Identification
Name:Transcriptional regulatory protein PhoP
Synonyms:Not Available
Gene Name:phoP
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
  • Cationic antimicrobial peptide (CAMP) resistance eco01503
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cytoplasm
DNA binding
identical protein binding
phosphorelay signal transduction system
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>672
atgcgcgtactggttgttgaagacaatgcgttgttacgtcaccaccttaaagttcagatt
caggatgctggtcatcaggtcgatgacgcagaagatgccaaagaagccgattattatctc
aatgaacatataccggatattgcgattgtcgatctcggattgccagacgaggacggtctg
tcactgattcgccgctggcgtagcaacgatgtttcactgccgattctggtattaaccgcc
cgtgaaagctggcaggacaaagtcgaagtattaagtgccggtgctgatgattatgtgact
aaaccgtttcatattgaagaggtgatggcgcgaatgcaggcattaatgcggcgtaatagc
ggtctggcttcacaggtcatttcgctccccccgtttcaggttgatctctctcgccgtgaa
ttatctattaatgacgaagtgatcaaactgaccgcgttcgaatacactattatggaaacg
ttgatacgcaataatggcaaagtggtcagcaaagattcgttaatgctccaactctatccg
gatgcggagctgcgggaaagccataccattgatgtactgatgggacgtctgcgcaaaaaa
attcaggcacaatatccccaagaagtgattaccaccgttcgcggccagggctatctgttc
gaattgcgctga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:223
Protein Molecular Weight:25534
Protein Theoretical pI:Not Available
PDB File:2PKX
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Transcriptional regulatory protein PhoP
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHIPDIAIVDLGLPDEDGL
SLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNS
GLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
DAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
References
External Links:
ResourceLink
Uniprot ID:P23836
Uniprot Name:PHOP_ECOLI
PDB ID:2PKX
CCDB:PHOP_ECOLI
General Reference:Not Available