Multidrug resistance protein mdtC (Q7ACM1)

Identification
Name:Multidrug resistance protein mdtC
Synonyms:
  • Multidrug transporter mdtC
Gene Name:mdtC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>3078 bp
GTGAAGTTTTTTGCCCTCTTCATTTACCGCCCGGTGGCGACGATTTTACTGTCGGTCGCC
ATTACCCTGTGCGGCATACTGGGTTTCCGTATGCTGCCGGTCGCCCCGCTGCCGCAGGTC
GATTTTCCGGTGATTATGGTCAGCGCCTCGCTGCCCGGTGCGTCGCCGGAGACAATGGCG
TCTTCCGTTGCCACGCCGCTGGAGCGCTCACTTGGGCGCATTGCCGGGGTCAGTGAAATG
ACCTCCAGCAGTTCGCTCGGCAGCACGCGTATTATTTTGCAGTTTGATTTTGMCCGGGAT
ATCAACSGTGCGGCGCGTGATGTGCANGCGGCGATCAACGCCGCACAAAGTCTGCTGCCC
AGTGGGATGCCCAGCCGCCCGACTTATCGCAAAGCGAACCCGTCGGATGCGCCAATTATG
ATCCTCACGCTAACCTCCGATACTTATTCGCAGGGTGAACTGTACGATTTCGCCTCGACG
CAGCTGGCTCCGACGATTTCGCAAATCGACGGTGTCGGTGATGTCGATGTCGGCGGCAGC
TCGCTGCCCGCCGTGCGCGTCGGGCTGAACCCGCAGGCGCTGTTTAATCAGGGCGTGTCG
CTGGACGACGTACGCACTGCCATCAGCAATGCCAACGTGCGTAAACCGCAGGGGGCGCTG
GAAGATGGCACTCACCGCTGGCAGATCCAGACCAACGATGAACTGAAAACCGCCGCTGAA
TATCAGCCGCTGATTATTCACTACAACAACGGCGGCGCGGTTCGTCTGGGCGATGTGGCG
ACGGTGACCGACTCAGTGCAGGATGTGCGCAACGCCGGGATGACCAACGCCAAACCGGCT
ATTTTACTGATGATCCGCAAATTGCCGGAAGCCAATATTATCCAGACGGTAGACAGCATC
CGGGCAAAATTACCGGAGTTGCAGGAAACCATTCCGGCGGCGATTGATCTGCAAATTGCC
CAGGATCGCTCCCCCACCATTCGCGCCTCGCTGGAAGAAGTCGAGCAAACGCTGATTATC
TCGGTGGCGCTGGTGATTCTGGTGGTCTTTTTATTCCTGCGCTCGGGTCGCGCCACTATT
ATTCCCGCCGTTGCGGTGCCGGTTTCGCTGATTGGTACGTTTGCGGCGATGTACCTGTGC
GGATTCAGTCTCAATAACCTTTCGTTAATGGCGCTCACCATCGCTACTGGTTTCGTGGTG
GATGACGCCATCGTGGTGCTGGAAAACATTGCACGTCATCTGGAAGCGGGAATGAAACCG
TTGCAAGCCGCACTGCAAGGTACTCGCGAAGTCGGTTTTACGGTGCTGTCGATGAGTCTG
TCGCTGGTGGCGGTGTTCCTGCCGCTGCTGTTGATGGGCGGATTGCCGGGCCGACTGTTA
CGCGAGTTTGCCGTGACGCTTTCTGTCGCCATTGGTATTTCGTTGCTGGTTTCTCTGACA
TTAACGCCAATGATGTGTGGCTGGATGCTGAAAGCCAGCAAGCCGCGCGAGCAAAAGCGA
CTGCGTGGTTTTGGTCGCATGTTGGTAGCCCTGCAACAAGGCTATGGTAAGTCACTGAAA
TGGGTGCTCAATCATACCCGTCTGGTGGGCATGGTGCTGCTTGGCACCATTGCTTTGAAT
ATCTGGCTATATATCTCGATTCCGAAAACCTTCTTCCCGGAGCAGGACACTGGCGTGTTG
ATGGGCGGGATACAGGCGGATCAGAGTATTTCGTTTCAGGCGATGCGCGGTAAGTTGCAG
GATTTCATGAAAATTATCCGTGACGATCCGGCAGTGGATAATGTCACCGGCTTTACCGGC
GGTTCGCGAGTGAACAGCGGGATGATGTTTATCACCCTCAAGCCACGCGACGAACGCAGC
GAAACAGCGCAGCAAATTATTGACCGTCTACGCGTGAAGCTGGCGAAAGAACCGGGGGCG
AATCTGTTCCTGATGGCGGTACAGGATATTCGCGTTGGCGGACGTCAGTCGAACGCCAGC
TACCAGTACACGTTGTTATCCGACGACCTGGCGGCACTGCGCGAATGGGAGCCGAAAATC
CGCAAAAAACTGGCGACATTGCCGGAACTGGCGGACGTGAACTCCGATCAGCAGGATAAC
GGCGCGGAGATGAATCTGGTTTACGATCGCGACACCATGGCACGGCTGGGAATCGACGTA
CAGGCCGCCAACAGCCTGTTAAATAACGCCTTCGGTCAGCGGCAAATCTCGACCATTTAC
CAGCCGATGAACCAGTATAAAGTGGTGATGGAAGTGGATCCGCGCTATACCCAGGACATC
AGCGCGCTGGAAAAAATGTTCGTAATCAATAACGAAGGAAAAGCGATCCCGCTGTCGTAT
TTCGCTAAATGGCAACCGGCGAATGCCCCACTATCGGTGAATCATCAGGGATTATCGGCA
GCCTCGACCATCTCGTTCAACCTGCCGACCGGAAAATCGCTCTCGGACGCCAGTGCGGCG
ATCGATCGCGCAATGACCCAGCTTGGTGTGCCTTCGACGGTGCGCGGCAGTTTTGCCGGC
ACGGCGCAGGTGTTCCAGGAGACGATGAACTCACAGGTGATCCTGATTATCGCCGCCATC
GCCACGGTGTATATCGTGCTGGGTATCCTTTACGAGAGTTACGTACATCCGCTGACGATT
CTCTCCACCCTGCCCTCGGCGGGCGTTGGAGCGCTGCTGGCGCTGGAGCTGTTCAATGCC
CCGTTCAGCCTAATCGCCCTGATAGGGATCATGCTATTAATCGGCATTGTGAAGAAAAAC
GCCATTATGATGGTCGATTTTGCGCTTGAAGCCCAACGGCACGGTAACCTGACGCCGCAG
GAAGCTATTTTCCAGGCCTGTCTGCTGCGTTTTCGCCCGATTATGATGACTACCCTGGCG
GCGCTGTTTGGCGCGCTGCCGCTGGTGTTGTCGGGCGGTGACGGCTCGGAGCTGCGGCAA
CCCTTGGGGATCACCATTGTCGGCGGTCTGGTGATGAGTCAGCTCCTGACGCTGTATACC
ACGCCGGTGGTATATCTCTTTTTCGACCGTCTGCGGCTGCGTTTTTCGCGTAAATCTAAA
CAAACGGTAACCGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:1025
Protein Molecular Weight:111047
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • 7-29
  • 336-353
  • 360-379
  • 389-411
  • 431-453
  • 468-490
  • 853-875
  • 895-917
  • 948-970
  • 985-1007
Protein Sequence:
>Multidrug resistance protein mdtC
MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMA
SSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLP
SGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGS
SLPAVRVGLNPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAE
YQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSI
RAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATI
IPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKP
LQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLT
LTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGMVLLGTIALN
IWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG
GSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNAS
YQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDV
QAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSY
FAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAG
TAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNA
PFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLA
ALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKSK
QTVTE
References
External Links:
ResourceLink
Uniprot ID:Q7ACM1
Uniprot Name:MDTC_ECO57
GenBank Gene ID:AE005174
Genebank Protein ID:12516282
EchoBASE ID:EB3811
CCDB:MDTC_ECO57
General Reference:
  • Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H. (2001). "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." DNA Res 8:11-22. Pubmed: 11258796
  • Perna, N. T., Plunkett, G. 3rd, Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., Posfai, G., Hackett, J., Klink, S., Boutin, A., Shao, Y., Miller, L., Grotbeck, E. J., Davis, N. W., Lim, A., Dimalanta, E. T., Potamousis, K. D., Apodaca, J., Anantharaman, T. S., Lin, J., Yen, G., Schwartz, D. C., Welch, R. A., Blattner, F. R. (2001). "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Nature 409:529-533. Pubmed: 11206551