Probable N-acetylneuraminic acid outer membrane channel protein nanC (P69856)

Identification
Name:Probable N-acetylneuraminic acid outer membrane channel protein nanC
Synonyms:
  • NanR-regulated channel
  • Porin nanC
Gene Name:nanC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in oligosaccharide transporting porin activity
Specific Function:Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac or sialic acid) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity
Cellular Location:Cell outer membrane
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB00830N-Acetylneuraminic acidMetaboCard
GO Classification:Not Available
Gene Properties
Blattner:b4311
Gene OrientationCounterclockwise
Centisome Percentage:97.78
Left Sequence End4536808
Right Sequence End4537524
Gene Sequence:
>717 bp
ATGAGACTCGAGTTTTCAATTTATCGCTATAACCCGGATGTTGATGATGCTCCGCGTATG
CAGGATTACACCCTGGAAGCGGATGAAGGTCGCGACATGATGCTGCTGGATGCGCTTATC
CAGCTAAAAGAGAAAGATCCCAGCCTGTCGTTCCGCCGCTCCTGCCGTGAAGGTGTGTGC
GGTTCCGACGGTCTGAACATGAACGGCAAGAATGGTCTGGCCTGTATTACCCCGATTTCG
GCACTCAACCAGCCGGGCAAGAAGATTGTGATTCGCCCGCTGCCAGGTTTACCGGTGATC
CGCGATTTGGTGGTAGACATGGGACAATTCTATGCGCAATATGAGAAAATTAAGCCTTAC
CTGTTGAATAATGGACAAAATCCGCCAGCTCGCGAGCATTTACAGATGCCAGAGCAGCGC
GAAAAACTCGACGGGCTGTATGAATGTATTCTCTGCGCATGTTGTTCAACCTCTTGTCCG
TCTTTCTGGTGGAATCCCGATAAGTTTATCGGCCCGGCAGGCTTGTTAGCGGCATATCGT
TTCCTGATTGATAGCCGTGATACCGAGACTGACAGCCGCCTCGACGGTTTGAGTGATGCA
TTCAGCGTATTCCGCTGTCACAGCATCATGAACTGCGTCAGTGTATGTCCGAAGGGGCTG
AACCCGACGCGCGCCATCGGCCATATCAAGTCGATGTTGTTGCAACGTAATGCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:238
Protein Molecular Weight:27888
Protein Theoretical pI:9
Signaling Regions:
  • 1-23
Transmembrane Regions:
  • None
Protein Sequence:
>Probable N-acetylneuraminic acid outer membrane channel protein nanC
MKKAKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESN
TWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDAT
KDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDY
RYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
References
External Links:
ResourceLink
Uniprot ID:P69856
Uniprot Name:NANC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651320
Ecogene ID:EG12389
Ecocyc:EG12389
ColiBase:b4311
Kegg Gene:b4311
EchoBASE ID:EB2290
CCDB:NANC_ECOLI
BacMap:90111728
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Condemine, G., Berrier, C., Plumbridge, J., Ghazi, A. (2005). "Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli." J Bacteriol 187:1959-1965. Pubmed: 15743943
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553