D-alanyl-D-alanine dipeptidase (P77790)

Identification
Name:D-alanyl-D-alanine dipeptidase
Synonyms:
  • D-Ala-D-Ala dipeptidase
Gene Name:ddpX
Enzyme Class:
Biological Properties
General Function:Involved in metallopeptidase activity
Specific Function:Hydrolyzes D-Ala-D-Ala. May have a role in cell-wall turnover
Cellular Location:Secreted (Probable)
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.0D-Alanyl-D-alanine + 1.0Water ↔ 1.0D-Alanine
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 2.0Thumb
1.0D-Alanyl-D-alanine + 1.0Water → 2.0D-Alanine
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb
1.0D-Alanyl-D-alanine + 1.0Water → 1.0D-Alanine
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01310D-AlanineMetaboCard
ECMDB03459D-Alanyl-D-alanineMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
cell wall
external encapsulating structure
Function
catalytic activity
dipeptidase activity
exopeptidase activity
hydrolase activity
metallopeptidase activity
peptidase activity
peptidase activity, acting on L-amino acid peptides
Process
macromolecule metabolic process
metabolic process
protein metabolic process
proteolysis
Gene Properties
Blattner:b1488
Gene OrientationCounterclockwise
Centisome Percentage:33.63
Left Sequence End1560519
Right Sequence End1561100
Gene Sequence:
>582 bp
ATGTCGGATACCACCGAACTGGTTGATTTAGCCGTAATCTTCCCTGATCTGGAGATCGAA
TTGAAATACGCCTGCGCTGATAACATCACAGGTAAAGCTATTTATCAGCAAGCGCGTTGT
CTGTTACACAAGGATGCGATTACCGCGCTGGCGAAAAGTATCAGCATCGCCCAGCTGTCA
GGGTTACAACTGGTGATTTACGATGCGTATCGCCCACAACAAGCACAGGCGATGTTGTGG
CAAGCCTGCCCAGACCCGCAATATGTTGTTGATGTGACGGTCGGTTCTAATCACAGCCGT
GGCACGGCGATCGACCTGACGCTTCGTGATGAGCACGGGAACATCCTCGATATGGGCGCA
GGGTTCGATGAAATGCACGAGCGCTCCCATGCCTATCACCCTTCCGTCCCGCCCGCCGCT
CAGCGCAATCGGCTGTTGCTGAATGCGATAATGACTGGTGGCGGTTTTGTCGGTATCTCC
AGCGAATGGTGGCACTTCGAATTACCCCAGGCAGCGAGTTACCCTCTGCTCGCTGATCAA
TTCTCTTGTTTTATATCCCCTGGCACACAGCACGTCAGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:193
Protein Molecular Weight:21213
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>D-alanyl-D-alanine dipeptidase
MSDTTELVDLAVIFPDLEIELKYACADNITGKAIYQQARCLLHKDAITALAKSISIAQLS
GLQLVIYDAYRPQQAQAMLWQACPDPQYVVDVTVGSNHSRGTAIDLTLRDEHGNILDMGA
GFDEMHERSHAYHPSVPPAAQRNRLLLNAIMTGGGFVGISSEWWHFELPQAASYPLLADQ
FSCFISPGTQHVS
References
External Links:
ResourceLink
Uniprot ID:P77790
Uniprot Name:DDPX_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1742428
Ecogene ID:EG13791
Ecocyc:EG13791
ColiBase:b1488
Kegg Gene:b1488
EchoBASE ID:EB3552
CCDB:DDPX_ECOLI
BacMap:16129447
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Lessard, I. A., Pratt, S. D., McCafferty, D. G., Bussiere, D. E., Hutchins, C., Wanner, B. L., Katz, L., Walsh, C. T. (1998). "Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function." Chem Biol 5:489-504. Pubmed: 9751644