Identification
Name:Multidrug resistance protein MdtO
Synonyms:Not Available
Gene Name:mdtO
Enzyme Class:Not Available
Biological Properties
General Function:sulfathiazole transport
Specific Function:Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
integral component of membrane
plasma membrane
response to antibiotic
sulfathiazole transmembrane transport
sulfathiazole transmembrane transporter activity
sulfathiazole transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>2052
atgagcgcgctcaactccctgccattaccggtggtcaggctgctggcgttctttcatgaa
gagttaagcgagcggcgaccaggtcgcgtgccgcagaccgtgcaactctgggtaggctgc
ctgctggtgattctgatctcgatgacctttgagatcccttttgtggcgttatcgctggca
gtgctgttttacggtattcagtcgaacgcgttttacaccaaatttgtcgcgatcttgttt
gtggttgccacggtgctggagatcggcagcctgtttttgatctacaaatggtcatacggc
gaaccgttgatccgattgatcatcgccggaccgatcctgatgggctgcatgtttttgatg
cgcacccatcgcttggggctggtctttttcgccgtcgccattgtcgctatttacgggcaa
accttccccgccatgctcgactatccggaagtggtcgtgcgcttaacgctgtggtgtatc
gttgttggcctctatccaaccttgctgatgacgttaatcggcgtgctgtggtttcccagt
cgtgccatttcgcaaatgcatcaggcgcttaatgatcggcttgatgatgccattagtcac
ctgacagacagcctcgcaccgctacccgaaacgcggattgaaagagaggcgctggcgcta
caaaaactcaatgtcttttgcctcgcggacgatgccaactggcgaactcaaaacgcatgg
tggcaaagctgcgtggcaacggtaacctacatttactcgacgctgaatcgctacgatccc
acctcttttgctgattctcaggcaattattgaattccgacaaaaattagcttcagaaatc
aacaagctgcagcatgccgttgctgaaggtcagtgctggcaaagcgactggcggatcagt
gaaagtgaagcgatggcggcacgggaatgtaacctggagaatatctgccagacgttgtta
caactgggtcagatggacccgaatacgccgccaacgcccgcagccaaaccgccatcaatg
gccgccgatgcttttaccaatccagactatatgcgctacgcggtaaaaacgctgctcgcc
tgtttgatctgttacaccttttacagcggcgtggactgggaaggcattcacacctgtatg
ctgacatgcgtgatcgtcgctaacccaaatgtcggttcgtcgtaccagaagatggtgctg
cgttttggcggggccttttgcggcgcgattctggcgctgttattcacgctactggtcatg
ccctggctggacaatattgtcgaattgctgtttgtgctggcaccgattttcctgttgggc
gcatggattgccaccagctctgaacgctcttcttatatcggcacacagatggtggtcacc
ttcgcgctcgccacgctcgaaaacgtttttggcccagtgtacgacctggtggaaattcgc
gatcgcgccctgggtatcatcattggtaccgtggtgtccgcggtgatttacacctttgtc
tggcctgaaagtgaagcgcgcacactgccgcaaaaactggctggcacgctgggtatgtta
agtaaagtaatgcggatcccacgccagcaggaagtcacggctctgcgcacttatctgcaa
attcgtatcggtctgcatgcggcgtttaatgcctgtgaagagatgtgccaacgcgtggcg
ctggagcgtcaactggacagcgaagaacgcgcattactgattgaacgttcgcaaacggtt
attcgtcagggccgcgatcttcttcacgcctgggatgccacctggaactcggcgcaggcg
ctggataacgcactacagccggacagagcaggtcagtttgccgacgccctggagaaatac
gctgccggtctggcaaccgcactcagccgttctcctcaaataacgcttgaagagacaccc
gcctctcaggccatcctgcccaccttattaaaacaggagcaacacgtctgccagcttttc
gcccgcttgccagactggacagccccggcattaacgcccgccacggaacaggcacaagga
gccacgcaatga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:683
Protein Molecular Weight:76149
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:
  • 43-63
  • 75-95
  • 100-120
  • 125-145
  • 158-178
  • 402-422
  • 426-446
  • 457-477
  • 483-503
Protein Sequence:
>Multidrug resistance protein MdtO
MSALNSLPLPVVRLLAFFHEELSERRPGRVPQTVQLWVGCLLVILISMTFEIPFVALSLA
VLFYGIQSNAFYTKFVAILFVVATVLEIGSLFLIYKWSYGEPLIRLIIAGPILMGCMFLM
RTHRLGLVFFAVAIVAIYGQTFPAMLDYPEVVVRLTLWCIVVGLYPTLLMTLIGVLWFPS
RAISQMHQALNDRLDDAISHLTDSLAPLPETRIEREALALQKLNVFCLADDANWRTQNAW
WQSCVATVTYIYSTLNRYDPTSFADSQAIIEFRQKLASEINKLQHAVAEGQCWQSDWRIS
ESEAMAARECNLENICQTLLQLGQMDPNTPPTPAAKPPSMAADAFTNPDYMRYAVKTLLA
CLICYTFYSGVDWEGIHTCMLTCVIVANPNVGSSYQKMVLRFGGAFCGAILALLFTLLVM
PWLDNIVELLFVLAPIFLLGAWIATSSERSSYIGTQMVVTFALATLENVFGPVYDLVEIR
DRALGIIIGTVVSAVIYTFVWPESEARTLPQKLAGTLGMLSKVMRIPRQQEVTALRTYLQ
IRIGLHAAFNACEEMCQRVALERQLDSEERALLIERSQTVIRQGRDLLHAWDATWNSAQA
LDNALQPDRAGQFADALEKYAAGLATALSRSPQITLEETPASQAILPTLLKQEQHVCQLF
ARLPDWTAPALTPATEQAQGATQ
References
External Links:
ResourceLink
Uniprot ID:P32715
Uniprot Name:MDTO_ECOLI
CCDB:MDTO_ECOLI
General Reference:Not Available