| Identification |
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| Name: | Small-conductance mechanosensitive channel |
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| Synonyms: | Not Available |
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| Gene Name: | mscS |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | ion transmembrane transport |
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| Specific Function: | Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds.The channel pore is formed by TM3 and the loop between TM2 and TM3. After a sharp turn at Gly-113, an alpha-helix (residues 114-127) is oriented nearly parallel to the plane of the putative lipid bilayer. On the intracellular side of the channel, the permeation pathway of MscS does not connect directly to the cytoplasm but instead opens to a large chamber that is connected to the cytoplasm. This chamber resembles a molecular filter that could serve to prescreen large molecules before they are allowed passage to the transmembrane pore. The TM1 and TM2 helices appear to be likely candidates for mediating the tension and voltage sensitivities of MscS. Gating requires large rearrangements of at least the C-terminus. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cellular water homeostasis | | integral component of membrane | | ion transmembrane transport | | mechanically-gated ion channel activity | | plasma membrane |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >861
atggaagatttgaatgttgtcgatagcataaacggcgcgggaagctggctggtagctaac
caggcgctgctgctaagttatgcagtaaacatcgtggcggcactcgcgatcatcatcgtt
ggtttgattatcgcgcggatgatttccaacgcggtgaatcgcctgatgatctcccgtaaa
atcgatgccactgttgctgattttctttctgcattagtccgttacggtattatcgccttt
acgctaatcgctgcactgggacgcgtgggtgtacaaaccgcgtcagtcattgctgtactc
ggtgccgcaggcttagctgttggtctggctttgcaggggtcactgtctaacctggccgct
ggcgtgttacttgtcatgttccgcccgttccgtgccggagaatatgttgacctgggcggc
gtagccggtactgtgctgagtgtgcagattttctccaccaccatgcgtactgcagacggt
aaaattatcgttattccgaacggtaaaattattgccggaaatattattaacttctcccgc
gagccagttcgccgtaacgaatttattattggcgtggcgtatgattccgatatcgatcag
gttaagcagatcctgaccaatattatccagtctgaagatcgcattttgaaagatcgcgaa
atgactgtgcgcctgaacgaacttggtgcatcgtcgattaatttcgtggtccgcgtctgg
agcaacagcggcgatctgcaaaacgtgtactgggatgtgctggagcgtattaaacgtgaa
tttgatgccgccggtatcagcttcccgtacccgcaaatggatgtgaactttaagcgggtg
aaagaagacaaagctgcgtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 286 |
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| Protein Molecular Weight: | 30895 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2OAU |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Small-conductance mechanosensitive channel
MEDLNVVDSINGAGSWLVANQALLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRK
IDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAA
GVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSR
EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVW
SNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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