Identification
Name:Membrane protein insertase YidC
Synonyms:Not Available
Gene Name:yidC
Enzyme Class:Not Available
Biological Properties
General Function:protein insertion into membrane
Specific Function:Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
Metabolites:
ECMDB IDNameView
GO Classification:
Function
integral component of membrane
integral component of plasma membrane
membrane insertase activity
plasma membrane
protein complex assembly
protein folding
protein homooligomerization
protein insertion into membrane
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1647
atggattcgcaacgcaatcttttagtcatcgctttgctgttcgtgtctttcatgatctgg
caagcctgggagcaggataaaaacccgcaacctcaggcccaacagaccacgcagacaacg
accaccgcagcgggtagcgccgccgaccagggcgtaccggccagtggccaggggaaactg
atctcggttaagaccgacgtgcttgatctgaccatcaacacccgtggtggtgatgttgag
caagctctgctgcctgcttacccgaaagagctgaactctacccagccgttccagctgttg
gaaacttcaccgcagtttatttatcaggcacagagcggtctgaccggtcgtgatggcccg
gataacccggctaacggcccgcgtccgctgtataacgttgaaaaagacgcttatgtgctg
gctgaaggtcaaaacgaactgcaggtgccgatgacgtataccgacgcggcaggcaacacg
tttaccaaaacgtttgtcctgaaacgtggtgattacgctgtcaacgtcaactacaacgtg
cagaacgctggcgagaaaccgctggaaatctcctcgtttggtcagttgaagcaatccatc
actctgccaccgcatctcgataccggaagcagcaacttcgcactgcacaccttccgtggc
gcggcgtactccacgcctgacgagaagtatgagaaatacaagttcgataccattgccgat
aacgaaaacctgaacatctcttcgaaaggtggttgggtggcgatgctgcaacagtatttc
gcgacggcgtggatcccgcataacgacggtaccaacaacttctataccgctaatctgggt
aacggcatcgccgctatcggctataaatctcagccggtactggttcagcctggtcagact
ggcgcgatgaacagcaccctgtgggttggcccggaaatccaggacaaaatggcagctgtt
gctccgcacctggatctgaccgttgattacggttggttgtggttcatctctcagccgctg
ttcaaactgctgaaatggatccatagctttgtgggtaactggggcttctccattatcatc
atcacctttatcgttcgtggcatcatgtacccgctgaccaaagcgcagtacacctccatg
gcgaagatgcgtatgttgcagccgaagattcaggcaatgcgtgagcgtctgggcgatgac
aaacagcgtatcagccaggaaatgatggcgctgtacaaagctgagaaggttaacccgctg
ggcggctgcttcccgctgctgatccagatgccaatcttcctggcgttgtactacatgctg
atgggttccgttgaactgcgtcaggcaccgtttgcactgtggatccacgacctgtcggca
caggacccgtactacatcctgccgatcctgatgggcgtaacgatgttcttcattcagaag
atgtcgccgaccacagtgaccgacccgatgcagcagaagatcatgacctttatgccggtc
atcttcaccgtgttcttcctgtggttcccgtcaggtctggtgctgtactatatcgtcagc
aacctggtaaccattattcagcagcagctgatttaccgtggtctggaaaaacgtggcctg
catagccgcgagaagaaaaaatcctga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:548
Protein Molecular Weight:61525
Protein Theoretical pI:Not Available
PDB File:3BLC
Signaling Regions:Not Available
Transmembrane Regions:
  • 6-23
  • 343-370
  • 417-446
  • 464-481
  • 494-509
  • 513-535
Protein Sequence:
>Membrane protein insertase YidC
MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQAQQTTQTTTTAAGSAADQGVPASGQGKL
ISVKTDVLDLTINTRGGDVEQALLPAYPKELNSTQPFQLLETSPQFIYQAQSGLTGRDGP
DNPANGPRPLYNVEKDAYVLAEGQNELQVPMTYTDAAGNTFTKTFVLKRGDYAVNVNYNV
QNAGEKPLEISSFGQLKQSITLPPHLDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIAD
NENLNISSKGGWVAMLQQYFATAWIPHNDGTNNFYTANLGNGIAAIGYKSQPVLVQPGQT
GAMNSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIII
ITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPL
GGCFPLLIQMPIFLALYYMLMGSVELRQAPFALWIHDLSAQDPYYILPILMGVTMFFIQK
MSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGL
HSREKKKS
References
External Links:
ResourceLink
Uniprot ID:P25714
Uniprot Name:YIDC_ECOLI
PDB ID:3BLC
CCDB:YIDC_ECOLI
General Reference:Not Available