Alanine racemase, biosynthetic (P0A6B4)

Identification
Name:Alanine racemase, biosynthetic
Synonyms:Not Available
Gene Name:alr
Enzyme Class:
Biological Properties
General Function:Involved in alanine racemase activity
Specific Function:Provides the D-alanine required for cell wall biosynthesis
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0L-Alanine ↔ 1.0D-Alanine
ReactionCard
SMPDB Reactions:
1.0L-Alanine+1.0Thumb ↔ 1.0Thumb
1.0L-Alanine + 1.0L-Alanine ↔ 1.0D-Alanine
ReactionCard
1.0L-Alanine+1.0Thumb → 1.0Thumb
1.0L-Alanine + 1.0L-Alanine → 1.0D-Alanine
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0L-Alanine ↔ 1.0D-Alanine
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0L-Alanine → 1.0D-Alanine
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01310D-AlanineMetaboCard
ECMDB00161L-AlanineMetaboCard
GO Classification:
Function
alanine racemase activity
amino-acid racemase activity
catalytic activity
isomerase activity
racemase and epimerase activity
racemase and epimerase activity, acting on amino acids and derivatives
Process
alanine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
pyruvate family amino acid metabolic process
Gene Properties
Blattner:b4053
Gene OrientationClockwise
Centisome Percentage:91.90
Left Sequence End4263805
Right Sequence End4264884
Gene Sequence:
>1080 bp
ATGAAAAAATATCTCGCGCTGGCTTTGATTGCGCCGTTGCTCATCTCCTGTTCGACGACC
AAAAAAGGCGATACCTATAACGAAGCCTGGGTCAAAGATACCAACGGTTTTGATATTCTG
ATGGGGCAATTTGCCCACAATATTGAGAACATCTGGGGCTTCAAAGAGGTGGTGATCGCT
GGTCCTAAGGACTACGTGAAATACACCGATCAATATCAGACCCGCAGCCACATCAACTTC
GATGACGGTACGATTACTATCGAAACCATCGCCGGGACAGAACCTGCCGCGCATTTGCGC
CGGGCAATTATCAAAACGTTATTGATGGGTGACGATCCGAGTTCGGTCGATCTCTATTCC
GACGTTGATGATATTACGATTTCGAAAGAACCTTTCCTTTACGGTCAGGTGGTGGACAAC
ACCGGGCAGCCGATTCGCTGGGAAGGTCGCGCAAGCAACTTCGCGGATTATCTGCTGAAA
AACCGTCTGAAGAGCCGCAGCAACGGGCTGCGTATCATCTACAGCGTCACCATTAACATG
GTGCCGAACCACCTTGATAAACGTGCGCACAAATATCTCGGCATGGTCCGCCAGGCGTCA
CGGAAATATGGCGTTGATGAGTCGCTGATTCTGGCAATTATGCAGACCGAATCTTCCTTT
AACCCGTATGCGGTCAGCCGTTCCGATGCGCTGGGATTAATGCAGGTGGTACAACATACT
GCCGGGAAAGATGTGTTCCGCTCGCAGGGGAAATCCGGCACGCCGAGCCGCAGTTTCTTG
TTTGATCCTGCCAGCAATATTGATACCGGCACCGCGTATCTGGCGATGCTGAACAATGTT
TATCTCGGCGGAATTGATAACCCAACATCGCGGCGTTATGCCGTCATCACCGCCTATAAC
GGCGGCGCAGGCAGCGTGCTGCGAGTCTTTTCGAATGATAAGATTCAGGCTGCCAATATT
ATTAACACCATGACGCCGGGCGATGTTTATCAGACGCTGACGACCCGCCATCCCTCTGCG
GAATCTCGCCGTTATCTTTATAAAGTGAATACCGCGCAAAAATCCTACCGCCGCCGATAA
Protein Properties
Pfam Domain Function:
Protein Residues:359
Protein Molecular Weight:39153
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Alanine racemase, biosynthetic
MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARL
EEALRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVW
MKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNT
FCEGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSS
LIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGR
VAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD
References
External Links:
ResourceLink
Uniprot ID:P0A6B4
Uniprot Name:ALR1_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675773
Ecogene ID:EG10001
Ecocyc:EG10001
ColiBase:b4053
Kegg Gene:b4053
EchoBASE ID:EB0001
CCDB:ALR1_ECOLI
BacMap:16131879
General Reference:
  • Blattner, F. R., Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L. (1993). "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes." Nucleic Acids Res 21:5408-5417. Pubmed: 8265357
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kuramitsu, S., Inoue, K., Ogawa, T., Ogawa, H., Kagamiyama, H. (1985). "Aromatic amino acid aminotransferase of Escherichia coli: nucleotide sequence of the tyrB gene." Biochem Biophys Res Commun 133:134-139. Pubmed: 3907634
  • Lilley, P. E., Stamford, N. P., Vasudevan, S. G., Dixon, N. E. (1993). "The 92-min region of the Escherichia coli chromosome: location and cloning of the ubiA and alr genes." Gene 129:9-16. Pubmed: 8335265
  • Nakayama, N., Arai, N., Bond, M. W., Kaziro, Y., Arai, K. (1984). "Nucleotide sequence of dnaB and the primary structure of the dnaB protein from Escherichia coli." J Biol Chem 259:97-101. Pubmed: 6323420