4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (Q46938)

Identification
Name:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
Synonyms:
  • 5-keto-4-deoxyuronate isomerase
  • DKI isomerase
Gene Name:kduI
Enzyme Class:
Biological Properties
General Function:Involved in 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
Specific Function:4-deoxy-L-threo-5-hexosulose uronate = 3- deoxy-D-glycero-2,5-hexodiulosonate
Cellular Location:Not Available
SMPDB Pathways:
  • Collection of Reactions without pathways PW001891
KEGG Pathways:
  • Pentose and glucuronate interconversions ec00040
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.05-Dehydro-4-deoxy-D-glucuronate ↔ 1.0(4S)-4,6-Dihydroxy-2,5-dioxohexanoate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.05-Dehydro-4-deoxy-D-glucuronate → 1.0(4S)-4,6-Dihydroxy-2,5-dioxohexanoate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB20011(4S)-4,6-Dihydroxy-2,5-dioxohexanoateMetaboCard
ECMDB201035-Dehydro-4-deoxy-D-glucuronateMetaboCard
GO Classification:
Function
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
catalytic activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
isomerase activity
Process
carbohydrate metabolic process
cellular polysaccharide catabolic process
metabolic process
pectin catabolic process
polysaccharide catabolic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Blattner:b2843
Gene OrientationCounterclockwise
Centisome Percentage:64.26
Left Sequence End2981310
Right Sequence End2982146
Gene Sequence:
>837 bp
ATGGAAATGCTCGAAGAGCACCGCTGTTTTGAAGGCTGGCAGCAACGCTGGCGACACGAC
TCCAGTACCTTAAACTGCCCGATGACGTTCAGTATCTTTCTCCCTCCACCTCGTGATCAC
ACTCCGCCACCAGTGCTGTACTGGCTTTCCGGATTAACCTGCAATGACGAGAACTTCACC
ACCAAGGCGGGTGCCCAGCGGGTAGCGGCGGAACTGGGGATTGTACTGGTGATGCCAGAC
ACCAGCCCGCGCGGCGAAAAGGTTGCCAACGACGATGGCTACGATTTAGGCCAGGGCGCA
GGCTTTTATCTTAATGCCACGCAACCGCCGTGGGCGACGCATTACCGGATGTATGATTAT
CTGCGCGATGAATTACCGGCGCTGGTTCAGTCGCAATTTAATGTCAGCGACCGCTGCGCC
ATTAGCGGTCACTCAATGGGTGGTCACGGTGCGCTGATTATGGCGCTGAAAAATCCGGGT
AAATACACCAGCGTTTCGGCCTTTGCGCCAATTGTGAATCCGTGCAGCGTCCCGTGGGGA
ATCAAAGCGTTTAGCAGCTATTTAGGTGAGGACAAAAATGCATGGCTGGAATGGGACAGT
TGCGCACTGATGTATGCCAGTAACGCGCAGGATGCGATCCCGACGCTTATCGATCAGGGC
GATAATGATCAGTTTCTTGCCGACCAGTTGCAACCTGCGGTACTGGCAGAAGCCGCGCGC
CAGAAAGCGTGGCCGATGACGCTGCGTATTCAGCCGGGATATGATCACAGTTACTACTTC
ATCGCCTCTTTTATAGAGGATCACCTGCGCTTCCATGCGCAGTATTTACTGAAGTGA
Protein Properties
Pfam Domain Function:
Protein Residues:278
Protein Molecular Weight:31076
Protein Theoretical pI:6
PDB File:1X8M
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
MDVRQSIHSAHAKTLDTQGLRNEFLVEKVFVADEYTMVYSHIDRIIVGGIMPITKTVSVG
GEVGKQLGVSYFLERRELGVINIGGAGTITVDGQCYEIGHRDALYVGKGAKEVVFASIDT
GTPAKFYYNCAPAHTTYPTKKVTPDEVSPVTLGDNLTSNRRTINKYFVPDVLETCQLSMG
LTELAPGNLWNTMPCHTHERRMEVYFYFNMDDDACVFHMMGQPQETRHIVMHNEQAVISP
SWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVKDLR
References
External Links:
ResourceLink
Uniprot ID:Q46938
Uniprot Name:KDUI_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675268
PDB ID:1X8M
Ecogene ID:EG13096
Ecocyc:EG13096
ColiBase:b2843
Kegg Gene:b2843
EchoBASE ID:EB2899
CCDB:KDUI_ECOLI
BacMap:16130747
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Dunten, P., Jaffe, H., Aksamit, R. R. (1998). "Crystallization of 5-keto-4-deoxyuronate isomerase from Escherichia coli." Acta Crystallogr D Biol Crystallogr 54:678-680. Pubmed: 9761873
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553