Peptide transport system ATP-binding protein sapD (P0AAH4)

Identification
Name:Peptide transport system ATP-binding protein sapD
Synonyms:Not Available
Gene Name:sapD
Enzyme Class:Not Available
Biological Properties
General Function:Involved in nucleotide binding
Specific Function:Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides
Cellular Location:Cell inner membrane; Peripheral membrane protein (Potential)
SMPDB Pathways:Not Available
KEGG Pathways:
  • Cationic antimicrobial peptide (CAMP) resistance eco01503
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB21225Hydrogen ionMetaboCard
ECMDB04139PotassiumMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
peptide transporter activity
purine nucleoside binding
pyrophosphatase activity
substrate-specific transporter activity
transporter activity
Process
establishment of localization
peptide transport
transport
Gene Properties
Blattner:b1291
Gene OrientationCounterclockwise
Centisome Percentage:29.11
Left Sequence End1350660
Right Sequence End1351652
Gene Sequence:
>993 bp
ATGCCATTACTCGATATTCGTAACCTGACCATTGAATTTAAAACCGGTGATGAGTGGGTT
AAAGCCGTCGACCGGGTAAGTATGACCTTAACCGAAGGTGAAATCCGCGGTCTTGTTGGT
GAATCCGGTTCCGGCAAGAGTTTGATTGCGAAAGCGATTTGTGGGGTGAATAAAGATAAC
TGGCGTGTTACTGCTGACCGTATGCGTTTTGATGATATCGATTTGCTGCGTCTCTCCGCA
CGCGAACGGCGCAAACTGGTTGGCCATAACGTGTCGATGATTTTCCAGGAACCGCAGTCG
TGTCTTGACCCTTCAGAACGTGTGGGCCGCCAGTTGATGCAAAACATCCCAGCCTGGACC
TATAAAGGCCGTTGGTGGCAGCGTTTTGGCTGGCGCAAACGCCGTGCCATTGAACTGCTG
CACCGCGTGGGGATTAAAGATCACAAAGATGCGATGCGCAGTTTTCCCTATGAGTTGACC
GAAGGTGAATGTCAGAAAGTGATGATAGCCATTGCACTGGCGAATCAACCGCGTCTGCTG
ATTGCTGACGAACCGACCAACTCAATGGAGCCAACAACCCAGGCGCAAATCTTTCGCCTG
CTGACGCGTCTCAACCAAAACAGCAATACCACTATTTTGCTTATCAGCCATGACTTACAA
ATGCTTAGCCAATGGGCGGATAAAATTAACGTGCTTTACTGCGGTCAAACAGTGGAAACC
GCGCCGAGTAAGGAGTTGGTGACGATGCCACATCATCCTTATACCCAGGCGCTGATCCGC
GCGATACCAGACTTCGGCAGCGCGATGCCGCATAAAAGTCGCCTCAATACGCTGCCCGGC
GCTATCCCACTGCTGGAACAGTTACCGATTGGTTGTCGTCTGGGGCCACGTTGCCCGTAT
GCACAACGAGAATGCATTGTGACGCCACGTTTGACGGGGGCGAAAAATCATCTCTATGCC
TGTCATTTCCCGCTGAACATGGAGAAAGAGTGA
Protein Properties
Pfam Domain Function:
Protein Residues:330
Protein Molecular Weight:37660
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Peptide transport system ATP-binding protein sapD
MPLLDIRNLTIEFKTGDEWVKAVDRVSMTLTEGEIRGLVGESGSGKSLIAKAICGVNKDN
WRVTADRMRFDDIDLLRLSARERRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPAWT
YKGRWWQRFGWRKRRAIELLHRVGIKDHKDAMRSFPYELTEGECQKVMIAIALANQPRLL
IADEPTNSMEPTTQAQIFRLLTRLNQNSNTTILLISHDLQMLSQWADKINVLYCGQTVET
APSKELVTMPHHPYTQALIRAIPDFGSAMPHKSRLNTLPGAIPLLEQLPIGCRLGPRCPY
AQRECIVTPRLTGAKNHLYACHFPLNMEKE
References
External Links:
ResourceLink
Uniprot ID:P0AAH4
Uniprot Name:SAPD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1742104
Ecogene ID:EG12304
Ecocyc:EG12304
ColiBase:b1291
Kegg Gene:b1291
EchoBASE ID:EB2210
CCDB:SAPD_ECOLI
BacMap:16129252
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553