGAGATTGTAA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 815 |
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Protein Molecular Weight: | 93172 |
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Protein Theoretical pI: | 6 |
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Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >Glycogen phosphorylase
MNAPFTYSSPTLSVEALKHSIAYKLMFTIGKDPVVANKHEWLNATLFAVRDRLVERWLRS
NRAQLSQETRQVYYLSMEFLIGRTLSNAMLSLGIYEDVQGALEAMGLNLEELIDEENDPG
LGNGGLGRLAACFLDSLATLGLPGRGYGIRYDYGMFKQNIVNGSQKESPDYWLEYGNPWE
FKRHNTRYKVRFGGRIQQEGKKTRWIETEEILGVAYDQIIPGYDTDATNTLRLWSAQASS
EINLGKFNQGDYFAAVEDKNHSENVSRVLYPDDSTYSGRELRLRQEYFLVSSTIQDILSR
HYQLHKTYDNLADKIAIHLNDTHPVLSIPEMMRLLIDEHQFSWDDAFEVCCQVFSYTNHT
LMSEALETWPVDMLGKILPRHLQIIFEINDYFLKTLQEQYPNDTDLLGRASIIDESNGRR
VRMAWLAVVVSHKVNGVSELHSNLMVQSLFADFAKIFPGRFTNVTNGVTPRRWLAVANPS
LSAVLDEHLGRNWRTDLSLLNELQQHCDFPMVNHAVHQAKLENKKRLAEYIAQQLNVVVN
PKALFDVQIKRIHEYKRQLMNVLHVITRYNRIKADPDAKWVPRVNIFGGKAASAYYMAKH
IIHLINDVAKVINNDPQIGDKLKVVFIPNYSVSLAQLIIPAADLSEQISLAGTEASGTSN
MKFALNGALTIGTLDGANVEMLDHVGADNIFIFGNTAEEVEELRRQGYKPREYYEKDEEL
HQVLTQIGSGVFSPEDPGRYRDLVDSLINFGDHYQVLADYRSYVDCQDKVDELYELQEEW
TAKAMLNIANMGYFSSDRTIKEYADHIWHIDPVRL |
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References |
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External Links: | |
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General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Choi, Y. L., Kawamukai, M., Utsumi, R., Sakai, H., Komano, T. (1989). "Molecular cloning and sequencing of the glycogen phosphorylase gene from Escherichia coli." FEBS Lett 243:193-198. Pubmed: 2645169
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Kumar, A., Larsen, C. E., Preiss, J. (1986). "Biosynthesis of bacterial glycogen. Primary structure of Escherichia coli ADP-glucose:alpha-1,4-glucan, 4-glucosyltransferase as deduced from the nucleotide sequence of the glgA gene." J Biol Chem 261:16256-16259. Pubmed: 3097003
- Romeo, T., Kumar, A., Preiss, J. (1988). "Analysis of the Escherichia coli glycogen gene cluster suggests that catabolic enzymes are encoded among the biosynthetic genes." Gene 70:363-376. Pubmed: 2975249
- Yu, F., Jen, Y., Takeuchi, E., Inouye, M., Nakayama, H., Tagaya, M., Fukui, T. (1988). "Alpha-glucan phosphorylase from Escherichia coli. Cloning of the gene, and purification and characterization of the protein." J Biol Chem 263:13706-13711. Pubmed: 3047129
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