UDP-galactopyranose mutase (P37747)

Identification
Name:UDP-galactopyranose mutase
Synonyms:Not Available
Gene Name:glf
Enzyme Class:
Biological Properties
General Function:Involved in nucleotide binding
Specific Function:Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Amino sugar and nucleotide sugar metabolism ec00520
  • Galactose metabolism ec00052
  • Lipopolysaccharide biosynthesis ec00540
SMPDB Reactions:
1.0Thumb ↔ 1.0Thumb
1.0UDP-α-D-galactose ↔ 1.0UDP-D-Galacto-1,4-furanose
ReactionCard
EcoCyc Reactions:
1.0Thumb → 1.0Thumb
1.0Uridine diphosphategalactose → 1.0UDP-D-Galacto-1,4-furanose
ReactionCard
1.0Thumb ↔ 1.0Thumb
1.0Uridine diphosphategalactose ↔ 1.0UDP-D-Galacto-1,4-furanose
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB04165UDP-D-Galacto-1,4-furanoseMetaboCard
ECMDB24224UDP-α-D-galactoseMetaboCard
ECMDB00302Uridine diphosphategalactoseMetaboCard
GO Classification:
Function
adenyl nucleotide binding
binding
catalytic activity
FAD or FADH2 binding
intramolecular transferase activity
isomerase activity
nucleoside binding
oxidoreductase activity
purine nucleoside binding
UDP-galactopyranose mutase activity
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b2036
Gene OrientationCounterclockwise
Centisome Percentage:45.37
Left Sequence End2105250
Right Sequence End2106353
Gene Sequence:
>1104 bp
ATGAGTGACAGCCAGACGCTGGTGGTAAAACTCGGCACCAGTGTGCTAACAGGCGGATCG
CGCCGTCTGAACCGTGCCCATATCGTTGAACTTGTTCGCCAGTGCGCGCAGTTACATGCC
GCCGGGCATCGGATTGTTATTGTGACGTCGGGCGCGATCGCCGCCGGACGTGAGCACCTG
GGTTACCCGGAACTGCCAGCGACCATCGCCTCGAAACAACTGCTGGCGGCGGTAGGGCAG
AGTCGACTGATTCAACTGTGGGAACAGCTGTTTTCGATTTATGGCATTCACGTCGGGCAA
ATGCTGCTGACCCGTGCTGATATGGAAGACCGTGAACGCTTCCTGAACGCCCGCGACACC
CTGCGAGCGTTGCTCGATAACAATATCGTTCCGGTAATCAATGAGAACGATGCTGTCGCT
ACGGCAGAGATTAAGGTCGGCGATAACGATAACCTTTCTGCGCTGGCGGCGATTCTTGCG
GGTGCCGATAAACTGTTGCTGCTGACCGATCAAAAAGGTTTGTATACCGCTGACCCGCGC
AGCAATCCGCAGGCAGAACTGATTAAAGATGTTTACGGCATTGATGACGCACTGCGCGCG
ATTGCCGGTGACAGCGTTTCAGGCCTCGGAACTGGCGGCATGAGTACCAAATTGCAGGCC
GCTGACGTGGCTTGCCGTGCGGGTATCGACACCATTATTGCCGCGGGCAGCAAGCCGGGC
GTTATTGGTGATGTGATGGAAGGCATTTCCGTCGGTACGCTGTTCCATGCCCAGGCGACT
CCGCTTGAAAACCGTAAACGCTGGATTTTCGGTGCGCCGCCGGCGGGTGAAATCACGGTA
GATGAAGGGGCAACTGCCGCCATTCTGGAACGCGGCAGCTCCCTGTTGCCGAAAGGCATT
AAAAGCGTGACTGGCAATTTCTCGCGTGGTGAAGTCATCCGCATTTGCAACCTCGAAGGC
CGCGATATCGCCCACGGCGTCAGTCGTTACAACAGCGATGCATTACGCCGTATTGCCGGA
CACCACTCGCAAGAAATTGATGCAATACTGGGATATGAATACGGCCCGGTTGCCGTTCAC
CGTGATGACATGATTACCCGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:367
Protein Molecular Weight:42966
Protein Theoretical pI:7
PDB File:1I8T
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>UDP-galactopyranose mutase
MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFHT
NDKYIWDYVNDLVEFNRFTNSPLAIYKDKLFNLPFNMNTFHQMWGVKDPQEAQNIINAQK
KKYGDKVPENLEEQAISLVGEDLYQALIKGYTEKQWGRSAKELPAFIIKRIPVRFTFDNN
YFSDRYQGIPVGGYTKLIEKMLEGVDVKLGIDFLKDKDSLASKAHRIIYTGPIDQYFDYR
FGALEYRSLKFETERHEFPNFQGNAVINFTDANVPYTRIIEHKHFDYVETKHTVVTKEYP
LEWKVGDEPYYPVNDNKNMELFKKYRELASREDKVIFGGRLAEYKYYDMHQVISAALYQV
KNIMSTD
References
External Links:
ResourceLink
Uniprot ID:P37747
Uniprot Name:GLF_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674394
PDB ID:1I8T
Ecogene ID:EG11981
Ecocyc:EG11981
ColiBase:b2036
Kegg Gene:b2036
EchoBASE ID:EB1924
CCDB:GLF_ECOLI
BacMap:16129976
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Nassau, P. M., Martin, S. L., Brown, R. E., Weston, A., Monsey, D., McNeil, M. R., Duncan, K. (1996). "Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase." J Bacteriol 178:1047-1052. Pubmed: 8576037
  • Stevenson, G., Neal, B., Liu, D., Hobbs, M., Packer, N. H., Batley, M., Redmond, J. W., Lindquist, L., Reeves, P. (1994). "Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster." J Bacteriol 176:4144-4156. Pubmed: 7517391
  • Yao, Z., Valvano, M. A. (1994). "Genetic analysis of the O-specific lipopolysaccharide biosynthesis region (rfb) of Escherichia coli K-12 W3110: identification of genes that confer group 6 specificity to Shigella flexneri serotypes Y and 4a." J Bacteriol 176:4133-4143. Pubmed: 7517390