| Identification |
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| Name: | Secretion monitor |
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| Synonyms: | Not Available |
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| Gene Name: | secM |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | regulation of translation |
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| Specific Function: | Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cytosol | | periplasmic space | | regulation of translation | | translation regulator activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >513
gtgagtggaatactgacgcgctggcgacagtttggtaaacgctacttctggccgcatctc
ttattagggatggttgcggcgagtttaggtttgcctgcgctcagcaacgccgccgaacca
aacgcgcccgcaaaagcgacaacccgcaaccacgagccttcagccaaagttaactttggt
caattggccttgctggaagcgaacacacgccgcccgaattcgaactattccgttgattac
tggcatcaacatgccattcgcacggtaatccgtcatctttctttcgcaatggcaccgcaa
acactgcccgttgctgaagaatctttgcctcttcaggcgcaacatcttgcattactggat
acgctcagcgcgctgctgacccaggaaggcacgccgtctgaaaagggttatcgcattgat
tatgcgcattttaccccacaagcaaaattcagcacgcccgtctggataagccaggcgcaa
ggcatccgtgctggccctcaacgcctcacctaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 170 |
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| Protein Molecular Weight: | 18879 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Secretion monitor
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFG
QLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLD
TLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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