Aldose 1-epimerase (P0A9C3)

Identification
Name:Aldose 1-epimerase
Synonyms:
  • Galactose mutarotase
  • Type-1 mutarotase
Gene Name:galM
Enzyme Class:
Biological Properties
General Function:Involved in aldose 1-epimerase activity
Specific Function:Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose
Cellular Location:Cytoplasm (Probable)
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0alpha-D-Glucose ↔ 1.0b-D-Glucose
ReactionCard
1.0Thumb → 1.0Thumb
1.0alpha-D-Glucose → 1.0b-D-Glucose
ReactionCard
SMPDB Reactions:
1.0Thumb → 1.0Thumb
1.0Alpha-D-Galactose → 1.0beta-D-Galactose
ReactionCard
1.0Thumb → 1.0Thumb
1.0beta-D-Galactose → 1.0Alpha-D-Galactose
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Galactose ↔ 1.0D-Galactose
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0beta-D-Galactose → 1.0D-Galactose
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB04012Alpha-D-GalactoseMetaboCard
ECMDB03345alpha-D-GlucoseMetaboCard
ECMDB00516b-D-GlucoseMetaboCard
ECMDB04025beta-D-GalactoseMetaboCard
ECMDB00143D-GalactoseMetaboCard
GO Classification:
Function
aldose 1-epimerase activity
binding
carbohydrate binding
catalytic activity
isomerase activity
racemase and epimerase activity
racemase and epimerase activity, acting on carbohydrates and derivatives
Process
alcohol metabolic process
carbohydrate metabolic process
galactose metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
primary metabolic process
small molecule metabolic process
Gene Properties
Blattner:b0756
Gene OrientationCounterclockwise
Centisome Percentage:16.96
Left Sequence End787020
Right Sequence End788060
Gene Sequence:
>1041 bp
GTGCTGAACGAAACTCCCGCACTGGCACCCGATGGTCAGCCGTACCGACTGTTAACTTTG
CGTAACAACGCAGGGATGGTAGTCACGCTGATGGACTGGGGTGCGACTTTACTTTCCGCC
CGTATTCCGCTTTCCGATGGCAGCGTCCGCGAGGCGCTGCTCGGCTGTGCCAGCCCGGAA
TGCTATCAGGATCAGGCCGCGTTTCTGGGGGCCTCTATTGGTCGTTATGCCAACCGTATC
GCCAATAGCCGTTATACCTTTGACGGTGAAACCGTGACGCTTTCGCCAAGTCAGGGCGTT
AACCAGCTGCACGGCGGGCCGGAAGGGTTCGACAAACGTCGCTGGCAGATTGTGAACCAG
AACGATCGTCAGGTGCTGTTTGCCCTGAGTTCAGATGATGGTGATCAGGGCTTCCCGGGT
AATCTCGGCGCGACGGTGCAATATCGTCTGACCGACGATAACCGTATCTCCATTACTTAT
CGCGCCACAGTTGATAAACCTTGCCCGGTGAATATGACTAATCACGTCTATTTCAATCTT
GACGGCGAGCAGTCTGACGTGCGCAATCACAAGTTGCAGATTCTGGCGGACGAATATCTG
CCGGTTGATGAAGGCGGCATTCCGCACGACGGCCTGAAATCTGTCGCCGGAACGTCTTTT
GATTTCCGCAGCGCCAAAATCATCGCCAGTGAGTTTCTTGCCGACGACGATCAGCGCAAA
GTGAAAGGTTACGATCACGCATTCTTGTTACAGGCCAAAGGCGATGGCAAGAAAGTGGCG
GCGCATGTCTGGTCAGCAGATGAAAAATTGCAGCTGAAGGTCTACACCACCGCTCCGGCT
CTGCAATTCTACTCCGGCAACTTCCTCGGCGGCACACCGTCGCGGGGAACCGAACCTTAC
GCCGACTGGCAAGGGCTGGCTCTGGAAAGCGAGTTTCTACCGGACAGCCCGAACCACCCT
GAATGGCCGCAACCGGACTGCTTCCTGCGTCCTGGCGAAGAGTATTCCAGCCTGACGGAA
TATCAGTTTATTGCTGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:346
Protein Molecular Weight:38190
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Aldose 1-epimerase
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQ
NDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNL
DGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPY
ADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQFIAE
References
External Links:
ResourceLink
Uniprot ID:P0A9C3
Uniprot Name:GALM_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651341
Ecogene ID:EG11698
Ecocyc:EG11698
ColiBase:b0756
Kegg Gene:b0756
EchoBASE ID:EB1649
CCDB:GALM_ECOLI
BacMap:16128724
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Bouffard, G. G., Rudd, K. E., Adhya, S. L. (1994). "Dependence of lactose metabolism upon mutarotase encoded in the gal operon in Escherichia coli." J Mol Biol 244:269-278. Pubmed: 7966338
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232