HTH-type transcriptional regulator treR (P36673)

Identification
Name:HTH-type transcriptional regulator treR
Synonyms:
  • Trehalose operon repressor
Gene Name:treR
Enzyme Class:Not Available
Biological Properties
General Function:Involved in DNA binding
Specific Function:Repressor of the treBC operon. Binds trehalose 6- phosphate as an inducer
Cellular Location:Cytoplasmic
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Component
cell part
intracellular
Function
binding
DNA binding
nucleic acid binding
sequence-specific DNA binding transcription factor activity
specific transcriptional repressor activity
transcription regulator activity
transcription repressor activity
Process
biological regulation
carbohydrate metabolic process
disaccharide metabolic process
metabolic process
negative regulation of gene expression
negative regulation of transcription
oligosaccharide metabolic process
primary metabolic process
regulation of biological process
regulation of gene expression
regulation of macromolecule metabolic process
regulation of metabolic process
regulation of transcription
regulation of transcription, DNA-dependent
trehalose metabolic process
Gene Properties
Blattner:b4241
Gene OrientationCounterclockwise
Centisome Percentage:96.22
Left Sequence End4464322
Right Sequence End4465269
Gene Sequence:
>948 bp
ATGAGACAAACTCTTTGCGACGGATATCTGGTCATTTTTGCGTTAGCACAGGCCGTGATT
CTGCTGATGCTAACCCCACTTTTTACGGGTATTTCCCGGCAGATACGCGCGCGTATGCAC
TCCCGCCGCGGGCCGGGGATCTGGCAGGATTATCGCGATATCCACAAACTGTTTAAACGC
CAGGAAGTTGCGCCGACATCTTCAGGTCTGATGTTCCGCCTGATGCCGTGGGTATTAATC
AGCAGCATGCTGGTGCTGGCGATGGCCTTACCACTGTTTATTACCGTTTCCCCTTTTGCG
GGCGGCGGCGATCTGATCACCCTTATCTATCTTCTTGCCCTGTTTCGTTTTTTCTTTGCT
CTTTCCGGGCTGGATACCGGAAGTCCGTTTGCGGGAGTCGGTGCCAGTCGCGAGTTGACG
CTCGGCATTCTGGTCGAACCAATGCTTATTCTCTCACTGCTGGTATTGGCGCTGATAGCA
GGTTCCACGCATATCGAGATGATCAGCAATACGCTGGCGATGGGCTGGAACTCGCCGCTA
ACCACCGTACTGGCGTTACTGGCCTGTGGTTTTGCCTGCTTCATTGAGATGGGAAAAATT
CCCTTTGATGTTGCTGAAGCAGAACAGGAATTACAGGAAGGCCCGCTGACCGAATATTCC
GGTGCCGGGCTGGCGCTAGCGAAATGGGGGCTGGGGCTGAAACAGGTCGTGATGGCATCA
CTGTTTGTGGCCCTGTTTCTGCCCTTTGGGCGCGCGCAAGAACTTTCTCTCGCCTGCCTG
CTGACTTCACTTGTCGTTACGCTGCTCAAGGTTTTGCTGATTTTTGTACTGGCCTCAATC
GCAGAAAACACGCTGGCACGCGGGCGTTTTTTACTCATTCACCATGTGACCTGGCTTGGC
TTCAGCCTTGCTGCGCTTGCATGGGTCTTCTGGTTAACCGGTCTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:315
Protein Molecular Weight:34530
Protein Theoretical pI:8
PDB File:1BYK
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>HTH-type transcriptional regulator treR
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQLTRERVEAVMNQHGFSPSRSARAMRGQ
SDKVVAIIVTRLDSLSENLAVQTMLPAFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNID
GVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDEGAIKILMQRLYDQGHRNISY
LGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYAEAGRQAACQLIAQVT
GRSEPQQIIIPATLS
References
External Links:
ResourceLink
Uniprot ID:P36673
Uniprot Name:TRER_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675421
PDB ID:1BYK
Ecogene ID:EG12202
Ecocyc:EG12202
ColiBase:b4241
Kegg Gene:b4241
EchoBASE ID:EB2118
CCDB:TRER_ECOLI
BacMap:16132063
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hars, U., Horlacher, R., Boos, W., Welte, W., Diederichs, K. (1998). "Crystal structure of the effector-binding domain of the trehalose-repressor of Escherichia coli, a member of the LacI family, in its complexes with inducer trehalose-6-phosphate and noninducer trehalose." Protein Sci 7:2511-2521. Pubmed: 9865945
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Horlacher, R., Boos, W. (1997). "Characterization of TreR, the major regulator of the Escherichia coli trehalose system." J Biol Chem 272:13026-13032. Pubmed: 9148912
  • Klein, W., Horlacher, R., Boos, W. (1995). "Molecular analysis of treB encoding the Escherichia coli enzyme II specific for trehalose." J Bacteriol 177:4043-4052. Pubmed: 7608078