Multidrug resistance protein mdtA (Q8X7J5)

Identification
Name:Multidrug resistance protein mdtA
Synonyms:
  • Multidrug transporter mdtA
Gene Name:mdtA
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transmembrane transport
Specific Function:The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate
Cellular Location:Cell inner membrane; Peripheral membrane protein (Potential)
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Component
cell part
membrane
Function
protein transporter activity
substrate-specific transporter activity
transporter activity
Process
establishment of localization
protein secretion
protein transport
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1248 bp
ATGACTGATCAAGCTGAAAAAAAGCACTCTGCATTTTGGGGTGTTATGGTTATAGCAGGT
ACAGTAATCGGTGGAGGTATGTTTGCTTTACCTGTGGATCTTGCCGGTGCCTGGTTTTTC
TGGGGTGCCTTTATCCTTATCATTGCCTGGTTTTCAATGCTTCATTCCGGGTTATTGTTA
TTAGAAGCAAATTTAAATTATCCCGTCGGCTCCAGTTTTAACACCATCACCAAAGATTTA
ATCGGTAACACCTGGAACATTATCAGCGGTATTACCGTTGCCTTCGTTCTCTATATCCTC
ACTTATGCCTATATCTCTGCTAATGGTGCGATCATTAGTGAAACGATATCAATGAATTTG
GGTTATCACGCTAATCCACGTATTGTCGGGATCTGCACAGCCATTTTCGTTGCCAGCGTA
TTGTGGATAAGCTCGTTAGCCGCCAGTCGTATTACCTCATTGTTCCTCGGGCTGAAGATT
ATCTCCTTTGTGATCGTGTTTGGTTCTTTCTTCTTCCTGGTCGATTACTCCATTCTGCGC
GATGCCACCAGCTCCACTGCGGGAACGTCTTACTTCCCGTATATCTTTATGGCTTTGCCG
GTGTGTCTGGCGTCATTTGGTTTCCACGGCAATATTCCCAGCCTGATTATTTGCTATGGC
AAACGCAAAGATAAGCTAATCAAAAGCGTGGTCTTCGGTTCGCTGCTGGCGCTGGTGATT
TATCTCTTCTGGCTCTATTGCACCATGGGGAATATTCCGCGAGAAAGCTTTAAGGCGATT
ATTTCCTCAGGCGGCAACGTTGATTCACTGGTGAAATCGTTCCTCGGCACCAAACAGCAC
GGCATTATCGAGTTTTGCCTGCTGGTGTTCTCCAACTTAGCTGTCGCCAGCTCGTTTTTT
GGTGTCACGCTGGGATTGTTCGATTATCTGGCGGACCTGTTTAAGATTGATAACTCCCAC
GGCGGGCGTTTCAAAACCGTGCTGTTAACCTTCCTGCCACCCGCGTTGTTGTATCTGATC
TTCCCGAACGGCTTTATTTACGGGATCGGCGGTGCCGGACTGTGCGCCACTATTTGGGCG
GTCATTATTCCCGCAGTGCTGGCAATCAAAGCTCGCAAAAAGTTTCCCAATCAGATGTTC
ACGGTCTGGGGCGGCAATCTTATTCCGGCGATTGTCATTCTCTTTGGTATAACCGTAATT
TTGTGCTGGTTCGGCAACGTCTTTAACGTGTTACCTAAATTTGGCTAA
Protein Properties
Pfam Domain Function:
Protein Residues:415
Protein Molecular Weight:44498
Protein Theoretical pI:9
Signaling Regions:
  • 1-21
Transmembrane Regions:
  • None
Protein Sequence:
>Multidrug resistance protein mdtA
MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSQSAAPGATKQAQQSPAGGRRGMRSGPLA
PVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDP
SQFKVALAQAQGQLAKDKATLTNARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIK
ADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLLFTL
PESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQD
DALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQ
KVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS
References
External Links:
ResourceLink
Uniprot ID:Q8X7J5
Uniprot Name:MDTA_ECO57
GenBank Gene ID:AE005174
Genebank Protein ID:12518554
EchoBASE ID:EB3809
CCDB:MDTA_ECO57
General Reference:
  • Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H. (2001). "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." DNA Res 8:11-22. Pubmed: 11258796
  • Perna, N. T., Plunkett, G. 3rd, Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., Posfai, G., Hackett, J., Klink, S., Boutin, A., Shao, Y., Miller, L., Grotbeck, E. J., Davis, N. W., Lim, A., Dimalanta, E. T., Potamousis, K. D., Apodaca, J., Anantharaman, T. S., Lin, J., Yen, G., Schwartz, D. C., Welch, R. A., Blattner, F. R. (2001). "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Nature 409:529-533. Pubmed: 11206551