Lithium (ECMDB21393) (M2MDB001788)

IdentificationTaxonomyPhysical PropertiesBiological PropertiesSpectraConcentrationsLinksReferencesTransporters (2)XML
Proteins (2)
Record Information
Version2.0
Creation Date2012-07-30 14:55:42 -0600
Update Date2015-09-13 12:56:15 -0600
Secondary Accession Numbers
  • ECMDB21393
Identification
Name:Lithium
DescriptionLithium (Li) is an alkali metal with atomic number 3. Trace amounts of lithium are present in all organisms, though the element serves no apparent vital biological function. (Wikipedia) Scientific research has suggested that lithium is an inhibitor of several E. coli enzymes, such as L-rhamnulose-1-phosphate aldolase. (EcoCyc)
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms:
  • Li
  • Li(+)
  • Li(+) cation
  • Li(+) ion
  • Lithium atom
  • Lithium cation
  • Lithium element
  • LITHIUM ION
  • Lithium(+)
  • Lithium, ion
  • Lithium, ion (Li1+)
Chemical Formula:Li
Weight:Average: 6.941
Monoisotopic: 7.016004049
InChI Key:HBBGRARXTFLTSG-UHFFFAOYSA-N
InChI:InChI=1S/Li/q+1
CAS number:7439-93-2
IUPAC Name:lithium(1+) ion
Traditional IUPAC Name:lithium(1+) ion
SMILES:[Li+]
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkali metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:1
Melting point:190 °C
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
SMPDB Pathways:
Galactose metabolismPW000821 ThumbThumb?image type=greyscaleThumb?image type=simple
inner membrane transportPW000786 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways:
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-9000000000-d37172edddcf6ff27879View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-9000000000-d37172edddcf6ff27879View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9000000000-d37172edddcf6ff27879View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-9000000000-00619c7d65eb4b7f8f3dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0a4i-9000000000-00619c7d65eb4b7f8f3dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9000000000-00619c7d65eb4b7f8f3dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-9000000000-29e69b4fc922829a038dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-9000000000-29e69b4fc922829a038dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9000000000-29e69b4fc922829a038dView in MoNA
References
References:
  • Aghdam SY, Barger SW: Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium. Curr Alzheimer Res. 2007 Feb;4(1):21-31. Pubmed: 17316163
  • Kofman O, Belmaker RH: Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatry. 1993 Dec 15;34(12):839-52. Pubmed: 8110911
  • Quiroz JA, Machado-Vieira R, Zarate CA Jr, Manji HK: Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology. 2010;62(1):50-60. doi: 10.1159/000314310. Epub 2010 May 7. Pubmed: 20453535
  • Waring WS: Management of lithium toxicity. Toxicol Rev. 2006;25(4):221-30. Pubmed: 17288494
  • Zhong J, Lee WH: Lithium: a novel treatment for Alzheimer's disease? Expert Opin Drug Saf. 2007 Jul;6(4):375-83. Pubmed: 17688381
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Download (PDF)
External Links:
ResourceLink
CHEBI ID30145
HMDB IDHMDB05949
Pubchem Compound ID28486
Kegg IDC15473
ChemSpider ID26502
WikipediaLithium
BioCyc IDLI%2b
EcoCyc IDLI%2b
Ligand ExpoLI

Transporters

Protein Details
1. Melibiose carrier protein
General function:
Involved in transporter activity
Specific function:
Responsible for melibiose transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system)
Gene Name:
melB
Uniprot ID:
P02921
Molecular weight:
52217
Protein Details
2. Sodium/proline symporter
General function:
Involved in proline:sodium symporter activity
Specific function:
Catalyzes the sodium-dependent uptake of extracellular L-proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of propionate
Gene Name:
putP
Uniprot ID:
P07117
Molecular weight:
54344