Arylsulfatase (P25549)

Identification
Name:Arylsulfatase
Synonyms:
  • AS
  • Aryl-sulfate sulphohydrolase
Gene Name:aslA
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:A phenol sulfate + H(2)O = a phenol + sulfate
Cellular Location:Periplasm (Potential)
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0Estrone 3-sulfate+1.0Thumb ↔ 1.0Thumb+1.0Estrone
1.0Estrone 3-sulfate + 1.0Water ↔ 1.0Sulfate + 1.0Estrone
ReactionCard
1.0Sulfatide+1.0Thumb ↔ 1.0Galactosylceramide+1.0Thumb
1.0Sulfatide + 1.0Water ↔ 1.0Galactosylceramide + 1.0Sulfate
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Aryl sulfate + 1.0Water ↔ 1.0Phenol + 1.0Sulfate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0a phenol sulfate ↔ 1.0Thumb+1.0a phenol
1.0Water + 1.0a phenol sulfate ↔ 1.0Sulfate + 1.0a phenol
ReactionCard
Complex Reactions:
1.0A phenol sulfate+1.0Thumb → 1.0a phenol+1.0Thumb
1.0A phenol sulfate + 1.0Water → 1.0a phenol + 1.0Sulfate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01448SulfateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
sulfuric ester hydrolase activity
Process
metabolic process
Gene Properties
Blattner:b3801
Gene OrientationCounterclockwise
Centisome Percentage:85.83
Left Sequence End3982375
Right Sequence End3984030
Gene Sequence:
>1656 bp
ATGGAATTTTCGTTTTCACCCAAACGTCTTGTTGTTGCTGTCGCCGCCGCTCTTCCTCTC
ATGGCCAGCGCAGCAGATACCCCGTCAACTGCCACCGCACGCAAAGGCTTTGCCGGATAC
GATCACCCAAACCAGTATCTGGTTAAACCGGCGACCACTATTGCCGACAATATGATGCCA
GTAATGCAGCATCCGGCGCAGGATAAAGAAACCCAGCAGAAGCTGGCAGAACTTGAGAAA
AAAACCGGTAAGAAACCGAATGTGGTTGTTTTCTTGCTGGACGATGTGGGCTGGATGGAC
GTCGGTTTTAACGGTGGCGGCGTGGCGGTGGGTAACCCTACACCAGATATCGACGCCGTT
GCCAGCCAGGGGCTGATTTTAACTTCGGCGTATTCTCAACCAAGCTCTTCCCCAACCCGC
GCCACCATTCTCACCGGACAATACTCCATCCACCACGGCATTCTGATGCCGCCAATGTAC
GGGCAACCGGGCGGGCTGCAAGGGTTAACCACGCTGCCGCAGTTGCTGCACGATCAGGGC
TACGTCACTCAGGCCATCGGAAAATGGCATATGGGGGAAAACAAAGAGTCGCAGCCGCAG
AACGTTGGCTTTGATGATTTCCGTGGCTTTAACTCGGTGTCTGATATGTACACCGAATGG
CGCGACGTTCACGTCAATCCGGAAGTGGCCCTGAGTCCGGACCGTTCTGAATACATCAAG
CAATTACCGTTCAGCAAAGATGACGTTCATGCGGTGCGCGGCGGCGAACAACAGGCCATT
GCCGACATTACGCCGAAATATATGGAAGATCTGGATCAACGCTGGATGGACTATGGCGTT
AAGTTCCTCGACAAGATGGCGAAGAGCGATAAACCATTCTTCCTCTACTACGGCACTCGT
GGCTGCCACTTCGATAACTACCCAAATGCGAAATATGCGGGTAGCTCTCCGGCACGCACC
TCGTATGGCGACTGCATGGTGGAGATGAACGATGTGTTCGCTAATCTGTATAAAACACTG
GAGAAAAACGGTCAGCTTGATAACACGCTGATCGTCTTTACCTCCGATAACGGACCGGAA
GCCGAAGTACCGCCGCACGGACGCACCCCGTTCCGTGGTGCGAAAGGTTCGACCTGGGAA
GGCGGCGTTCGCGTACCGACTTTCGTTTACTGGAAAGGGATGATCCAACCGCGTAAATCT
GACGGTATTGTCGATCTGGCAGATCTCTTCCCTACCGCGCTGGATCTGGCAGGGCATCCT
GGAGCGAAAGTGGCGAATTTAGTGCCGAAAACCACCTTTATCGATGGTGTGGACCAGACA
TCCTTCTTCCTGGGAACAAATGGTCAGTCTAACCGTAAGGCCGAGCACTACTTCCTCAAC
GGTAAACTCGCTGCTGTGCGTATGGATGAGTTCAAGTATCACGTCCTGATTCAGCAACCT
TACGCTTATACCCAGAGCGGATATCAGGGTGGATTCACCGGCACAGTAATGCAAACGGCG
GGATCGTCGGTGTTTAACCTCTACACCGATCCGCAGGAAAGCGACTCCATCGGCGTGCGC
CATATTCCGATGGGTGTACCGCTACAGACCGAAATGCACGCGTATATGGAGATCCTGAAA
AAATATCCACCACGCGCGCAGATTAAATCTGACTAA
Protein Properties
Pfam Domain Function:
Protein Residues:551
Protein Molecular Weight:60717
Protein Theoretical pI:6
Signaling Regions:
  • 1-24
Transmembrane Regions:
  • None
Protein Sequence:
>Arylsulfatase
MEFSFSPKRLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMP
VMQHPAQDKETQQKLAELEKKTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAV
ASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMYGQPGGLQGLTTLPQLLHDQG
YVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIK
QLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMDYGVKFLDKMAKSDKPFFLYYGTR
GCHFDNYPNAKYAGSSPARTSYGDCMVEMNDVFANLYKTLEKNGQLDNTLIVFTSDNGPE
AEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKSDGIVDLADLFPTALDLAGHP
GAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILK
KYPPRAQIKSD
References
External Links:
ResourceLink
Uniprot ID:P25549
Uniprot Name:ASLA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85676250
Ecogene ID:EG10089
Ecocyc:EG10089
ColiBase:b3801
Kegg Gene:b3801
EchoBASE ID:EB0087
CCDB:ASLA_ECOLI
BacMap:16131653
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daniels, D. L., Plunkett, G. 3rd, Burland, V., Blattner, F. R. (1992). "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes." Science 257:771-778. Pubmed: 1379743
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553