| Identification |
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| Name: | FKBP-type peptidyl-prolyl cis-trans isomerase fkpA |
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| Synonyms: | |
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| Gene Name: | fkpA |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Posttranslational modification, protein turnover, chaperones |
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| Specific Function: | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides |
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| Cellular Location: | Periplasm |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| KEGG Reactions: | |
1.0Peptidylproline (omega=180) | ↔ | 1.0Peptidylproline (omega=0) |
| 1.0Peptidylproline (omega=180) ↔ 1.0Peptidylproline (omega=0) ReactionCard |
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| Metabolites: | |
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| GO Classification: | | Process |
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| cellular protein metabolic process | | macromolecule metabolic process | | metabolic process | | protein folding | | protein metabolic process |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >813 bp
ATGAAATCACTGTTTAAAGTAACGCTGCTGGCGACCACAATGGCCGTTGCCCTGCATGCA
CCAATCACTTTTGCTGCTGAAGCTGCAAAACCTGCTACAGCTGCTGACAGCAAAGCAGCG
TTCAAAAATGACGATCAGAAATCAGCTTATGCACTGGGTGCCTCGCTGGGTCGTTACATG
GAAAACTCTCTAAAAGAACAAGAAAAACTGGGCATCAAACTGGATAAAGATCAGCTGATC
GCTGGTGTTCAGGATGCATTTGCTGATAAGAGCAAACTCTCCGACCAAGAGATCGAACAG
ACTCTACAAGCATTCGAAGCTCGCGTGAAGTCTTCTGCTCAGGCGAAGATGGAAAAAGAC
GCGGCTGATAACGAAGCAAAAGGTAAAGAGTACCGCGAGAAATTTGCCAAAGAGAAAGGT
GTGAAAACCTCTTCAACTGGTCTGGTTTATCAGGTAGTAGAAGCCGGTAAAGGCGAAGCA
CCGAAAGACAGCGATACTGTTGTAGTGAACTACAAAGGTACGCTGATCGACGGTAAAGAG
TTCGACAACTCTTACACCCGTGGTGAACCGCTTTCTTTCCGTCTGGACGGTGTTATCCCG
GGTTGGACAGAAGGTCTGAAGAACATCAAGAAAGGCGGTAAGATCAAACTGGTTATTCCA
CCAGAACTGGCTTACGGCAAAGCGGGTGTTCCGGGGATCCCACCGAATTCTACCCTGGTG
TTTGACGTAGAGCTGCTGGATGTGAAACCAGCGCCGAAGGCTGATGCAAAGCCGGAAGCT
GATGCGAAAGCCGCAGATTCTGCTAAAAAATAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 270 |
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| Protein Molecular Weight: | 28882 |
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| Protein Theoretical pI: | 9 |
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| PDB File: | 1Q6U |
| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >FKBP-type peptidyl-prolyl cis-trans isomerase fkpA
MKSLFKVTLLATTMAVALHAPITFAAEAAKPATAADSKAAFKNDDQKSAYALGASLGRYM
ENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKD
AADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKE
FDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLV
FDVELLDVKPAPKADAKPEADAKAADSAKK |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Horne, S. M., Young, K. D. (1995). "Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins." Arch Microbiol 163:357-365. Pubmed: 7540828
- Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
- Missiakas, D., Betton, J. M., Raina, S. (1996). "New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH." Mol Microbiol 21:871-884. Pubmed: 8878048
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