| Identification |
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| Name: | Fructose-like phosphotransferase enzyme IIA component |
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| Synonyms: | - PTS system fructose-like EIIA component
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| Gene Name: | frvA |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Involved in transporter activity |
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| Specific Function: | The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane |
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| Cellular Location: | Cytoplasm (Probable) |
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| SMPDB Pathways: | |
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| KEGG Pathways: | - Amino sugar and nucleotide sugar metabolism ec00520
- Ascorbate and aldarate metabolism ec00053
- Fructose and mannose metabolism ec00051
- Galactose metabolism ec00052
- Glycolysis / Gluconeogenesis ec00010
- Metabolic pathways eco01100
- Microbial metabolism in diverse environments ec01120
- Pentose phosphate pathway ec00030
- Starch and sucrose metabolism ec00500
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| KEGG Reactions: | |
1.0Protein N(pi)-phospho-L-histidine | + | 1.0Sugar | ↔ | 1.0Protein histidine | + | 1.0 |
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| Complex Reactions: | |
1.0Protein EIIA N(pi)-phospho-L-histidine | + | 1.0protein EIIB | → | 1.0protein EIIA | + | 1.0protein EIIB N(pi)-phospho-L-histidine/cysteine |
| 1.0Protein EIIA N(pi)-phospho-L-histidine + 1.0protein EIIB → 1.0protein EIIA + 1.0protein EIIB N(pi)-phospho-L-histidine/cysteine ReactionCard |
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| Metabolites: | |
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| GO Classification: | | Component |
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| cell part | | integral to membrane | | intrinsic to membrane | | membrane part | | Function |
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| carbohydrate transmembrane transporter activity | | cation transmembrane transporter activity | | cation:sugar symporter activity | | ion transmembrane transporter activity | | protein-N(PI)-phosphohistidine-sugar phosphotransferase activity | | solute:cation symporter activity | | substrate-specific transmembrane transporter activity | | sugar:hydrogen symporter activity | | transmembrane transporter activity | | transporter activity | | Process |
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| carbohydrate transport | | establishment of localization | | phosphoenolpyruvate-dependent sugar phosphotransferase system | | transport |
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| Gene Properties |
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| Blattner: | b3900 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 88.16 |
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| Left Sequence End | 4090400 |
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| Right Sequence End | 4090846 |
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| Gene Sequence: | >447 bp
ATGAGCGATGTACCTTTCTGGCAAAGTAAAACCCTGGACGAAATGAGCGATGCGGAATGG
GAGTCGTTGTGTGATGGTTGCGGTCAGTGTTGCCTGCATAAACTGATGGATGAAGACACC
GACGAAATCTACTTCACTAACGTCGCCTGTCGCCAGCTCAATATTAAAACCTGTCAATGT
CGGAACTACGAACGTCGTTTCGAGTTTGAACCCGACTGCATTAAATTAACCCGTGAAAAT
CTGCCAACATTCGAATGGCTGCCAATGACCTGCGCTTATCGTTTGCTGGCGGAAGGTAAA
GATTTACCTGCGTGGCATCCGCTACTTACTGGTTCGAAAGCGGCAATGCATGGTGAACGT
ATCTCTGTGCGTCATATCGCAGTGAAAGAATCAGAAGTGATTGACTGGCAGGATCATATC
TTAAATAAACCTGACTGGGCGCAGTGA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 148 |
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| Protein Molecular Weight: | 16093 |
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| Protein Theoretical pI: | 7 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Fructose-like phosphotransferase enzyme IIA component
MAALTASCIDLNIQGNGAYSVLKQLATIALQNGFITDSHQFLQTLLLREKMHSTGFGSGV
AVPHGKSACVKQPFVLFARKAQAIDWKASDGEDVNCWICLGVPQSGEEDQVKIIGTLCRK
IIHKEFIHQLQQGDTDQVLALLNQTLSS |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Moralejo, P., Egan, S. M., Hidalgo, E., Aguilar, J. (1993). "Sequencing and characterization of a gene cluster encoding the enzymes for L-rhamnose metabolism in Escherichia coli." J Bacteriol 175:5585-5594. Pubmed: 8396120
- Plunkett, G. 3rd, Burland, V., Daniels, D. L., Blattner, F. R. (1993). "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Nucleic Acids Res 21:3391-3398. Pubmed: 8346018
- Reizer, J., Michotey, V., Reizer, A., Saier, M. H. Jr (1994). "Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems." Protein Sci 3:440-450. Pubmed: 8019415
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