D,D-heptose 1,7-bisphosphate phosphatase (P63228)

Identification
Name:D,D-heptose 1,7-bisphosphate phosphatase
Synonyms:
  • D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase
Gene Name:gmhB
Enzyme Class:
Biological Properties
General Function:Involved in phosphatase activity
Specific Function:Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position
Cellular Location:Cytoplasm
SMPDB Pathways:
  • ADP-L-glycero-Beta-D-manno-heptose biosynthesis PW002095
  • Lipopolysaccharide biosynthesis PW000831
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0D-Glycero-D-manno-heptose 1,7-bisphosphate + 1.0Water ↔ 1.0D-Glycero-D-manno-heptose 1-phosphate + 1.0Phosphate
ReactionCard
1.0D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate+1.0Thumb ↔ 1.0D-glycero-alpha-D-manno-Heptose 1-phosphate+1.0Thumb
1.0D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate + 1.0Water ↔ 1.0D-glycero-alpha-D-manno-Heptose 1-phosphate + 1.0Phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0D-glycero-beta-D-manno-heptose 1-phosphate+1.0Thumb
1.0D-Glycero-D-manno-heptose 1,7-bisphosphate + 1.0Water → 1.0D-glycero-beta-D-manno-heptose 1-phosphate + 1.0Phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 1.0D-glycero-β-D-manno-heptose 1-phosphate+1.0Thumb
1.0D-Glycero-D-manno-heptose 1,7-bisphosphate + 1.0Water → 1.0D-glycero-β-D-manno-heptose 1-phosphate + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21199D-Glycero-D-manno-heptose 1,7-bisphosphateMetaboCard
ECMDB21200D-Glycero-D-manno-heptose 1-phosphateMetaboCard
ECMDB21380Inorganic phosphateMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
histidinol-phosphatase activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphatase activity
phosphoric ester hydrolase activity
Process
carbohydrate metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
histidine biosynthetic process
histidine family amino acid metabolic process
histidine metabolic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b0200
Gene OrientationClockwise
Centisome Percentage:4.80
Left Sequence End222833
Right Sequence End223408
Gene Sequence:
>576 bp
GTGGCGAAGAGCGTACCCGCAATTTTTCTTGACCGTGATGGCACCATTAATGTCGATCAC
GGCTATGTCCATGAGATCGACAACTTTGAATTTATCGACGGTGTTATTGACGCCATGCGC
GAGCTAAAAAAAATGGGCTTTGCGCTGGTGGTAGTAACCAACCAGTCTGGCATTGCTCGC
GGTAAATTTACCGAAGCACAGTTTGAAACGCTGACCGAGTGGATGGACTGGTCGCTGGCG
GACCGAGATGTCGATCTGGATGGTATCTATTATTGCCCGCATCATCCGCAGGGTAGTGTT
GAAGAGTTTCGCCAGGTCTGCGATTGCCGCAAACCACATCCGGGGATGCTTTTGTCAGCA
CGCGATTATTTGCATATTGATATGGCCGCTTCTTATATGGTGGGCGATAAATTAGAAGAT
ATGCAGGCAGCGGTTGCGGCGAACGTGGGAACAAAAGTGCTGGTGCGTACGGGTAAACCT
ATTACGCCTGAAGCAGAAAACGCGGCGGATTGGGTGTTAAATAGCCTGGCAGACCTGCCG
CAAGCGATAAAAAAGCAGCAAAAACCGGCACAATGA
Protein Properties
Pfam Domain Function:
Protein Residues:191
Protein Molecular Weight:21294
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>D,D-heptose 1,7-bisphosphate phosphatase
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIAR
GKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSA
RDYLHIDMAASYMVGDKLEDMQAAVAANVGTKVLVRTGKPITPEAENAADWVLNSLADLP
QAIKKQQKPAQ
References
External Links:
ResourceLink
Uniprot ID:P63228
Uniprot Name:GMHB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4902943
Ecogene ID:EG11736
Ecocyc:EG11736
ColiBase:b0200
Kegg Gene:b0200
EchoBASE ID:EB1687
CCDB:GMHB_ECOLI
BacMap:16128193
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M. A., Messner, P. (2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli." J Bacteriol 184:363-369. Pubmed: 11751812