Peptidyl-prolyl cis-trans isomerase B (P23869)

Identification
Name:Peptidyl-prolyl cis-trans isomerase B
Synonyms:
  • PPIase B
  • Rotamase B
Gene Name:ppiB
Enzyme Class:
Biological Properties
General Function:Posttranslational modification, protein turnover, chaperones
Specific Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Cellular Location:Cytoplasm
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
KEGG Reactions:
1.0Peptidylproline (omega=180) ↔ 1.0Peptidylproline (omega=0)
1.0Peptidylproline (omega=180) ↔ 1.0Peptidylproline (omega=0)
ReactionCard
Metabolites:
ECMDB IDNameView
GO Classification:
Function
catalytic activity
cis-trans isomerase activity
isomerase activity
peptidyl-prolyl cis-trans isomerase activity
Process
cellular protein metabolic process
macromolecule metabolic process
metabolic process
protein folding
protein metabolic process
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>495 bp
ATGGTTACTTTCCACACCAATCACGGCGATATTGTCATCAAAACTTTTGACGATAAAGCA
CCTGAAACAGTTAAAAACTTCCTGGACTACTGCCGCGAAGGTTTTTACAACAACACCATT
TTCCACCGTGTTATCAACGGCTTTATGATTCAGGGCGGCGGTTTTGAACCGGGCATGAAA
CAAAAAGCCACCAAAGAACCGATCAAAAACGAAGCCAACAACGGCCTGAAAAATACCCGT
GGTACGCTGGCAATGGCACGTACTCAGGCTCCGCACTCTGCAACTGCACAGTTCTTCATC
AACGTGGTTGATAACGACTTCCTGAACTTCTCTGGCGAAAGCCTGCAAGGTTGGGGCTAC
TGCGTGTTTGCTGAAGTGGTTGACGGCATGGACGAGGTAGACAAAATCAAAGGTGTTGCA
ACCGGTCGTAGCGGTATGCACCAGGACGTGCCAAAAGAAGACGTTATCATTGAAAGCGTG
ACCGTTAGCGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:164
Protein Molecular Weight:18153
Protein Theoretical pI:6
PDB File:2NUL
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Peptidyl-prolyl cis-trans isomerase B
MVTFHTNHGDIVIKTFDDKAPETVKNFLDYCREGFYNNTIFHRVINGFMIQGGGFEPGMK
QKATKEPIKNEANNGLKNTRGTLAMARTQAPHSATAQFFINVVDNDFLNFSGESLQGWGY
CVFAEVVDGMDVVDKIKGVATGRSGMHQDVPKEDVIIESVTVSE
References
External Links:
ResourceLink
Uniprot ID:P23869
Uniprot Name:PPIB_ECOLI
GenBank Gene ID:M55430
Genebank Protein ID:145290
PDB ID:2NUL
CCDB:PPIB_ECOLI
General Reference:
  • Avalos, J., Corrochano, L. M., Brenner, S. (1991). "Cysteinyl-tRNA synthetase is a direct descendant of the first aminoacyl-tRNA synthetase." FEBS Lett 286:176-180. Pubmed: 1864365
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Compton, L. A., Davis, J. M., Macdonald, J. R., Bachinger, H. P. (1992). "Structural and functional characterization of Escherichia coli peptidyl-prolyl cis-trans isomerases." Eur J Biochem 206:927-934. Pubmed: 1606970
  • Hayano, T., Takahashi, N., Kato, S., Maki, N., Suzuki, M. (1991). "Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells." Biochemistry 30:3041-3048. Pubmed: 2007139
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Konno, M., Ito, M., Hayano, T., Takahashi, N. (1996). "The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer." J Mol Biol 256:897-908. Pubmed: 8601841
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Wilkins, M. R., Gasteiger, E., Tonella, L., Ou, K., Tyler, M., Sanchez, J. C., Gooley, A. A., Walsh, B. J., Bairoch, A., Appel, R. D., Williams, K. L., Hochstrasser, D. F. (1998). "Protein identification with N and C-terminal sequence tags in proteome projects." J Mol Biol 278:599-608. Pubmed: 9600841