Phosphoglucosamine mutase (P31120)

Identification
Name:Phosphoglucosamine mutase
Synonyms:Not Available
Gene Name:glmM
Enzyme Class:
Biological Properties
General Function:Involved in intramolecular transferase activity, phosphotransferases
Specific Function:Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Can also catalyze the formation of glucose-6-P from glucose-1-P, although at a 1400-fold lower rate
Cellular Location:Not Available
SMPDB Pathways:
  • 1,6-anhydro-<i>N</i>-acetylmuramic acid recycling PW002064
  • Amino sugar and nucleotide sugar metabolism I PW000886
  • Lipopolysaccharide biosynthesis PW000831
  • O-antigen building blocks biosynthesis PW002089
  • lipopolysaccharide biosynthesis II PW001905
  • lipopolysaccharide biosynthesis III PW002059
  • peptidoglycan biosynthesis I PW000906
  • peptidoglycan biosynthesis I 2 PW002062
KEGG Pathways:
KEGG Reactions:
1.0alpha-D-Glucosamine 1-phosphate+1.0Thumb ↔ 1.0Thumb
1.0alpha-D-Glucosamine 1-phosphate + 1.0alpha-D-Glucosamine 1-phosphate ↔ 1.0Glucosamine 6-phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb ↔ 1.0Glucosamine-1P+1.0Thumb
1.0Glucosamine 6-phosphate ↔ 1.0Glucosamine-1P + 1.0Glucosamine-1P
ReactionCard
1.0D-glucosamine 6-phosphate ↔ 1.0Thumb
1.0D-glucosamine 6-phosphate ↔ 1.0Glucosamine-1P
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Glucosamine-1P ↔ 1.0Glucosamine 6-phosphate
ReactionCard
Complex Reactions:
1.0Thumb ↔ 1.0Thumb
1.0N-Acetyl-glucosamine 1-phosphate ↔ 1.0Glucosamine 6-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21662alpha-D-Glucosamine 1-phosphateMetaboCard
ECMDB03514alpha-D-Glucose 1,6-bisphosphateMetaboCard
ECMDB21663beta-D-Fructose 2-phosphateMetaboCard
ECMDB01254Glucosamine 6-phosphateMetaboCard
ECMDB01109Glucosamine-1PMetaboCard
ECMDB01367N-Acetyl-glucosamine 1-phosphateMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
ion binding
isomerase activity
magnesium ion binding
metal ion binding
phosphoglucosamine mutase activity
Process
carbohydrate metabolic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b3176
Gene OrientationCounterclockwise
Centisome Percentage:71.57
Left Sequence End3320755
Right Sequence End3322092
Gene Sequence:
>1338 bp
ATGCACTCTCAAATCTGGGTTGTGAGCACGCTGCTTATCAGCATCGTGTTAATTGTACTG
ACCATCGTGAAGTTCAAATTCCACCCGTTTCTGGCGCTGTTGCTGGCCAGCTTCTTCGTG
GGAACGATGATGGGCATGGGGCCACTGGATATGGTAAATGCTATTGAAAGTGGAATTGGC
GGAACGCTGGGGTTCCTCGCAGCGGTTATCGGCCTTGGCACGATACTGGGAAAAATGATG
GAAGTATCCGGGGCCGCAGAAAGAATTGGTCTGACACTTCAACGCTGCCGCTGGCTTTCA
GTTGATGTCATTATGGTGCTGGTTGGCCTGATTTGTGGCATCACGCTGTTTGTTGAAGTG
GGCGTCGTGCTATTGATTCCTCTGGCTTTTTCAATTGCCAAAAAAACCAATACCTCATTA
TTAAAGCTTGCCATTCCGCTATGTACCGCATTGATGGCAGTGCACTGCGTGGTTCCTCCA
CATCCGGCTGCTTTATATGTTGCCAATAAGCTGGGCGCAGATATCGGTTCGGTGATCGTC
TACGGTTTGCTGGTTGGGCTGATGGCATCACTGATCGGTGGCCCACTTTTCCTTAAATTT
CTGGGTCAACGACTGCCCTTTAAACCTGTACCCACAGAGTTTGCAGATCTCAAAGTTCGC
GATGAAAAAACACTACCGTCATTAGGCGCAACGTTATTCACCATACTGCTACCCATTGCG
CTGATGTTGGTTAAAACGATTGCCGAATTGAATATGGCGCGTGAGAGTGGTTTGTATATC
TTGGTTGAGTTTATTGGCAACCCTATCACTGCCATGTTTATCGCCGTGTTTGTCGCCTAT
TATGTGTTGGGTATACGCCAGCATATGAGCATGGGGACGATGCTCACACATACGGAAAAT
GGCTTCGGTTCTATTGCTAATATTTTGCTGATTATCGGGGCCGGAGGCGCATTCAACGCC
ATTTTAAAAAGCAGCAGTCTCGCTGATACGCTGGCAGTTATTCTCTCCAATATGCATATG
CACCCGATTCTTCTGGCCTGGTTAGTGGCTCTTATTCTGCATGCGGCAGTGGGCTCCGCT
ACCGTGGCAATGATGGGGGCAACGGCAATTGTTGCACCCATGCTGCCGCTGTATCCCGAC
ATCAGCCCGGAAATTATTGCGATTGCTATCGGTTCAGGTGCAATTGGCTGCACTATCGTT
ACGGACTCGCTTTTCTGGCTAGTGAAGCAATATTGCGGCGCTACGCTCAATGAAACATTT
AAATACTATACGACAGCGACATTTATCGCTTCAGTCGTCGCTCTGGCGGGCACATTCCTG
CTGTCATTTATCATCTAA
Protein Properties
Pfam Domain Function:
Protein Residues:445
Protein Molecular Weight:47543
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Phosphoglucosamine mutase
MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLES
ALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTK
LPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVD
CANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAF
DGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIP
FARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLH
DLCSGMKMFPQILVNVRYTAGSGDPLEHESVKAVTAEVEAALGNRGRVLLRKSGTEPLIR
VMVEGEDEAQVTEFAHRIADAVKAV
References
External Links:
ResourceLink
Uniprot ID:P31120
Uniprot Name:GLMM_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1799764
Ecogene ID:EG11553
Ecocyc:EG11553
ColiBase:b3176
Kegg Gene:b3176
EchoBASE ID:EB1514
CCDB:GLMM_ECOLI
BacMap:16131066
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Dallas, W. S., Dev, I. K., Ray, P. H. (1993). "The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome." J Bacteriol 175:7743-7744. Pubmed: 8244950
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Jolly, L., Ferrari, P., Blanot, D., Van Heijenoort, J., Fassy, F., Mengin-Lecreulx, D. (1999). "Reaction mechanism of phosphoglucosamine mutase from Escherichia coli." Eur J Biochem 262:202-210. Pubmed: 10231382
  • Jolly, L., Pompeo, F., van Heijenoort, J., Fassy, F., Mengin-Lecreulx, D. (2000). "Autophosphorylation of phosphoglucosamine mutase from Escherichia coli." J Bacteriol 182:1280-1285. Pubmed: 10671448
  • Mengin-Lecreulx, D., van Heijenoort, J. (1996). "Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli." J Biol Chem 271:32-39. Pubmed: 8550580