| Identification |
|---|
| Name: | Mechanosensitive channel MscK |
|---|
| Synonyms: | Not Available |
|---|
| Gene Name: | mscK |
|---|
| Enzyme Class: | Not Available |
|---|
| Biological Properties |
|---|
| General Function: | transmembrane transport |
|---|
| Specific Function: | Mechanosensitive channel that opens in response to membrane tension and specific ionic conditions. Requires high concentrations of external K(+), NH(4)(+), Rb(+) or Cs(+) to gate. May participate in the regulation of osmotic pressure changes within the cell, although it does not appear to have a major role in osmolarity regulation. Forms an ion channel of 1.0 nanosiemens conductance. The channel can remain active for between 30 seconds and over 3 minutes; it does not desensitize upon extended pressure. Its activity is masked in wild-type cells by the MscS channel. |
|---|
| Cellular Location: | Not Available |
|---|
| SMPDB Pathways: | Not Available |
|---|
| KEGG Pathways: | Not Available |
|---|
| Metabolites: | |
|---|
| GO Classification: | | Function |
|---|
| cellular response to osmotic stress | | cellular water homeostasis | | integral component of membrane | | plasma membrane | | potassium ion transport | | transmembrane transport |
|
|---|
| Gene Properties |
|---|
| Blattner: | Not Available |
|---|
| Gene Orientation | Not Available |
|---|
| Centisome Percentage: | Not Available |
|---|
| Left Sequence End | Not Available |
|---|
| Right Sequence End | Not Available |
|---|
| Gene Sequence: | >3363
atgactatgttccagtattacaaacgatcacggcattttgttttttcagcatttattgct
tttgtttttgtcttgttatgccagaacacggcgtttgcgcgggcgtcatcgaatggtgat
ctgccgacaaaagcggacctgcaggcgcaacttgactcactaaataaacaaaaagatctt
tctgctcaggacaaactggtgcagcaggatctgacagatacattagccaccctcgataaa
atcgatcgcataaaagaagagacagttcagctacggcaaaaagtcgctgaagcgccggaa
aaaatgcgccaggcgaccgcggcgttaacagcacttagcgatgtcgataacgacgaagaa
acgcgcaaaattctgagcacgctgtcgttgcgccagctggaaactcgcgttgcccaggcg
ctggacgatttgcaaaacgcacaaaacgatctggcgtcttataacagccagctggtttcg
ttacagacgcagcccgaacgcgtgcaaaatgcgatgtataacgcttcgcagcagctgcaa
caaattcgcagtcgtctggatgggactgatgtcggcgagacagccttacgtcccagccag
aaagtgttaatgcaggcccagcaggcgttgctgaatgcggagattgaccagcagcgtaaa
agcctggaagggaacaccgtcttgcaggataccttgcaaaagcaacgtgattacgtgacg
gcgaacagcgctcgtctggagcaccagttacaactgttgcaagaagcggtaaacagcaag
cgcctgactttaaccgaaaaaacggcgcaggaagccgtctccccggatgaagccgcgcgt
attcaggctaatccgctggtgaagcaggaactggaaattaaccagcagttaagtcagcgt
ctgattaccgcgactgaaaacggtaatcagttgatgcagcaaaacattaaagtcaaaaac
tggctggagcgggcgctgcaatcggaacgcaatattaaagagcagattgccgtcctgaag
ggcagcctgctgttgtctcgtatcctttaccagcaacaacaaacgctgccctcggcggat
gaactggaaaacatgaccaaccgcatcgcggatttgcgtctcgaacagtttgaagttaac
cagcagcgtgatgcactcttccagagcgatgcgttcgtcaacaaactggaagaaggtcac
accaacgaagtcaacagcgaagttcacgatgcgttattgcaagtggttgatatgcgtcgc
gaattgctggatcaactcaacaaacagttgggtaaccagctgatgatggccattaacctg
caaatcaaccagcagcagttaatgagtgtgtcgaaaaacctgaaatccatcctgactcag
caaatcttttgggtgaacagtaaccgtccaatggactgggactggatcaaagcgttcccg
caaagcctgaaagatgaatttaagtcgatgaaaatcacggtgaactggcaaaaagcctgg
cccgccgtttttatcgctttcctcgctggtttgccgctgctgttgattgccgggctgatc
cactggcgtctgggctggctgaaagcgtatcaacaaaaactggcttccgctgtgggttcc
ctgcgtaacgacagccagctcaacacaccaaaagcgatccttatcgacctgatccgtgcg
ctgccggtgtgcctgattattctcgcggttggcctgattctgttgaccatgcagctcaac
atcagcgaactgctatggtcgttcagcaaaaaactggcgatattctggctggtgtttggc
ctgtgctggaaggtactggagaaaaacggcgttgccgtacgtcacttcggcatgccggaa
cagcagaccagccactggcgtcggcaaattgtccgcatcagtctcgcattgctgcctatc
catttctggtctgtggtggcagaactttccccgctgcatctgatggatgatgtgctgggg
caagcgatgattttcttcaacctgctgctgattgccttcctggtatggccgatgtgccgc
gaaagctggcgtgataaagagtcgcacaccatgcgactggtcaccattaccgtgctgtcg
ataatcccgattgcgctgatggtgctgactgctacaggctacttctacactacgctgcgt
ctggcaggacgctggattgaaaccgtttatctggtgatcatctggaacctgctgtaccag
acggtactgcgtggcttaagcgtagcggcgcggcgtatcgcctggcgtcgtgcgctggcg
cgtcggcagaatctggtgaaagagggcgcagaaggtgctgaaccgccggaagaacccacc
attgcactggagcaagttaaccagcagacgctgcgtattaccatgttgctgatgtttgcg
ctgttcggtgtcatgttctgggcaatttggtccgatttgatcaccgtgttcagctatctc
gacagcatcacgctctggcattacaacggcactgaagctggcgctgcggtggtgaaaaac
gtcaccatgggcagtctgttgtttgcgattatcgcctcaatggtggcctgggcgttgatt
cgcaacctgcctggtttactggaagtgctggtgctctcgcgactgaatatgcgccagggc
gcgtcgtatgccattactaccatccttaactacatcattattgctgttggtgcgatgacg
gtgttcggatcgctgggcgtctcttgggataaactccagtggctggccgcagcattatcc
gtaggtcttggttttggtttacaagaaattttcggtaacttcgtctccggtttgatcatt
ctattcgaacgtccggtgcgtattggcgatacggtaaccattggtagcttctcggggacg
gtaagtaagatccgtattcgtgcgacaacgattaccgatttcgatcgcaaagaagtgatc
atcccgaacaaagcgtttgttaccgagcgtctgatcaactggtcgttgactgacactact
acgcgtctggtgatccgtctcggcgtggcctatggctccgatctggaaaaagtgcgtaaa
gtgttactgaaggcggcgactgagcacccaagggtgatgcacgaaccaatgccggaagtc
ttctttacggcatttggtgccagcacgttggatcatgagctgcgtctgtatgtgcgtgaa
ctgcgtgaccgtagtcgtactgtcgatgagctgaaccgtactatcgatcagctgtgccgt
gaaaacgacatcaacattgcctttaaccagcttgaagtgcatctgcacaacgagaagggc
gatgaggtgacggaagtaaaacgcgactacaaaggcgatgacccgacgccagcggtaggg
taa |
|---|
| Protein Properties |
|---|
| Pfam Domain Function: | Not Available |
|---|
| Protein Residues: | 1120 |
|---|
| Protein Molecular Weight: | 127214 |
|---|
| Protein Theoretical pI: | Not Available |
|---|
| Signaling Regions: | |
|---|
| Transmembrane Regions: | - 500-520
- 561-581
- 583-603
- 635-655
- 658-678
- 693-713
- 729-749
- 797-817
- 840-860
- 887-907
- 922-942
|
|---|
| Protein Sequence: | >Mechanosensitive channel MscK
MTMFQYYKRSRHFVFSAFIAFVFVLLCQNTAFARASSNGDLPTKADLQAQLDSLNKQKDL
SAQDKLVQQDLTDTLATLDKIDRIKEETVQLRQKVAEAPEKMRQATAALTALSDVDNDEE
TRKILSTLSLRQLETRVAQALDDLQNAQNDLASYNSQLVSLQTQPERVQNAMYNASQQLQ
QIRSRLDGTDVGETALRPSQKVLMQAQQALLNAEIDQQRKSLEGNTVLQDTLQKQRDYVT
ANSARLEHQLQLLQEAVNSKRLTLTEKTAQEAVSPDEAARIQANPLVKQELEINQQLSQR
LITATENGNQLMQQNIKVKNWLERALQSERNIKEQIAVLKGSLLLSRILYQQQQTLPSAD
ELENMTNRIADLRLEQFEVNQQRDALFQSDAFVNKLEEGHTNEVNSEVHDALLQVVDMRR
ELLDQLNKQLGNQLMMAINLQINQQQLMSVSKNLKSILTQQIFWVNSNRPMDWDWIKAFP
QSLKDEFKSMKITVNWQKAWPAVFIAFLAGLPLLLIAGLIHWRLGWLKAYQQKLASAVGS
LRNDSQLNTPKAILIDLIRALPVCLIILAVGLILLTMQLNISELLWSFSKKLAIFWLVFG
LCWKVLEKNGVAVRHFGMPEQQTSHWRRQIVRISLALLPIHFWSVVAELSPLHLMDDVLG
QAMIFFNLLLIAFLVWPMCRESWRDKESHTMRLVTITVLSIIPIALMVLTATGYFYTTLR
LAGRWIETVYLVIIWNLLYQTVLRGLSVAARRIAWRRALARRQNLVKEGAEGAEPPEEPT
IALEQVNQQTLRITMLLMFALFGVMFWAIWSDLITVFSYLDSITLWHYNGTEAGAAVVKN
VTMGSLLFAIIASMVAWALIRNLPGLLEVLVLSRLNMRQGASYAITTILNYIIIAVGAMT
VFGSLGVSWDKLQWLAAALSVGLGFGLQEIFGNFVSGLIILFERPVRIGDTVTIGSFSGT
VSKIRIRATTITDFDRKEVIIPNKAFVTERLINWSLTDTTTRLVIRLGVAYGSDLEKVRK
VLLKAATEHPRVMHEPMPEVFFTAFGASTLDHELRLYVRELRDRSRTVDELNRTIDQLCR
ENDINIAFNQLEVHLHNEKGDEVTEVKRDYKGDDPTPAVG |
|---|
| References |
|---|
| External Links: | |
|---|
| General Reference: | Not Available |
|---|
