H(+)/Cl(-) exchange transporter ClcA (P58244)

Identification
Name:H(+)/Cl(-) exchange transporter ClcA
Synonyms:Not Available
Gene Name:clcA
Enzyme Class:Not Available
Biological Properties
General Function:Involved in ion channel activity
Specific Function:Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
Cellular Location:Cell inner membrane; Multi-pass membrane protein (Probable)
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Component
cell part
membrane
Function
anion channel activity
chloride channel activity
ion channel activity
ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
voltage-gated chloride channel activity
Process
anion transport
chloride transport
establishment of localization
inorganic anion transport
ion transport
transmembrane transport
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1422 bp
ATGAAAACTGATACTCCCTCTTTAGAAACACCGCAGGCCGCGCGCCTGCGACGCAGACAA
CTGATTCGCCAACTTCTTGAGCGCGATAAAACCCCGTTAGCCATTTTGTTTATGGCGGCA
GTCGTCGGCACGCTTGTCGGGCTGGCAGCGGTTGCTTTTGACAAAGGTGTCGCCTGGTTG
CAGAACCAACGTATGGGGGCGCTGGTACATACTGCTGATAATTATCCGCTACTGTTAACC
GTTGCTTTTCTCTGTTCGGCGGTGCTGGCGATGTTCGGCTACTTTTTGGTGCGCAAATAC
GCGCCCGAAGCAGGGGGGTCGGGGATCCCGGAAATTGAAGGGGCGCTGGAAGATCAACGT
CCTGTTCGCTGGTGGCGTGTATTGCCGGTGAAATTCTTTGGCGGGCTGGGGACACTCGGC
GGAGGCATGGTGTTGGGGCGCGAAGGGCCAACCGTGCAGATCGGCGGTAATATCGGGCGG
ATGGTACTCGATGTTTTCCGCCTGAAAGGTGATGAAGCTCGCCATACGCTGTTGGCAACC
GGTGCGGCGGCGGGTCTGGCGGCGGCCTTTAACGCGCCGCTGGCGGGTATTTTGTTTATT
ATCGAAGAGATGCGTCCGCAGTTTCGCTATACGTTAATTTCGATTAAAGCGGTATTTATT
GSCGTCATTATGTCGACCATTATGTACCGGATTTTTAATCATGAAGTTGCGTTGATTGAC
GTCGGTAAACTTTCTGACGCGCCGCTTAATACGCTGTGGCTTTATCTGATCCTCGGTATT
ATTTTTGGCATTTTCGGCCCTATTTTTAATAAATGGGTGCTGGGGATGCAGGATTTGCTG
CACCGTGTGCACGGTGGCAATATTACCAAATGGGTACTGATGGGTGGTGCGATTGGCGGT
CTGTGTGGATTGCTGGGGTTTGTGGCACCAGCAACGTCGGGCGGCGGTTTTAACCTGATT
CCTATCGCTACCGCGGGGAATTTCAGCATGGGAATGCTGGTGTTTATCTTCGTCGCGCGG
GTCATTACCACCTTACTCTGCTTCTCTTCCGGCGCGCCGGGCGGTATTTTTGCCCCGATG
CTGGCGCTGGGTACTGTGCTGGGAACCGCTTTCGGAATGGTTGCCGTTGAGCTGTTTCCG
CAATATCACCTTGAGGCGGGGACGTTTGCTATTGCCGGAATGGGGGCGTTACTGGCGGCA
TCTATTCGCGCGCCGTTAACGGGGATCATTCTGGTTCTGGAGATGACCGATAACTACCAG
CTCATTTTGCCAATGATTATTACCGGTCTTGGCGCAACACTATTAGCGCAATTTACCGGC
GGGAAACCGCTATACTCGGCGATTCTTGCGCGCACGCTGGCAAAACAGGAAGCTGAGCAA
CTGGCGCGAAGCAAGGCCGCATCAGCCAGCGAGAATACTTGA
Protein Properties
Pfam Domain Function:
Protein Residues:473
Protein Molecular Weight:50334
Protein Theoretical pI:10
PDB File:1KPK
Signaling Regions:
  • None
Transmembrane Regions:
  • 33-69
  • 77-100
  • 124-141
  • 148-166
  • 215-232
  • 253-281
  • 288-309
  • 330-349
  • 355-376
  • 422-438
Protein Sequence:
>H(+)/Cl(-) exchange transporter ClcA
MKTDTPSLETPQAARLRRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWL
QNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQR
PVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDVFRLKGDEARHTLLAT
GAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALID
VGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGG
LCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPM
LALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQ
LILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQLARSKAASASENT
References
External Links:
ResourceLink
Uniprot ID:P58244
Uniprot Name:CLCA_ECO57
GenBank Gene ID:AE005174
Genebank Protein ID:12512879
PDB ID:1KPK
EchoBASE ID:EB2235
CCDB:CLCA_ECO57
General Reference:
  • Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H. (2001). "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." DNA Res 8:11-22. Pubmed: 11258796
  • Perna, N. T., Plunkett, G. 3rd, Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., Posfai, G., Hackett, J., Klink, S., Boutin, A., Shao, Y., Miller, L., Grotbeck, E. J., Davis, N. W., Lim, A., Dimalanta, E. T., Potamousis, K. D., Apodaca, J., Anantharaman, T. S., Lin, J., Yen, G., Schwartz, D. C., Welch, R. A., Blattner, F. R. (2001). "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Nature 409:529-533. Pubmed: 11206551