RNA-splicing ligase RtcB (P46850)
| Identification | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Name: | RNA-splicing ligase RtcB | |||||||||
| Synonyms: | Not Available | |||||||||
| Gene Name: | rtcB | |||||||||
| Enzyme Class: | ||||||||||
| Biological Properties | ||||||||||
| General Function: | RNA repair | |||||||||
| Specific Function: | RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP (PubMed:21224389, PubMed:22730297). Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases (PubMed:24218597). | |||||||||
| Cellular Location: | Not Available | |||||||||
| SMPDB Pathways: | Not Available | |||||||||
| KEGG Pathways: | Not Available | |||||||||
| KEGG Reactions: |
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| Metabolites: |
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| GO Classification: |
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| Gene Properties | ||||||||||
| Blattner: | Not Available | |||||||||
| Gene Orientation | Not Available | |||||||||
| Centisome Percentage: | Not Available | |||||||||
| Left Sequence End | Not Available | |||||||||
| Right Sequence End | Not Available | |||||||||
| Gene Sequence: | >1227 atgaattacgaattactgaccactgaaaatgccccggtaaaaatgtggaccaaaggcgtg ccggtagaggccgatgcgcgtcagcaacttattaatacggcgaagatgccgtttattttc aaacatattgcggtaatgcctgatgtacacctgggtaaaggttccaccattggtagcgtg atcccgaccaaaggggcgattattccggcggcggtgggcgtggatattggctgtggaatg aacgcgctgcgtaccgcgttaacggcggaagacctgcctgaaaacctggcagagctgcgt caggcgattgaaacggccgtgccgcacgggcgtaccactggccgttgtaaacgtgataaa ggtgcctgggaaaatccacctgttaacgtcgatgctaaatgggctgagcttgaagccggt tatcagtggttaacgcaaaaatatccccgtttcctgaataccaataactataaacacctg ggaacgctgggaaccggtaaccactttattgaaatctgccttgatgagtcggaccaggtg tggattatgctgcactccggttcacgcggaattggtaacgccatcgggacttactttatc gatctggcacaaaaagagatgcaggaaacgcttgagacgttgccgtcgcgtgatctggcg tactttatggaaggtacggaatactttgatgattacctgaaagccgtggcctgggcgcag ctttttgccagccttaaccgcgatgcgatgatggaaaacgtggtaacggcattgcagagc attacgcagaaaacggtcagacagccacaaacgctggcgatggaagagatcaactgtcac cacaactatgtgcaaaaagaacagcactttggtgaagagatctacgtgacgcgtaaaggc gcggtgtctgcgcgtgctggtcaatatggaattattcccggttcgatgggagcaaaaagc tttatcgtccgtgggctgggaaatgaagagtcgttctgttcgtgcagccacggtgccggg cgggtaatgagccgaactaaagcgaaaaaactgttcagcgtggaagatcaaattcgtgcc accgcgcatgtggaatgccgtaaagatgccgaagtgatcgacgaaatcccgatggcgtat aaagatattgatgcggtgatggcggcacaaagcgatctggtggaagttatctataccctg cgtcaggtggtgtgcgtaaaaggataa | |||||||||
| Protein Properties | ||||||||||
| Pfam Domain Function: | Not Available | |||||||||
| Protein Residues: | 408 | |||||||||
| Protein Molecular Weight: | 45221 | |||||||||
| Protein Theoretical pI: | Not Available | |||||||||
| Signaling Regions: | Not Available | |||||||||
| Transmembrane Regions: | Not Available | |||||||||
| Protein Sequence: | >RNA-splicing ligase RtcB MNYELLTTENAPVKMWTKGVPVEADARQQLINTAKMPFIFKHIAVMPDVHLGKGSTIGSV IPTKGAIIPAAVGVDIGCGMNALRTALTAEDLPENLAELRQAIETAVPHGRTTGRCKRDK GAWENPPVNVDAKWAELEAGYQWLTQKYPRFLNTNNYKHLGTLGTGNHFIEICLDESDQV WIMLHSGSRGIGNAIGTYFIDLAQKEMQETLETLPSRDLAYFMEGTEYFDDYLKAVAWAQ LFASLNRDAMMENVVTALQSITQKTVRQPQTLAMEEINCHHNYVQKEQHFGEEIYVTRKG AVSARAGQYGIIPGSMGAKSFIVRGLGNEESFCSCSHGAGRVMSRTKAKKLFSVEDQIRA TAHVECRKDAEVIDEIPMAYKDIDAVMAAQSDLVEVIYTLRQVVCVKG | |||||||||
| References | ||||||||||
| External Links: |
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| General Reference: | Not Available | |||||||||
