ECMDB

Identification

Name:

Secretion monitor

Synonyms:

Not Available

Gene Name:

secM

Enzyme Class:

Not Available

Biological Properties

General Function:

regulation of translation

Specific Function:

Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Protein export eco03060

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cytosol
periplasmic space
regulation of translation
translation regulator activity

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>513
gtgagtggaatactgacgcgctggcgacagtttggtaaacgctacttctggccgcatctc
ttattagggatggttgcggcgagtttaggtttgcctgcgctcagcaacgccgccgaacca
aacgcgcccgcaaaagcgacaacccgcaaccacgagccttcagccaaagttaactttggt
caattggccttgctggaagcgaacacacgccgcccgaattcgaactattccgttgattac
tggcatcaacatgccattcgcacggtaatccgtcatctttctttcgcaatggcaccgcaa
acactgcccgttgctgaagaatctttgcctcttcaggcgcaacatcttgcattactggat
acgctcagcgcgctgctgacccaggaaggcacgccgtctgaaaagggttatcgcattgat
tatgcgcattttaccccacaagcaaaattcagcacgcccgtctggataagccaggcgcaa
ggcatccgtgctggccctcaacgcctcacctaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

170

Protein Molecular Weight:

18879

Protein Theoretical pI:

Not Available

Signaling Regions:

1-37

Transmembrane Regions:

Not Available

Protein Sequence:

>Secretion monitor
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFG
QLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLD
TLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

References

External Links:

Resource	Link
Uniprot ID:	P62395
Uniprot Name:	SECM_ECOLI
CCDB:	SECM_ECOLI

General Reference:

Not Available

Secretion monitor (P62395)