| Identification |
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| Name: | Membrane protein insertase YidC |
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| Synonyms: | Not Available |
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| Gene Name: | yidC |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | protein insertion into membrane |
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| Specific Function: | Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| integral component of membrane | | integral component of plasma membrane | | membrane insertase activity | | plasma membrane | | protein complex assembly | | protein folding | | protein homooligomerization | | protein insertion into membrane |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1647
atggattcgcaacgcaatcttttagtcatcgctttgctgttcgtgtctttcatgatctgg
caagcctgggagcaggataaaaacccgcaacctcaggcccaacagaccacgcagacaacg
accaccgcagcgggtagcgccgccgaccagggcgtaccggccagtggccaggggaaactg
atctcggttaagaccgacgtgcttgatctgaccatcaacacccgtggtggtgatgttgag
caagctctgctgcctgcttacccgaaagagctgaactctacccagccgttccagctgttg
gaaacttcaccgcagtttatttatcaggcacagagcggtctgaccggtcgtgatggcccg
gataacccggctaacggcccgcgtccgctgtataacgttgaaaaagacgcttatgtgctg
gctgaaggtcaaaacgaactgcaggtgccgatgacgtataccgacgcggcaggcaacacg
tttaccaaaacgtttgtcctgaaacgtggtgattacgctgtcaacgtcaactacaacgtg
cagaacgctggcgagaaaccgctggaaatctcctcgtttggtcagttgaagcaatccatc
actctgccaccgcatctcgataccggaagcagcaacttcgcactgcacaccttccgtggc
gcggcgtactccacgcctgacgagaagtatgagaaatacaagttcgataccattgccgat
aacgaaaacctgaacatctcttcgaaaggtggttgggtggcgatgctgcaacagtatttc
gcgacggcgtggatcccgcataacgacggtaccaacaacttctataccgctaatctgggt
aacggcatcgccgctatcggctataaatctcagccggtactggttcagcctggtcagact
ggcgcgatgaacagcaccctgtgggttggcccggaaatccaggacaaaatggcagctgtt
gctccgcacctggatctgaccgttgattacggttggttgtggttcatctctcagccgctg
ttcaaactgctgaaatggatccatagctttgtgggtaactggggcttctccattatcatc
atcacctttatcgttcgtggcatcatgtacccgctgaccaaagcgcagtacacctccatg
gcgaagatgcgtatgttgcagccgaagattcaggcaatgcgtgagcgtctgggcgatgac
aaacagcgtatcagccaggaaatgatggcgctgtacaaagctgagaaggttaacccgctg
ggcggctgcttcccgctgctgatccagatgccaatcttcctggcgttgtactacatgctg
atgggttccgttgaactgcgtcaggcaccgtttgcactgtggatccacgacctgtcggca
caggacccgtactacatcctgccgatcctgatgggcgtaacgatgttcttcattcagaag
atgtcgccgaccacagtgaccgacccgatgcagcagaagatcatgacctttatgccggtc
atcttcaccgtgttcttcctgtggttcccgtcaggtctggtgctgtactatatcgtcagc
aacctggtaaccattattcagcagcagctgatttaccgtggtctggaaaaacgtggcctg
catagccgcgagaagaaaaaatcctga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 548 |
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| Protein Molecular Weight: | 61525 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 3BLC |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | - 6-23
- 343-370
- 417-446
- 464-481
- 494-509
- 513-535
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| Protein Sequence: | >Membrane protein insertase YidC
MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQAQQTTQTTTTAAGSAADQGVPASGQGKL
ISVKTDVLDLTINTRGGDVEQALLPAYPKELNSTQPFQLLETSPQFIYQAQSGLTGRDGP
DNPANGPRPLYNVEKDAYVLAEGQNELQVPMTYTDAAGNTFTKTFVLKRGDYAVNVNYNV
QNAGEKPLEISSFGQLKQSITLPPHLDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIAD
NENLNISSKGGWVAMLQQYFATAWIPHNDGTNNFYTANLGNGIAAIGYKSQPVLVQPGQT
GAMNSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIII
ITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPL
GGCFPLLIQMPIFLALYYMLMGSVELRQAPFALWIHDLSAQDPYYILPILMGVTMFFIQK
MSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGL
HSREKKKS |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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