| Identification |
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| Name: | Miniconductance mechanosensitive channel MscM |
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| Synonyms: | Not Available |
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| Gene Name: | mscM |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transmembrane transport |
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| Specific Function: | Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cellular water homeostasis | | integral component of membrane | | ion transport | | plasma membrane | | transmembrane transport |
|
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >3324
gtgcgcctgattatcacttttctgatggcctggtgcctcagttggggggcgtacgccgcg
acggcccccgatagcaaacaaatcactcaggaactggagcaggcaaaagcggcgaaaccc
gcacagccggaagtcgtagaggcgctccagtctgccttaaatgcgcttgaggaacgaaaa
ggttcccttgagcgcatcaaacaatatcagcaagttatcgataattatccgaaactctcc
gctactctgcgcgcacaattaaacaacatgcgtgacgagccgcgcagcgtgtcgccggga
atgtctaccgacgcgctgaatcaggaaattctccaggtcagcagccagttgctggataaa
agccgtcaggcccagcaagagcaggagcgcgcccgcgagattgccgattcgctgaatcaa
ctgccgcaacagcaaaccgacgcccgccgtcagttaaatgagatcgagcgccgcctggga
acgcttaccggcaatactccgctcaatcaggcacaaaatttcgcgttgcagtctgactct
gcacgtcttaaggcgctcgttgatgaactggagctggcgcagctgtctgccaataaccgc
caggaattagcgcgcttacgctcagagctggcggaaaaagagagccagcaactggatgcg
tatttgcaggccttgcgtaatcaattaaacagccaacgtcagcttgaggcggagcgggcg
ctggaaagtaccgaattgctggcagaaaacagcgccgatttgccgaaagatatcgtcgcg
caattcaaaattaaccgcgaactatcggcggctttgaatcaacaggcgcagcggatggat
ctcgttgcctcgcaacagcgtcaggctgccagccagacgttacaggtccggcaggcgttg
aatacgctgcgtgaacagtcgcaatggctgggatcgtccaatctgctcggcgaagcgctg
cgggcgcaggtggcacggctgccggaaatgccgaaaccacaacagcttgataccgaaatg
gcgcagttgcgtgtgcaacggttacgttatgaggatctgcttaataaacagccgctgcta
cggcaaattcatcaggccgacggtcagccgctgactgccgagcaaaaccgtattctggaa
gcacaactgcgcactcagcgtgagttgctgaactcattgttgcagggtggcgacacgcta
ctattggaactgaccaagctgaaagtctccaacgggcaactggaggatgcgctgaaagag
gtgaacgaagcaacgcaccgctatctgttctggacctctgacgtgcgcccgatgaccatc
gcctggccgctggaaatcgcccaggatctgcgtcgtctcatttcgctggacaccttcagt
cagttgggcaaagccagtgtgatgatgctgaccagcaaagagacaattttgccgctgttt
ggcgcgttgattctggtcggttgcagtatttactcgcgccgctatttcacccgttttctt
gaacgttcggcggcgaaagttggcaaagtgactcaggatcacttctggctgacgttgcgc
actcttttctggtcgattctcgtcgcgtcaccgttaccggtgctgtggatgacgctgggt
tacggcttgcgcgaggcgtggccttatccgctggcggtcgcgattggcgatggtgtaacg
gccaccgtgccgctgctgtgggtagtgatgatttgcgccacctttgcccgcccgaacggc
ttgtttatcgctcattttggctggccgcgcgaacgtgtttcccgtgggatgcgctactac
ctgatgagcatcgggcttattgtgccgctgattatggcgctgatgatgttcgataacctc
gacgaccgtgaattctccggttcgctgggacggctttgctttatcctcatttgcggtgcg
ctggcggtggtcaccctcagcctgaaaaaggccgggattccgctgtatctcaacaaagag
ggcagcggcgacaacattaccaaccatatgctgtggaacatgatgattggcgcgccgttg
gttgccattctggcgtcggcggtgggttatctggcaacggcacaggcgctgttagcgagg
cttgaaacctcggttgccatctggttcctgctactggtggtttatcacgttatccgccgc
tggatgctgatccagcgccgcaggctggcgtttgatcgggcgaagcatcgccgggcagag
atgttagcgcaacgtgcgcgtggcgaagaggaagcgcatcatcacagtagcccggaagga
gcaattgaagtcgatgaaagcgaagtcgatctcgatgccatcagtgcgcaatccttgcgg
ctggtgcgctcaattttgatgttgatcgccctgctttctgtcattgtgctgtggtcagaa
atccattccgctttcggcttcctcgaaaatatttcgctgtgggatgtcacctccacggta
cagggcgtagaaagtctggagccaattaccctcggtgcggtgctgattgccattctggtg
tttatcatcaccacgcagctggtgcgcaacttgcccgcgctgctggaactggcgattttg
cagcacctggatttaacgccgggtacgggttacgccatcaccaccatcaccaaatatctg
ctgatgctgattggcgggctggtcggcttctcaatgattggtattgagtggtcgaaattg
cagtggctggttgccgcgctcggtgttggtctcggttttggtttgcaggaaattttcgcc
aactttatctctggtctgattatcctgttcgaaaaaccgattcgcattggcgatacggtg
acaattcgcgatctcaccggtagcgtgacgaaaattaacacccgcgccaccaccatcagc
gactgggaccgtaaagagataatcgtgccgaacaaggcgtttattaccgagcagtttatc
aactggtcgctctctgactcggtcacgcgcgtggtgttgacgataccggcccctgccgat
gccaatagcgaagaagtgacggaaatcctgctcaccgcagcgcgtcgctgctcgctggtg
atcgacaacccggcaccggaagtcttcctggtggatctgcaacaggggattcagattttc
gagctgcgtatttacgccgctgagatgggtcaccgtatgccgctacgccatgagatccac
cagctgattctggctggcttccatgcccacggtatcgatatgccattcccgcccttccag
atgcgtctggaaagcctcaacggtaaacaaacggggagaacgctgacgtctgcgggcaaa
ggtcgtcaggcgggaagtttgtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 1107 |
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| Protein Molecular Weight: | 123966 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | |
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| Transmembrane Regions: | - 467-487
- 522-542
- 551-571
- 600-620
- 628-648
- 674-694
- 698-718
- 785-805
- 828-848
- 875-895
- 910-930
|
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| Protein Sequence: | >Miniconductance mechanosensitive channel MscM
MRLIITFLMAWCLSWGAYAATAPDSKQITQELEQAKAAKPAQPEVVEALQSALNALEERK
GSLERIKQYQQVIDNYPKLSATLRAQLNNMRDEPRSVSPGMSTDALNQEILQVSSQLLDK
SRQAQQEQERAREIADSLNQLPQQQTDARRQLNEIERRLGTLTGNTPLNQAQNFALQSDS
ARLKALVDELELAQLSANNRQELARLRSELAEKESQQLDAYLQALRNQLNSQRQLEAERA
LESTELLAENSADLPKDIVAQFKINRELSAALNQQAQRMDLVASQQRQAASQTLQVRQAL
NTLREQSQWLGSSNLLGEALRAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPLL
RQIHQADGQPLTAEQNRILEAQLRTQRELLNSLLQGGDTLLLELTKLKVSNGQLEDALKE
VNEATHRYLFWTSDVRPMTIAWPLEIAQDLRRLISLDTFSQLGKASVMMLTSKETILPLF
GALILVGCSIYSRRYFTRFLERSAAKVGKVTQDHFWLTLRTLFWSILVASPLPVLWMTLG
YGLREAWPYPLAVAIGDGVTATVPLLWVVMICATFARPNGLFIAHFGWPRERVSRGMRYY
LMSIGLIVPLIMALMMFDNLDDREFSGSLGRLCFILICGALAVVTLSLKKAGIPLYLNKE
GSGDNITNHMLWNMMIGAPLVAILASAVGYLATAQALLARLETSVAIWFLLLVVYHVIRR
WMLIQRRRLAFDRAKHRRAEMLAQRARGEEEAHHHSSPEGAIEVDESEVDLDAISAQSLR
LVRSILMLIALLSVIVLWSEIHSAFGFLENISLWDVTSTVQGVESLEPITLGAVLIAILV
FIITTQLVRNLPALLELAILQHLDLTPGTGYAITTITKYLLMLIGGLVGFSMIGIEWSKL
QWLVAALGVGLGFGLQEIFANFISGLIILFEKPIRIGDTVTIRDLTGSVTKINTRATTIS
DWDRKEIIVPNKAFITEQFINWSLSDSVTRVVLTIPAPADANSEEVTEILLTAARRCSLV
IDNPAPEVFLVDLQQGIQIFELRIYAAEMGHRMPLRHEIHQLILAGFHAHGIDMPFPPFQ
MRLESLNGKQTGRTLTSAGKGRQAGSL |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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