Glucuronide carrier protein (P0CE45)

Identification
Name:Glucuronide carrier protein
Synonyms:
  • Glucuronide permease
Gene Name:uidB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by uidC (gusC, AC Q47706)
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
  • hexuronide and hexuronate degradation PW000834
KEGG Pathways:Not Available
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
Metabolites:
ECMDB IDNameView
ECMDB03325Bilirubin diglucuronideMetaboCard
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
cation transport
establishment of localization
ion transport
monovalent inorganic cation transport
sodium ion transport
transmembrane transport
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1374 bp
ATGAATCAACAACTCTCCTGGCGCACCATCGTCGGCTACAGCCTCGGTGACGTCGCCAAT
AACTTCGCCTTCGCAATGGGGGCGCTCTTCCTGTTGAGTTACTACACCGACGTCGCTGGC
GTCGGTGCCGCTGCGGCGGGCACCATGCTGTTACTGGTGCGGGTATTCGATGCCTTCGCC
GACGTCTTTGCCGGACGAGTGGTGGACAGTGTGAATACCCGCTGGGGAAAATTCCGCCCG
TTTTTACTCTTCGGTACTGCGCCGTTAATGATCTTCAGCGTGCTGGTATTCTGGGTGCCG
ACCGACTGGAGCCATGGTAGCAAAGTGGTGTATGCATATTTGACCTACATGGGCCTCGGG
CTTTGCTACAGCCTGGTGAATATTCCTTATGGTTCACTTGCTACCGCGATGACCCAACAA
CCACAATCCCGCGCCCGTCTGGGCGCGGCTCGTGGGATTGCCGCTTCATTGACCTTTGTC
TGCCTGGCATTTCTGATAGGACCGAGCATTAAGAACTCCAGCCCGGAAGAGATGGTGTCG
GTATACCATTTCTGGACAATTGTGCTGGCGATTGCCGGAATGGTGCTTTACTTCATCTGC
TTCAAATCGACGCGTGAGAATGTGGTACGTATCGTTGCGCAGCCGTCATTGAATATCAGT
CTGCAAACCCTGAAACGGAATCGCCCGCTGTTTATGTTGTGCATCGGTGCGCTGTGTGTG
CTGATTTCGACCTTTGCGGTCAGCGCCTCGTCGTTGTTCTACGTGCGCTATGTGTTAAAT
GATACCGGGCTGTTCACTGTGCTGGTACTGGTGCAAAACCTGGTTGGTACTGTGGCATCG
GCACCGCTGGTGCCGGGGATGGTCGCGAGGATCGGTAAAAAGAATACCTTCCTGATTGGC
GCTTTGCTGGGAACCTGCGGTTATCTGCTGTTCTTCTGGGTTTCCGTCTGGTCACTGCCG
GTGGCGTTGGTTGCGTTGGCCATCGCTTCAATTGGTCAGGGCGTTACCATGACCGTGATG
TGGGCGCTGGAAGCTGATACCGTAGAATACGGTGAATACCTGACCGGCGTGCGAATTGAA
GGGCTCACCTATTCACTATTCTCATTTACCCGTAAATGCGGTCAGGCAATCGGAGGTTCA
ATTCCTGCCTTTATTTTGGGGTTAAGCGGATATATCGCCAATCAGGTGCAAACGCCGGAA
GTTATTATGGGCATCCGCACATCAATTGCCTTAGTACCTTGCGGATTTATGCTACTGGCA
TTCGTTATTATCTGGTTTTATCCGCTCACGGATAAAAAATTCAAAGAAATCGTGGTTGAA
ATTGATAATCGTAAAAAAGTGCAGCAGCAATTAATCAGCGATATCACTAATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:457
Protein Molecular Weight:49892
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 12-34
  • 38-60
  • 80-100
  • 109-129
  • 147-167
  • 181-201
  • 229-249
  • 264-284
  • 297-316
  • 321-343
  • 373-393
  • 409-429
Protein Sequence:
>Glucuronide carrier protein
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFA
DVFAGRVVDSVNTRWGKFRPFLLFGTAPLMIFSVLVFWVPTDWSHGSKVVYAYLTYMGLG
LCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAFLIGPSIKNSSPEEMVS
VYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLNISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIG
ALLGTCGYLLFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIE
GLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQTPEVIMGIRTSIALVPCGFMLLA
FVIIWFYPLTDKKFKEIVVEIDNRKKVQQQLISDITN
References
External Links:
ResourceLink
Uniprot ID:P0CE45
Uniprot Name:UIDB2_ECOLI
GenBank Gene ID:M14641
Genebank Protein ID:868021
EchoBASE ID:EB1610
CCDB:UIDB2_ECOLI
General Reference:
  • Jefferson, R. A., Burgess, S. M., Hirsh, D. (1986). "beta-Glucuronidase from Escherichia coli as a gene-fusion marker." Proc Natl Acad Sci U S A 83:8447-8451. Pubmed: 3534890
  • Liang, W. J., Wilson, K. J., Xie, H., Knol, J., Suzuki, S., Rutherford, N. G., Henderson, P. J., Jefferson, R. A. (2005). "The gusBC genes of Escherichia coli encode a glucuronide transport system." J Bacteriol 187:2377-2385. Pubmed: 15774881