| Identification |
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| Name: | Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase |
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| Synonyms: | - Apo-ACP nucleodityltransferase
- Holo-ACP synthase
- Holo-citrate lyase synthase
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| Gene Name: | citX |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Involved in prosthetic group biosynthetic process |
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| Specific Function: | Transfers 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | |
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| KEGG Pathways: | |
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| KEGG Reactions: | | | |
1.0 | ↔ | 1.0 |
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| SMPDB Reactions: | |
1.0 | + | 1.0 [an apo citrate-lyase acyl-carrier protein] | → | 1.0Pyrophosphate | + | 1.0 | + | 1.0[a holo citrate lyase acyl-carrier protein] |
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| EcoCyc Reactions: | |
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| Complex Reactions: | |
1.0 | + | 1.0citrate lyase apo-[acyl-carrier-protein] | → | 1.0citrate lyase holo-[acyl-carrier-protein] | + | 1.0 |
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| Metabolites: | |
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| GO Classification: | | Process |
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| biosynthetic process | | cellular biosynthetic process | | cofactor biosynthetic process | | metabolic process | | prosthetic group biosynthetic process |
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| Gene Properties |
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| Blattner: | b0614 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 13.94 |
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| Left Sequence End | 646707 |
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| Right Sequence End | 647258 |
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| Gene Sequence: | >552 bp
ATGTTGTTAGAACAGGGGTGGCTGGTTGGCGCGCGCCGCGTTCCCTCACCACATTACGAT
TGCCGCCCGGATGACGAAACACCCACCCTGCTGGTGGTGCACAATATTAGCCTGCCGCCA
GGCGAGTTTGGCGGTCCGTGGATCGACGCATTATTCACTGGAACTATTGATCCGCAGGCA
CATCCTTTCTTTGCTGAGATCGCCCATTTGCGCGTCTCCGCTCACTGTTTGATTCGCCGT
GATGGTGAAATAGTCCAGTATGTTCCTTTCGATAAACGTGCATGGCATGCGGGAGTCTCT
CAGTATCAGGGGCGCGAACGCTGCAATGATTTTTCTATTGGGATTGAGCTTGAAGGCACC
GATACGCTGGCGTATACCGATGCGCAGTATCAACAGCTTGCGGCGGTTACGCGGGCACTG
ATTGATTGCTATCCGGATATCGCTAAAAACATGACGGGCCATTGTGATATTGCGCCGGAT
CGGAAAACCGATCCCGGTCCTGCATTTGATTGGGCACGGTTTCGTGTGCTGGTCAGCAAG
GAGACAACATGA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 183 |
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| Protein Molecular Weight: | 20270 |
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| Protein Theoretical pI: | 7 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
MHLLPELASHHAVSIPELLVSRDERQARQHVWLKRHPVPLVSFTVVAPGPIKDSEVTRRI
FNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHSHPLGRL
WDIDVLTPEGEILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLNDVDAC
NVN |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Pos, K. M., Dimroth, P., Bott, M. (1998). "The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts." J Bacteriol 180:4160-4165. Pubmed: 9696764
- Schneider, K., Dimroth, P., Bott, M. (2000). "Biosynthesis of the prosthetic group of citrate lyase." Biochemistry 39:9438-9450. Pubmed: 10924139
- Schneider, K., Dimroth, P., Bott, M. (2000). "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group." FEBS Lett 483:165-168. Pubmed: 11042274
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