Phosphomannomutase (P24175)

Identification
Name:Phosphomannomutase
Synonyms:
  • PMM
Gene Name:manB
Enzyme Class:
Biological Properties
General Function:Involved in intramolecular transferase activity, phosphotransferases
Specific Function:Involved in the biosynthesis of the capsular polysaccharide colanic acid
Cellular Location:Not Available
SMPDB Pathways:
  • Amino sugar and nucleotide sugar metabolism II PW000887
  • Mannose Metabolism PW000822
  • colanic acid building blocks biosynthesis PW000951
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Mannose 1-phosphate ↔ 1.0Mannose 6-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb
1.0Mannose 6-phosphate ↔ 1.0D-Mannose 1-phosphate
ReactionCard
SMPDB Reactions:
1.0α-D-mannose 6-phosphate → 1.0Thumb
1.0α-D-mannose 6-phosphate → 1.0D-Mannose 1-phosphate
ReactionCard
1.0α-D-mannose 6-phosphate ↔ 1.0α-D-mannose 1-phosphate
1.0α-D-mannose 6-phosphate ↔ 1.0α-D-mannose 1-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Mannose 1-phosphate ↔ 1.0Mannose 6-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01436D-Mannose 1-phosphateMetaboCard
ECMDB01078Mannose 6-phosphateMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
ion binding
isomerase activity
magnesium ion binding
metal ion binding
Process
carbohydrate metabolic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b2048
Gene OrientationCounterclockwise
Centisome Percentage:45.68
Left Sequence End2119633
Right Sequence End2121003
Gene Sequence:
>1371 bp
ATGAAAAAATTAACCTGCTTTAAAGCCTATGATATTCGCGGGAAATTAGGCGAAGAACTG
AATGAAGATATCGCCTGGCGCATTGGTCGCGCCTATGGCGAATTTCTCAAACCGAAAACC
ATTGTGTTAGGCGGTGATGTCCGCCTCACCAGCGAAACCTTAAAACTGGCGCTGGCGAAA
GGTTTACAGGATGCGGGCGTTGACGTGCTGGATATTGGTATGTCCGGCACCGAAGAGATC
TATTTCGCCACGTTCCATCTCGGCGTGGATGGCGGCATTGAAGTTACCGCCAGCCATAAT
CCGATGGATTATAACGGCATGAAGCTGGTTCGCGAGGGGGCTCGCCCGATCAGCGGAGAT
ACCGGACTGCGCGACGTCCAGCGTCTGGCTGAAGCCAACGACTTTCCTCCCGTCGATGAA
ACCAAACGCGGTCGCTATCAGCAAATCAACCTGCGTGACGCTTACGTTGATCACCTGTTC
GGTTATATCAATGTCAAAAACCTCACGCCGCTCAAGCTGGTGATCAACTCCGGGAACGGC
GCAGCGGGTCCGGTGGTGGACGCCATTGAAGCCCGCTTTAAAGCCCTCGGCGCGCCCGTG
GAATTAATCAAAGTGCACAACACGCCGGACGGCAATTTCCCCAACGGTATTCCTAACCCA
CTACTGCCGGAATGCCGCGACGACACCCGCAATGCGGTCATCAAACACGGCGCGGATATG
GGCATTGCTTTTGATGGCGATTTTGACCGCTGTTTCCTGTTTGACGAAAAAGGGCAGTTT
ATTGAGGGCTACTACATTGTCGGCCTGTTGGCAGAAGCATTCCTCGAAAAAAATCCCGGC
GCGAAGATCATCCACGATCCACGTCTCTCCTGGAACACCGTTGATGTGGTGACTGCCGCA
GGTGGCACGCCGGTAATGTCGAAAACCGGACACGCCTTTATTAAAGAACGTATGCGCAAG
GAAGACGCCATCTATGGTGGCGAAATGAGCGCCCACCATTACTTCCGTGATTTCGCTTAC
TGCGACAGCGGCATGATCCCGTGGCTGCTGGTCGCCGAACTGGTGTGCCTGAAAGATAAA
ACGCTGGGCGAACTGGTACGCGACCGGATGGCGGCGTTTCCGGCAAGCGGTGAGATCAAC
AGCAAACTGGCGCAACCCGTTGAGGCGATTAACCGCGTGGAACAGCATTTTAGCCGTGAG
GCGCTGGCGGTGGATCGCACCGATGGCATCAGCATGACCTTTGCCGACTGGCGCTTTAAC
CTGCGCACCTCCAATACCGAACCGGTGGTGCGCCTGAATGTGGAATCGCGCGGTGATGTG
CCGCTGATGGAAGCGCGAACGCGAACTCTGCTGACGTTGCTGAACGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:456
Protein Molecular Weight:50462
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Phosphomannomutase
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAK
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGD
TGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINVKNLTPLKLVINSGNG
AAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAA
GGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKDK
TLGELVRDRMAAFPASGEINSKLAQPVEAINRVEQHFSREALAVDRTDGISMTFADWRFN
LRTSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE
References
External Links:
ResourceLink
Uniprot ID:P24175
Uniprot Name:MANB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675199
Ecogene ID:EG10162
Ecocyc:EG10162
ColiBase:b2048
Kegg Gene:b2048
EchoBASE ID:EB0160
CCDB:MANB_ECOLI
BacMap:16129988
General Reference:
  • Aoyama, K., Haase, A. M., Reeves, P. R. (1994). "Evidence for effect of random genetic drift on G+C content after lateral transfer of fucose pathway genes to Escherichia coli K-12." Mol Biol Evol 11:829-838. Pubmed: 7815923
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Stevenson, G., Andrianopoulos, K., Hobbs, M., Reeves, P. R. (1996). "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." J Bacteriol 178:4885-4893. Pubmed: 8759852