| Identification |
|---|
| Name: | 50S ribosomal protein L5 |
|---|
| Synonyms: | Not Available |
|---|
| Gene Name: | rplE |
|---|
| Enzyme Class: | Not Available |
|---|
| Biological Properties |
|---|
| General Function: | translation |
|---|
| Specific Function: | This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. Its 5S rRNA binding is significantly enhanced in the presence of L18.In the 70S ribosome in the initiation state (PubMed:12809609) was modeled to contact protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; the protein-protein contacts between S13 and L5 in B1b change in the model with bound EF-G implicating this bridge in subunit movement (PubMed:12809609 and PubMed:18723842). In the two 3.5 A resolved ribosome structures (PubMed:16272117) the contacts between L5, S13 and S19 are different, confirming the dynamic nature of this interaction.Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. |
|---|
| Cellular Location: | Not Available |
|---|
| SMPDB Pathways: | Not Available |
|---|
| KEGG Pathways: | |
|---|
| Metabolites: | |
|---|
| GO Classification: | | Function |
|---|
| cytosolic large ribosomal subunit | | rRNA binding | | structural constituent of ribosome | | translation | | tRNA binding |
|
|---|
| Gene Properties |
|---|
| Blattner: | Not Available |
|---|
| Gene Orientation | Not Available |
|---|
| Centisome Percentage: | Not Available |
|---|
| Left Sequence End | Not Available |
|---|
| Right Sequence End | Not Available |
|---|
| Gene Sequence: | >540
atggcgaaactgcatgattactacaaagacgaagtagttaaaaaactcatgactgagttt
aactacaattctgtcatgcaagtccctcgggtcgagaagatcaccctgaacatgggtgtt
ggtgaagcgatcgctgacaaaaaactgctggataacgcagcagcagacctggcagcaatc
tccggtcaaaaaccgctgatcaccaaagcacgcaaatctgttgcaggcttcaaaatccgt
cagggctatccgatcggctgtaaagtaactctgcgtggcgaacgcatgtgggagttcttt
gagcgcctgatcactattgctgtacctcgtatccgtgacttccgtggcctgtccgctaag
tctttcgacggtcgtggtaactacagcatgggtgtccgtgagcagatcatcttcccagaa
atcgactacgataaagtcgaccgcgttcgtggtttggatattaccattaccactactgcg
aaatctgacgaagaaggccgcgctctgctggctgcctttgacttcccgttccgcaagtaa
|
|---|
| Protein Properties |
|---|
| Pfam Domain Function: | Not Available |
|---|
| Protein Residues: | 179 |
|---|
| Protein Molecular Weight: | 20301 |
|---|
| Protein Theoretical pI: | Not Available |
|---|
| PDB File: | 1ML5 |
| Signaling Regions: | Not Available |
|---|
| Transmembrane Regions: | Not Available |
|---|
| Protein Sequence: | >50S ribosomal protein L5
MAKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAI
SGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAK
SFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFRK |
|---|
| References |
|---|
| External Links: | |
|---|
| General Reference: | Not Available |
|---|
