| Identification |
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| Name: | Ribonuclease R |
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| Synonyms: | Not Available |
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| Gene Name: | rnr |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | rRNA processing |
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| Specific Function: | 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (rRNAs, tRNAs and SsrA/tmRNA). In stationary phase, involved in the post-transcriptional regulation of ompA mRNA stability. Shortens RNA processively to di- and trinucleotides. In vitro, exhibits helicase activity, which is independent of its RNase activity. Required for the expression of virulence genes in enteroinvasive strains of E.coli. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| 3'-5' RNA helicase activity | | 3'-5'-exoribonuclease activity | | cytoplasm | | exoribonuclease activity, producing 5'-phosphomonoesters | | exoribonuclease II activity | | exosome (RNase complex) | | mRNA catabolic process | | ncRNA processing | | pathogenesis | | response to cold | | ribonuclease activity | | ribonuclease R activity | | RNA binding | | RNA phosphodiester bond hydrolysis, exonucleolytic | | rRNA processing |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >2442
atgtcacaagatcctttccaggaacgcgaagctgaaaaatacgcgaatcccatccctagt
cgggaatttatcctcgaacatttaaccaaacgtgaaaaaccggccagccgtgatgagctg
gcggtagaactgcacattgaaggcgaagagcagcttgaaggcctgcgtcgccgcctgcgc
gcgatggagcgcgatggtcaactggtcttcactcgtcgtcagtgctatgcgctgccggaa
cgcctcgacctggtgaaaggtaccgttattggccaccgtgatggctacggctttctgcgg
gttgaagggcgtaaagatgatttgtatctctccagcgagcagatgaaaacctgcattcat
ggcgatcaggtgctggctcagccgctgggtgctgaccgtaaaggtcgtcgtgaagcgcgt
attgtccgcgtactggtgccaaaaaccagccagattgttggtcgctactttaccgaagcg
ggcgtcggctttgtggttcctgacgacagccgtctgagcttcgatatcttaatcccgccc
gatcagatcatgggcgcgcggatgggctttgtggtcgtagtcgaactgactcagcgtccg
actcgccgcaccaaagcggtgggtaaaatcgtcgaagtgctgggcgacaatatgggcacc
ggcatggcggttgatatcgctctgcgtacccatgaaattccgtacatctggccgcaggct
gttgagcaacaggttgccgggctgaaagaagaagtgccggaagaagcaaaagcgggccgt
gttgatctgcgcgatttaccgctggtcaccattgatggcgaagacgcccgtgactttgac
gatgcagtttactgcgagaaaaaacgcggcggcggctggcgtttatgggtcgcgattgcc
gacgtcagctactatgtgcgtccgtcaacgccgctggacagagaagcgcgtaaccgtggc
acgtcggtgtacttcccttcgcaggttatcccgatgctgccggaagtgctctctaacggc
ctgtgttcgctcaacccgcaggtagaccgcctgtgtatggtgtgcgagatgacggtttcg
tcgaaaggccgcctgacgggctacaaattctacgaagcggtgatgagctctcacgcgcgt
ctgacctacaccaaagtctggcatattctgcagggcgatcaggatctgcgcgagcagtac
gccccgctggttaagcatctcgaagagttgcataacctctataaagtgctggataaagcc
cgtgaagaacgcggtgggatctcatttgagagcgaagaagcgaagttcattttcaacgct
gaacgccgtattgaacgtatcgaacagacccagcgtaacgacgcgcacaaattaattgaa
gagtgcatgattctggcgaatatctcggcggcgcgtttcgttgagaaagcgaaagaaccg
gcactgttccgtattcacgacaagccgagcaccgaagcgattacctctttccgttcagtg
ctggcggagctggggctggaactgccgggcggtaacaagccggaaccgcgtgactacgcg
gagctgctggagtcggttgccgatcgtcctgatgcagaaatgctgcaaaccatgctgctg
cgctcgatgaaacaggcgatttacgatccagaaaaccgtggtcactttggcctggcattg
cagtcctatgcgcactttacttcgccgattcgtcgttatccagacctgacgctgcaccgc
gccattaaatatctgctggcgaaagagcaggggcatcagggcaacaccactgaaaccggc
ggctaccattattcgatggaagagatgctgcaactgggtcagcactgttcgatggcggaa
cgtcgtgccgacgaagcaacgcgcgatgtggctgactggctgaagtgtgacttcatgctc
gaccaggtaggtaacgtctttaaaggcgtaatttccagcgtcactggctttggcttcttc
gtccgtctggacgacttgttcattgatggtctggtccatgtctcttcgctggacaatgac
tactatcgctttgaccaggtagggcaacgcctgatgggggaatccagcggccagacttat
cgcctgggcgatcgcgtggaagttcgcgtcgaagcggttaatatggacgagcgcaaaatc
gactttagcctgatctccagcgaacgcgcaccgcgcaacgtcggtaaaacggcgcgcgag
aaagcgaaaaaaggcgatgcaggtaaaaaaggcggcaagcgtcgtcaggtcggtaaaaag
gtaaactttgagccagacagcgccttccgcggtgagaaaaaaacgaagccgaaagcggcg
aagaaagacgcgagaaaagcgaaaaagccatcggcgaaaacgcagaaaatagctgcagcg
accaaagcgaagcgtgcggcgaagaaaaaagtggcagagtga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 813 |
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| Protein Molecular Weight: | 92108 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Ribonuclease R
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASRDELAVELHIEGEEQLEGLRRRLR
AMERDGQLVFTRRQCYALPERLDLVKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIH
GDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTEAGVGFVVPDDSRLSFDILIPP
DQIMGARMGFVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDIALRTHEIPYIWPQA
VEQQVAGLKEEVPEEAKAGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
DVSYYVRPSTPLDREARNRGTSVYFPSQVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTVS
SKGRLTGYKFYEAVMSSHARLTYTKVWHILQGDQDLREQYAPLVKHLEELHNLYKVLDKA
REERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKAKEP
ALFRIHDKPSTEAITSFRSVLAELGLELPGGNKPEPRDYAELLESVADRPDAEMLQTMLL
RSMKQAIYDPENRGHFGLALQSYAHFTSPIRRYPDLTLHRAIKYLLAKEQGHQGNTTETG
GYHYSMEEMLQLGQHCSMAERRADEATRDVADWLKCDFMLDQVGNVFKGVISSVTGFGFF
VRLDDLFIDGLVHVSSLDNDYYRFDQVGQRLMGESSGQTYRLGDRVEVRVEAVNMDERKI
DFSLISSERAPRNVGKTAREKAKKGDAGKKGGKRRQVGKKVNFEPDSAFRGEKKTKPKAA
KKDARKAKKPSAKTQKIAAATKAKRAAKKKVAE |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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