UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase (P71241)

Identification
Name:UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
Synonyms:Not Available
Gene Name:wcaJ
Enzyme Class:
Biological Properties
General Function:lipopolysaccharide biosynthetic process
Specific Function:Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0UDP-Glucose + 1.0Di-trans,poly-cis-undecaprenyl phosphate ↔ 1.0Uridine 5'-monophosphate + 1.0alpha-D-Glucopyranosyl-diphospho-ditrans,octacis-undecaprenol
ReactionCard
Metabolites:
ECMDB IDNameView
GO Classification:
Function
colanic acid biosynthetic process
integral component of membrane
lipopolysaccharide biosynthetic process
plasma membrane
transferase activity, transferring glycosyl groups
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1395
atgacaaatctaaaaaagcgcgagcgagcgaaaaccaatgcatcgttaatctctatggtg
caacgcttttcagatatcaccatcatgtttgccggactatggctggtttgcgaagtcagc
ggactgtcattcctctacatgcacctgttggtggcgctgattacgctggtggtgttccag
atgctgggcggcatcaccgatttttatcgctcatggcgcggtgttcgggcagcgacagaa
tttgccctgttgctacaaaactggaccttaagcgtgattttcagcgccggactggtggcg
ttcaacaatgatttcgacacgcaactgaaaatctggctggcgtggtatgcgctgaccagc
atcggactggtggtttgccgttcgtgtattcgcattggggcgggctggctgcgtaatcat
ggctataacaagcgcatggtcgcggtggcgggggatttagccgccgggcaaatgctgatg
gagagcttccgtaaccagccgtggttagggtttgaagtggtgggcgtttaccacgacccg
aaaccgggcggcgtttctaacgactgggcgggtaacctgcaacagctggtcgaggacgcg
aaagcgggcaagattcataacgtctatatcgcgatgcaaatgtgcgacggcgcgcgagtg
aaaaaactggtccatcaactggcggacaccacctgttcggtgctgctgatccccgacgtc
tttaccttcaacattctccattcacgcctcgaagagatgaacggcgtaccggtggtgccg
ctttacgacacgccgctttccggggttaaccgcctgctcaaacgtgcggaagacattgtg
ctggcgacgcttattctgctgctgatctccccggtgctgtgctgtattgcgctggcggtg
aaactcagttcaccagggccggttattttccgccagactcgctacggcatggatggcaag
ccgatcaaagtgtggaagttccgttccatgaaagtgatggagaacgacaaagtggtgacc
caggcgacgcagaacgatccgcgcgtcaccaaagtggggaactttctgcgccgtacctcg
ctggatgaattgccgcagtttatcaatgtgctgaccggggggatgtcgattgtcggtcca
cgtccgcacgcagtagcgcataacgaacagtatcgacagctcattgaaggctacatgctg
cgccataaggtgaaaccgggcattaccggctgggcgcagattaacggctggcgcggcgaa
accgacacgctggagaaaatggaaaaacgcgtcgagttcgaccttgagtacatccgcgaa
tggagcgtctggttcgatatcaaaatcgttttcctgacggtgttcaaaggtttcgttaac
aaagcggcatattga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:464
Protein Molecular Weight:52408
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:
  • 16-36
  • 39-59
  • 81-101
  • 105-125
  • 279-299
Protein Sequence:
>UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
MTNLKKRERAKTNASLISMVQRFSDITIMFAGLWLVCEVSGLSFLYMHLLVALITLVVFQ
MLGGITDFYRSWRGVRAATEFALLLQNWTLSVIFSAGLVAFNNDFDTQLKIWLAWYALTS
IGLVVCRSCIRIGAGWLRNHGYNKRMVAVAGDLAAGQMLMESFRNQPWLGFEVVGVYHDP
KPGGVSNDWAGNLQQLVEDAKAGKIHNVYIAMQMCDGARVKKLVHQLADTTCSVLLIPDV
FTFNILHSRLEEMNGVPVVPLYDTPLSGVNRLLKRAEDIVLATLILLLISPVLCCIALAV
KLSSPGPVIFRQTRYGMDGKPIKVWKFRSMKVMENDKVVTQATQNDPRVTKVGNFLRRTS
LDELPQFINVLTGGMSIVGPRPHAVAHNEQYRQLIEGYMLRHKVKPGITGWAQINGWRGE
TDTLEKMEKRVEFDLEYIREWSVWFDIKIVFLTVFKGFVNKAAY
References
External Links:
ResourceLink
Uniprot ID:P71241
Uniprot Name:WCAJ_ECOLI
CCDB:WCAJ_ECOLI
General Reference:Not Available