| Identification |
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| Name: | Macrolide export protein MacA |
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| Synonyms: | Not Available |
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| Gene Name: | macA |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | response to antibiotic |
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| Specific Function: | Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), suggesting that the system could also transport R-LPS or a similar glycolipid. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| drug export | | extrinsic component of membrane | | identical protein binding | | integral component of membrane | | plasma membrane | | response to antibiotic | | substrate-specific transmembrane transporter activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1116
atgaaaaagcggaaaaccgtgaagaagcgttacgttattgcgctggtgatagtcatcgcc
ggactgattacgttatggagaattcttaacgcacccgtgccgacttatcagacgctgatt
gtgcgccccggtgatttacagcaaagcgtgctggcgaccggaaagctggacgcgctgcgt
aaggttgatgtgggcgcgcaggtcagcggtcagttgaaaactctgtcggtggcgattggc
gataaagtaaaaaaagaccagcttttaggggttattgatcctgaacaggctgaaaaccag
attaaggaggtcgaagcaacgctgatggagctacgtgcgcagcggcagcaggcggaagcg
gagctgaaactggcgcgggtgacgtattcccgtcagcaacgtctggcacaaacgaaggct
gtttcacagcaggatctcgacaccgccgcgacggagatggctgtgaaacaggcgcaaatt
ggcaccattgacgcgcaaatcaagcgcaatcaggcttctctcgatacggctaaaaccaat
ctcgattacactcgcatcgttgccccgatggccggggaagtcacgcaaatcaccactctg
caaggccagacggtgattgccgcacaacaagcaccgaacattctgacgctggcagatatg
agcgccatgctggtaaaagcgcaggtttctgaagcggatgtaatccacctgaagccgggg
caaaaagcctggtttacggtgcttggcgatccactgacgcgctacgaggggcaaatcaag
gatgtactaccgacgccggaaaaggttaacgacgctattttctattacgcccgttttgaa
gtccccaaccccaatggtttgctgcggctggatatgactgcgcaagtgcatattcagctc
accgatgtgaaaaatgtgctgacgatccctctgtcggcgttaggcgatccggttggcgat
aatcgttataaagtcaaattgttgcgtaatggtgaaacacgcgagcgtgaagtgacgatt
ggcgcacgtaacgataccgatgttgagattgtcaaagggcttgaagcgggcgatgaagtg
gtgattggtgaggccaaaccaggagctgcacaatga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 371 |
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| Protein Molecular Weight: | 40623 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 3FPP |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Macrolide export protein MacA
MKKRKTVKKRYVIALVIVIAGLITLWRILNAPVPTYQTLIVRPGDLQQSVLATGKLDALR
KVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEA
ELKLARVTYSRQQRLAQTKAVSQQDLDTAATEMAVKQAQIGTIDAQIKRNQASLDTAKTN
LDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSAMLVKAQVSEADVIHLKPG
QKAWFTVLGDPLTRYEGQIKDVLPTPEKVNDAIFYYARFEVPNPNGLLRLDMTAQVHIQL
TDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEV
VIGEAKPGAAQ |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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