| Identification |
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| Name: | DNA mismatch repair protein MutL |
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| Synonyms: | Not Available |
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| Gene Name: | mutL |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | regulation of DNA recombination |
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| Specific Function: | This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | ATPase activity | | DNA binding | | identical protein binding | | mismatch repair | | mismatch repair complex | | mismatched DNA binding | | regulation of DNA recombination | | single-stranded DNA binding |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1848
atgccaattcaggtcttaccgccacaactggcgaaccagattgccgcaggtgaggtggtc
gagcgacctgcgtcggtagtcaaagaactagtggaaaacagcctcgatgcaggtgcgacg
cgtatcgatattgatatcgaacgcggtggggcgaaacttatccgcattcgtgataacggc
tgcggtatcaaaaaagatgagctggcgctggcgctggctcgtcatgccaccagtaaaatc
gcctctctggacgatctcgaagccattatcagcctgggctttcgcggtgaggcgctggcg
agtatcagttcggtttcccgcctgacgctcacttcacgcaccgcagaacagcaggaagcc
tggcaggcctatgccgaagggcgcgatatgaacgtgacggtaaaaccggcggcgcatcct
gtggggacgacgctggaggtgctggatctgttctacaacaccccggcgcggcgcaaattc
ctgcgcaccgagaaaaccgaatttaaccacattgatgagatcatccgccgcattgcgctg
gcgcgtttcgacgtcacgatcaacctgtcgcataacggtaaaattgtgcgtcagtaccgc
gcagtgccggaaggcgggcaaaaagaacggcgcttaggcgcgatttgcggcaccgctttt
cttgaacaagcgctggcgattgaatggcaacacggcgatctcacgctacgcggctgggtg
gccgatccaaatcacaccacgcccgcactggcagaaattcagtattgctacgtgaacggt
cgcatgatgcgcgatcgcctgatcaatcacgcgatccgccaggcctgcgaagacaaactg
ggggccgatcagcaaccggcatttgtgttgtatctggagatcgacccacatcaggtggac
gtcaacgtgcaccccgccaaacacgaagtgcgtttccatcagtcgcgtctggtgcatgat
tttatctatcagggcgtgctgagcgtgctacaacagcaactggaaacgccgctaccgctg
gacgatgaaccccaacctgcaccgcgttccattccggaaaaccgcgtggcggcggggcgc
aatcactttgcagaaccggcagctcgtgagccggtagctccgcgctacactcctgcgcca
gcatcaggcagtcgtccggctgccccctggccgaatgcgcagccaggctaccagaaacag
caaggtgaagtgtatcgccagcttttgcaaacgcccgcgccgatgcaaaaattaaaagcg
ccggaaccgcaggaacctgcacttgcggcgaacagtcagagttttggtcgggtactgact
atcgtccattccgactgtgcgttgctggagcgcgacggcaacatttcacttttatccttg
ccagtggcagaacgttggctgcgtcaggcacaattgacgccgggtgaagcgcccgtttgc
gcccagccgctgctgattccgttgcggctaaaagtttctgccgaagaaaaatcggcatta
gaaaaagcgcagtctgccctggcggaattgggtattgatttccagtcagatgcacagcat
gtgaccatcagggcagtgcctttacccttacgccaacaaaatttacaaatcttgattcct
gaactgataggctacctggcgaagcagtccgtattcgaacctggcaatattgcgcagtgg
attgcacgaaatctgatgagcgaacatgcgcagtggtcaatggcacaggccataaccctg
ctggcggacgtggaacggttatgtccgcaacttgtgaaaacgccgccgggtggtctgtta
caatctgttgatttacatccggcgataaaagccctgaaagatgagtga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 615 |
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| Protein Molecular Weight: | 67923 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1B62 |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >DNA mismatch repair protein MutL
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEA
WQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGR
NHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKLKA
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVC
AQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIP
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
QSVDLHPAIKALKDE |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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