Identification
Name:Probable deoxycholate-binding periplasmic protein YgiS
Synonyms:Not Available
Gene Name:ygiS
Enzyme Class:Not Available
Biological Properties
General Function:transmembrane transport
Specific Function:Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
ATP-binding cassette (ABC) transporter complex
periplasmic space
transmembrane transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1608
atgtatacgcgaaatttattatggctggtcagcctggtaagtgcggctcctctctacgct
gctgacgttcccgccaacacaccgctcgccccgcaacaagtctttcgttacaacaatcat
agcgacccaggtacgctcgacccgcaaaaggtggaggagaatactgccgcgcagattgtg
ctggatctgtttgaaggtctggtatggatggacggtgaaggccaggtgcagcccgctcag
gctgaacgctgggagatactggacggcggcaagcgctatattttccatctgcgtagcggt
ttgcagtggtccgacggtcagcctctgacggcagaggattttgtcctcggctggcagcgc
gcggttgacccgaaaacggcaagcccttttgctggctatctggcacaggcgcacattaac
aatgccgcagctattgttgcgggtaaagcagatgttacatcgctgggtgtcaaagcgacg
gatgatcgtactcttgaagttacgcttgagcagccggttccttggttcacgacgatgctc
gcctggccgacgctgttcccggttcctcatcatgtcatcgctaaacatggcgatagctgg
agtaagccagagaacatggtttacaacggtgcctttgtgcttgatcagtgggtagttaac
gaaaagattactgcacgcaaaaatccaaagtaccgcgatgcgcaacatacagtattgcaa
caggttgagtatctggcgctagataattcggtcaccggctataaccgctatcgcgcggga
gaggtcgatctcacctgggttccggcgcagcaaattcccgccattgaaaaatcactgcct
ggcgagctacgaattattccgcgtctgaacagcgaatattacaacttcaaccttgagaaa
ccgccatttaacgatgtgcgagtgcgtcgggcgctatatcttacggttgatcgacagctt
attgcgcaaaaggtactggggttgagaacgcccgcaaccacgctgacgccgccagaggta
aaaggctttagcgcgacgacgttcgatgaactgcaaaagccaatgagtgagcgcgtcgcg
atggcaaaagccttgctgaaacaggcgggatacgacgcctctcatccgctacgctttgag
ctgttctacaacaagtacgatctgcatgaaaagaccgcgatagcgttgtcttccgaatgg
aaaaaatggctgggtgcacaggtgacgctgcgcacaatggagtggaaaacctatcttgat
gcccgacgagccggtgatttcatgctgtctcggcagtcgtgggatgcgacgtacaatgat
gcttccagcttcctgaacacgctcaaaagcgatagtgaagaaaacgtcggtcactggaaa
aatgcgcagtatgacgccttactaaaccaggccacgcagatcactgatgcgacaaagcgt
aatgcgttgtatcagcaggcagaagtgatcatcaaccaacaggcaccgctgattcctatc
tactatcagccgttaatcaaactgcttaaaccctacgttggcggttttccgctgcataat
ccccaggattatgtctacagcaaagagttgtatatcaaggcacattga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:535
Protein Molecular Weight:60693
Protein Theoretical pI:Not Available
Signaling Regions:
  • 1-20
Transmembrane Regions:Not Available
Protein Sequence:
>Probable deoxycholate-binding periplasmic protein YgiS
MYTRNLLWLVSLVSAAPLYAADVPANTPLAPQQVFRYNNHSDPGTLDPQKVEENTAAQIV
LDLFEGLVWMDGEGQVQPAQAERWEILDGGKRYIFHLRSGLQWSDGQPLTAEDFVLGWQR
AVDPKTASPFAGYLAQAHINNAAAIVAGKADVTSLGVKATDDRTLEVTLEQPVPWFTTML
AWPTLFPVPHHVIAKHGDSWSKPENMVYNGAFVLDQWVVNEKITARKNPKYRDAQHTVLQ
QVEYLALDNSVTGYNRYRAGEVDLTWVPAQQIPAIEKSLPGELRIIPRLNSEYYNFNLEK
PPFNDVRVRRALYLTVDRQLIAQKVLGLRTPATTLTPPEVKGFSATTFDELQKPMSERVA
MAKALLKQAGYDASHPLRFELFYNKYDLHEKTAIALSSEWKKWLGAQVTLRTMEWKTYLD
ARRAGDFMLSRQSWDATYNDASSFLNTLKSDSEENVGHWKNAQYDALLNQATQITDATKR
NALYQQAEVIINQQAPLIPIYYQPLIKLLKPYVGGFPLHNPQDYVYSKELYIKAH
References
External Links:
ResourceLink
Uniprot ID:Q46863
Uniprot Name:YGIS_ECOLI
CCDB:YGIS_ECOLI
General Reference:Not Available