Ribose-5-phosphate isomerase B (P37351)

Identification
Name:Ribose-5-phosphate isomerase B
Synonyms:
  • Phosphoriboisomerase B
Gene Name:rpiB
Enzyme Class:
Biological Properties
General Function:Involved in carbohydrate metabolic process
Specific Function:In addition to its activity on D-ribose 5-phosphate it probably also has activity on D-allose 6-phosphate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Carbon fixation in photosynthetic organisms ec00710
  • Fructose and mannose metabolism ec00051
  • Metabolic pathways eco01100
  • Microbial metabolism in diverse environments ec01120
  • Pentose phosphate pathway ec00030
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Ribose-5-phosphate ↔ 1.0D-Ribulose 5-phosphate
ReactionCard
1.0Thumb ↔ 1.0D-Ribulose 5-phosphate
1.0D-Ribose-5-phosphate ↔ 1.0D-Ribulose 5-phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Ribulose 5-phosphate ↔ 1.0D-Ribose-5-phosphate
ReactionCard
1.0aldehydo-D-allose 6-phosphate+1.0Thumb → 1.0D-allulose 6-phosphate+1.0Thumb
1.0aldehydo-D-allose 6-phosphate + 1.0aldehydo-D-allose 6-phosphate → 1.0D-allulose 6-phosphate + 1.0D-Allulose-6-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Ribose-5-phosphate ↔ 1.0D-Ribulose 5-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb
1.0D-Allose 6-phosphate ↔ 1.0D-Allulose-6-phosphate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0D-Allose 6-phosphate → 1.0D-Allulose-6-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB24209aldehydo-D-allose 6-phosphateMetaboCard
ECMDB21197D-Allose 6-phosphateMetaboCard
ECMDB20540D-Allulose-6-phosphateMetaboCard
ECMDB02033D-Ribose-5-phosphateMetaboCard
ECMDB04148D-Ribulose 5-phosphateMetaboCard
GO Classification:
Function
catalytic activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
isomerase activity
ribose-5-phosphate isomerase activity
Process
alcohol metabolic process
carbohydrate metabolic process
glucose catabolic process
glucose metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
pentose-phosphate shunt
primary metabolic process
small molecule metabolic process
Gene Properties
Blattner:b4090
Gene OrientationClockwise
Centisome Percentage:92.92
Left Sequence End4311373
Right Sequence End4311822
Gene Sequence:
>450 bp
ATGTCTGAATCTGTACAGAGCAATAGCGCCGTCCTGGTGCACTTCACGCTAAAACTCGAC
GATGGCACCACCGCCGAGTCTACCCGCAACAACGGTAAACCGGCGCTGTTCCGCCTGGGT
GATGCTTCTCTTTCTGAAGGGCTGGAGCAACACCTGTTGGGGCTGAAAGTGGGCGATAAA
ACCACCTTCTCGTTGGAGCCAGATGCGGCGTTTGGCGTGCCGTCACCGGACCTGATTCAG
TACTTCTCCCGCCGTGAATTTATGGATGCAGGCGAGCCAGAAATTGGCGCAATCATGCTT
TTTACCGCAATGGATGGCAGTGAGATGCCTGGCGTGATCCGCGAAATTAACGGCGACTCC
ATTACCGTTGATTTCAACCATCCGCTGGCCGGGCAGACCGTTCATTTTGATATTGAAGTG
CTGGAAATCGATCCGGCACTGGAGGCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:149
Protein Molecular Weight:16073
Protein Theoretical pI:7
PDB File:1NN4
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ribose-5-phosphate isomerase B
MKKIAFGCDHVGFILKHEIVAHLVERGVEVIDKGTWSSERTDYPHYASQVALAVAGGEVD
GGILICGTGVGISIAANKFAGIRAVVCSEPYSAQLSRQHNDTNVLAFGSRVVGLELAKMI
VDAWLGAQYEGGRHQQRVEAITAIEQRRN
References
External Links:
ResourceLink
Uniprot ID:P37351
Uniprot Name:RPIB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21321910
PDB ID:1NN4
Ecogene ID:EG11827
Ecocyc:EG11827
ColiBase:b4090
Kegg Gene:b4090
EchoBASE ID:EB1774
CCDB:RPIB_ECOLI
BacMap:16131916
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Borodovsky, M., Rudd, K. E., Koonin, E. V. (1994). "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Nucleic Acids Res 22:4756-4767. Pubmed: 7984428
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kim, C., Song, S., Park, C. (1997). "The D-allose operon of Escherichia coli K-12." J Bacteriol 179:7631-7637. Pubmed: 9401019
  • Makino, K., Kim, S. K., Shinagawa, H., Amemura, M., Nakata, A. (1991). "Molecular analysis of the cryptic and functional phn operons for phosphonate use in Escherichia coli K-12." J Bacteriol 173:2665-2672. Pubmed: 1840580
  • Sorensen, K. I., Hove-Jensen, B. (1996). "Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression." J Bacteriol 178:1003-1011. Pubmed: 8576032