| Identification |
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| Name: | DNA topoisomerase 4 subunit B |
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| Synonyms: | Not Available |
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| Gene Name: | parE |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | sister chromatid cohesion |
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| Specific Function: | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | chromosome | | chromosome organization | | chromosome segregation | | DNA binding | | DNA topoisomerase complex (ATP-hydrolyzing) | | DNA topoisomerase type II (ATP-hydrolyzing) activity | | DNA topological change | | DNA unwinding involved in DNA replication | | magnesium ion binding | | nucleoid | | plasmid partitioning | | response to antibiotic | | sister chromatid cohesion |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1893
atgacgcaaacttataacgctgatgccattgaggtactcaccgggcttgagccggttcgc
cgccgtccggggatgtataccgataccactcgccctaaccatttggggcaagaagtcatt
gataacagtgtggatgaagcactggcgggtcacgcaaaacgcgtggacgttattttacat
gctgaccagtcgttagaagttattgacgatgggcgcgggatgccggtggatattcacccg
gaagagggtgtaccggcggttgaactgattctttgccgtctgcatgcaggcggtaaattc
tctaacaaaaattaccagttctctggcggcctgcatggcgtggggatttcggtggttaac
gccctgtcgaagcgcgtagaagttaacgtgcgccgcgatggtcaggtttataacatcgcc
tttgaaaatggcgaaaaggtgcaggatttacaggttgtcggcacttgcggtaaacgcaat
actggtaccagtgtgcacttctggccggatgaaaccttctttgacagcccgcgattttct
gtttcacgcctgacgcatgtgctgaaagccaaagcggtattgtgccctggcgttgagatc
acttttaaagatgagatcaacaataccgaacaacgctggtgctatcaggacggtctgaat
gattacctggcggaagcggtaaatggtctgccgacgctgccggaaaaaccgtttatcggt
aatttcgctggtgatactgaagctgtggactgggcgctactgtggctgccggaaggcggt
gaactgctgaccgaaagctacgtcaaccttatcccaacgatgcagggcggtacccatgtt
aatggtctgcgtcagggcctgttggacgcgatgcgtgagttctgtgaataccgcaatatt
ctgccgcgcggtgtaaagctgtcggcggaagatatctgggatcgctgcgcctatgtgctg
tcagtaaaaatgcaggatccgcagtttgccgggcagacgaaagagcgtctctcttcgcgt
caatgcgcggcattcgtttctggcgtggtgaaagatgcctttatcctgtggctgaaccag
aacgttcaggcggctgaactgctggcggagatggcgatttccagcgcccagcgccgtatg
cgtgcggccaaaaaagtggtgcgtaaaaagctgaccagcggcccggcgttgcctggcaaa
ctggctgattgtaccgcgcaggaccttaaccgtaccgagctgttccttgtggaaggtgac
tccgcaggcggatctgccaagcaggcgcgcgatcgcgaatatcaggcgatcatgccactg
aaaggtaagatccttaacacctgggaagtctcttccgacgaagtgctggcttcgcaggaa
gtgcacgatatttcggtagcgatcggtatcgatcctgacagcgacgatctgagccagctt
cgttatggcaaaatctgtatcctcgcggatgcggactctgatggtctgcacattgccacg
ctgctctgcgctttgttcgtaaaacatttccgcgcgttggtgaaacacggtcacgtttac
gtcgcactgccaccgctctaccgtattgatctcgggaaagaggtttattacgcgctgacg
gaagaagagaaagagggcgtacttgagcaattaaaacgcaagaaaggcaagccgaacgtc
cagcgttttaaaggtctgggggaaatgaacccgatgcaattgcgcgaaaccacgcttgat
ccgaacactcgccgtctggtgcagttgactatcgatgatgaagacgatcagcgtactgac
gcgatgatggatatgctgctggcgaagaaacgctcggaagatcgccgcaactggttgcaa
gagaaaggcgacatggcggagattgaggtttaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 630 |
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| Protein Molecular Weight: | 70243 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1S14 |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >DNA topoisomerase 4 subunit B
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
ALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFS
VSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIG
NFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQ
NVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALT
EEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTD
AMMDMLLAKKRSEDRRNWLQEKGDMAEIEV |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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