| Identification |
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| Name: | Signal recognition particle protein |
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| Synonyms: | Not Available |
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| Gene Name: | ffh |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | SRP-dependent cotranslational protein targeting to membrane |
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| Specific Function: | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| 7S RNA binding | | GTP binding | | GTPase activity | | metabolic process | | protein targeting to membrane | | ribonucleoprotein complex | | signal recognition particle | | SRP-dependent cotranslational protein targeting to membrane |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1362
atgtttgataatttaaccgatcgtttgtcgcgcacgctgcgcaatatcagtggccgtgga
cgcctcactgaagacaacgtaaaagatacgctgcgcgaagtgcgcatggcgctgctggag
gcggacgtagctctgccggtagtgcgtgagtttatcaatcgcgtaaaagagaaagcggtt
ggtcatgaagttaataagagcctgacgccggggcaggagttcgtcaaaatagtccgtaac
gaactggttgcggcgatgggcgaagagaaccagaccctgaacctggctgcgcaaccgcct
gcggtcgtactgatggcgggcctgcaaggtgccggtaaaacaaccagcgttggtaaactc
ggtaagttcctgcgcgagaagcacaagaagaaagtgctggtggtttctgccgacgtttat
cgcccggcggcaatcaaacagcttgagacgctggcagagcaggtgggcgttgatttcttc
ccttctgatgttggtcagaagccggtagatatcgttaacgcggcgctgaaagaagccaaa
ctgaaattctacgacgtgctgctggtggataccgctggtcgtctgcacgttgacgaagcg
atgatggacgagatcaaacaagtccatgcgtcgattaacccggttgaaaccctgtttgtg
gttgacgccatgaccggtcaggatgcggccaatacggcaaaagcattcaatgaagcgtta
ccgcttaccggcgtagtgttgaccaaagtggacggcgatgcccgcggcggtgcggcgctc
tctattcgtcacatcactggcaaaccgatcaagttcctcggtgttggcgagaaaactgag
gcgctggagccgttccatccggaccgcatcgcgtcgcgtattctcggcatgggcgacgta
ctgtcgctgatcgaagatatcgaaagcaaagttgaccgcgcgcaggcagagaaattagcc
agcaagctgaaaaaaggtgacggcttcgatctcaacgactttcttgagcagctgcgccag
atgaaaaatatgggcggcatggctagtctgatgggcaagctgccgggcatggggcagatc
ccggataacgtcaagtcacagatggacgataaagtgctggtgcgtatggaagccatcatc
aactcgatgacgatgaaagagcgcgctaagccagaaatcatcaaaggttcgcgtaaacgc
cgtattgctgccggttgcggtatgcaggtgcaggacgttaaccgtcttctgaaacagttc
gacgacatgcagcgcatgatgaagaaaatgaagaagggcggaatggcgaagatgatgaga
agcatgaagggtatgatgcccccaggcttccctggtcgctaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 453 |
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| Protein Molecular Weight: | 49786 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1DUL |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Signal recognition particle protein
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAV
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKL
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
LKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDV
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQI
PDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
DDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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