Multidrug resistance protein mdtB (Q8X7J4)

Identification
Name:Multidrug resistance protein mdtB
Synonyms:
  • Multidrug transporter mdtB
Gene Name:mdtB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate
Cellular Location:Cell inner membrane; Multi-pass membrane protein (Potential)
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>3123 bp
ATGCAAGTGTTACCCCCGAGCAGCACAGGCGGCCCGTCGCGCCTGTTTATTATGCGTCCT
GTGGCCACCACGCTGCTGATGGTGGCGATCTTACTCGCCGGGATTATCGGTTATCGCGCC
CTGCCCGTTTCGGCGCTGCCGGAAGTGGACTATCCGACCATTCAGGTGGTCACGCTCTAC
CCAGGTGCGAGCCCGGATGTCATGACCTCTGCCGTTACCGCGCCGCTCGAACGCCAGTTC
GGGCAGATGTCTGGCCTGAAACAGATGTCGTCGCAAAGTTCCGGCGGTGCGTCAGTTATC
ACTTTACAGTTCCAGCTAACATTACCGCTGGATGTCGCCGAGCAGGAAGTGCAGGCCGCG
ATTAACGCTGCGACCAACTTGTTGCCGAGCGATCTGCCTAACCCGCCGGTTTACAGCAAA
GTGAACCCGGCAGATCCGCCGATCATGACGCTCGCCGTCACCTCAACAGCCATGCCGATG
ACGCAAGTGGAAGATATGGTGGAAACCCGCGTCGCGCAGAAAATCTCGCAGATTTCCGGC
GTCGGCCTGGTGACGCTTTCCGGCGGCCAGCGTCCGGCTGTTCGCGTCAAACTTAACGCT
CAGGCGATTGCCGCCCTCGGCCTGACCAGCGAAACCGTGCGCACCGCCATTACCGGCGCT
AACGTTAACTCGGCTAAAGGTAGCCTTGACGGCCCTTCCCGTGCGGTTACGCTTTCCGCT
AACGACCAGATGCAATCCGCCGAAGAGTATCGCCAGCTAATCATCGCCTACCAGAACGGC
GCGCCGATTCGTCTGGGCGATGTCGCAACTGTAGAGCAAGGTGCAGAAAACAGCTGGCTC
GGCGCATGGGCGAATAAAGAACAGGCCATTGTGATGAATGTTCAGCGCCAGCCCGGTGCT
AACATTATCTCCACCGCCGACAGCATCCGGCAGATGCTGCCACAGCTCACCGAGAGTCTG
CCGAAATCGGTGAAGGTGACGGTACTTTCTGACCGTACCACCAATATCCGCGCATCCGTC
GATGATACTCAGTTTGAATTGATGATGGCTATCGCGCTGGTAGTCATGATTATCTACCTG
TTTTTGCGCAATATTCCGGCGACCATCATTCCCGGCGTTGCAGTGCCGCTGTCGTTAATC
GGCACCTTCGCGGTCATGGTGTTTCTCGATTTTTCAATCAATAACCTGACGCTGATGGCG
TTAACTATCGCCACCGGGTTCGTGGTCGATGACGCCATCGTGGTGATCGAAAATATTTCC
CGCTATATCGAAAAAGGCGAAAAACCGTTGGCGGCGGCGCTCAAAGGCGCAGGTGAAATC
GGCTTTACCATTATCTCGCTGACCTTCTCGCTGATTGCGGTGTTGATCCCACTGCTGTTT
ATGGGCGATATCGTCGGGCGACTGTTCCGCGAATTTGCTATTACCCTGGCGGTAGCGATT
TTAATCTCAGCCGTGGTGTCGCTAACCCTGACACCGATGATGTGCGCACGGATGCTCAGC
CAGGAGTCGTTGCGTAAACAGAACCGCTTCTCCCGTGCCTCGGAAAAAATGTTCGACAGG
ATAATCGCCGCCTATGGTCGTGGACTGGCGAAAGTGCTGAATCATCCGTGGCTGACCTTA
AGCGTGGCGCTCAGCACGCTGCTGCTTAGCGTTCTATTGTGGGTGTTCATTCCGAAAGGT
TTCTTCCCGGTACAGGATAACGGCATTATTCAGGGCACTTTGCAGGCACCGCAATCCAGC
TCCTTTGCCAATATGGCCCAGCGGCAACGCCAGGTCGCGGACGTGATTTTGCAGGATCCG
GCAGTGCAAAGTCTGACCTCATTTGTTGGCGTTGATGGCACTAACCCGTCGCTGAACAGT
GCGCGTTTGCAGATCAACCTCAAACCGTTGGATGAACGTGATGATCGGGTGCAAAAAGTC
ATCGCCCGTCTGCAAACGGCGGTGGATAAAGTGCCGGGCGTCGATCTCTTCCTGCAACCA
ACGCAGGACCTGACCATCGATACTCAGGTCAGCCGCACCCAGTACCAGTTTACCTTGCAG
GCCACGTCACTGGATGCGCTCAGTACCTGGGTGCCACAGTTGATGGAAAAACTCCAGCAG
CTGCCACAGATTTCTGATGTCTCCAGCGACTGGCAGGACAAAGGGCTGGTGGCGTATGTC
AATGTTGATCGCGACAGCGCCAGCCGTCTGGGGATCAGCATGGCGGATGTCGATAACGCC
CTGTACAACGCGTTTGGTCAGCGACTGATTTCCACTATTTATACTCAGGCTAACCAGTAT
CGTGTAGTGCTGGAGCACAATACCGAAAATACCCCAGGCCTCGCGGCGCTGGATACCATT
CGCCTGACCAGCAGCGACGGCGGCGTGGTGCCGCTAAGCTCAATTGCCAAAATTGAGCAG
CGTTTTGCGCCGCTTTCCATCAACCATCTGGATCAGTTCCCGGTAACGACCATCTCCTTT
AACGTGCCGGATAACTATTCGCTGGGCGATGCGGTGCAGGCAATTATGGACACCGAGAAG
ACGCTGAATCTGCCGGTGGATATCACCACGCAATTCCAGGGCAGCACCCTCGCCTTCCAG
TCGGCGCTGGGCAGCACTGTCTGGCTGATTGTCGCGGCGGTGGTGGCGATGTATATCGTG
CTCGGCATTCTGTACGAGAGCTTTATTCACCCGATCACCATTCTCTCGACGCTACCCACG
GCAGGTGTTGGCGCCCTGCTGGCGTTAATGATTGCCGGTAGCGAACTGGATGTGATTGCG
ATTATCGGCATTATTTTGCTGATCGGTATCGTGAAGAAGAACGCCATCATGATGATCGAC
TTCGCGCTGGCTGCTGAGCGCGAGCAAGGCATGTCGCCGCGCGATGCAATCTACCAGGCT
TGTCTGTTGCGTTTTCGTCCGATCCTGATGACCACCCTGGCGGCTCTGCTTGGCGCGCTG
CCGCTGATGTTGAGTACCGGGGTCGGCGCGGAACTACGTCGTCCGTTAGGTATCGGCATG
GTCGGCGGCCTGATTGTCAGCCAGGTGCTGACGCTGTTCACCACGCCGGTGATTTATCTG
CTGTTTGACCGCCTGGCATTGTGGACCAAAAGTCGCTTTGCTCGCCATGAAGAGGAGGCG
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:1040
Protein Molecular Weight:112080
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • 15-37
  • 345-362
  • 367-389
  • 396-418
  • 438-460
  • 472-494
  • 535-557
  • 867-889
  • 909-931
  • 968-990
  • 1000-1022
Protein Sequence:
>Multidrug resistance protein mdtB
MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLY
PGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAA
INAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISG
VGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSA
NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGA
NIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYL
FLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENIS
RYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAI
LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTL
SVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDP
AVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQP
TQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQISDVSSDWQDKGLVAYV
NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTI
RLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEK
TLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPT
AGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA
CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYL
LFDRLALWTKSRFARHEEEA
References
External Links:
ResourceLink
Uniprot ID:Q8X7J4
Uniprot Name:MDTB_ECO57
GenBank Gene ID:AE005174
Genebank Protein ID:12516281
EchoBASE ID:EB3810
CCDB:MDTB_ECO57
General Reference:
  • Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H. (2001). "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." DNA Res 8:11-22. Pubmed: 11258796
  • Perna, N. T., Plunkett, G. 3rd, Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., Posfai, G., Hackett, J., Klink, S., Boutin, A., Shao, Y., Miller, L., Grotbeck, E. J., Davis, N. W., Lim, A., Dimalanta, E. T., Potamousis, K. D., Apodaca, J., Anantharaman, T. S., Lin, J., Yen, G., Schwartz, D. C., Welch, R. A., Blattner, F. R. (2001). "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Nature 409:529-533. Pubmed: 11206551