| Identification |
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| Name: | Protein translocase subunit SecY |
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| Synonyms: | Not Available |
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| Gene Name: | secY |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | protein transport by the Sec complex |
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| Specific Function: | The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Transports: | |
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| Transport References: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| integral component of membrane | | integral component of plasma membrane | | intracellular | | intracellular protein transmembrane transport | | intracellular protein transport | | plasma membrane | | protein targeting | | protein transport by the Sec complex |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1332
atggctaaacaaccgggattagattttcaaagtgccaaaggtggcttaggcgagctgaaa
cgcagactgctgtttgttatcggtgcgctgattgtgttccgtattggctcttttattccg
atccctggtattgatgccgctgtacttgccaaactgcttgagcaacagcgaggcaccatc
attgagatgtttaacatgttctctggtggtgctctcagccgtgcttctatctttgctctg
gggatcatgccgtatatttcggcgtcgatcattatccagctgctgacggtggttcaccca
acgttggcagaaattaagaaagaaggggagtctggtcgtcgtaagatcagccagtacacc
cgctacggtactctggtgctggcaatattccagtcgatcggtattgctaccggtctgccg
aatatgcctggtatgcaaggcctggtgattaacccgggctttgcattctacttcaccgct
gttgtaagtctggtcacaggaaccatgttcctgatgtggttgggcgaacagattactgaa
cgaggtatcggcaacggtatttcaatcattatcttcgccggtattgtcgcgggactcccg
ccagccattgcccatactatcgagcaagcgcgtcaaggcgacctgcacttcctcgtgttg
ctgttggttgcagtattagtatttgcagtgacgttctttgttgtatttgttgagcgtggt
caacgccgcattgtggtaaactacgcgaaacgtcagcaaggtcgtcgtgtctatgctgca
cagagcacacatttaccgctgaaagtgaatatggcgggggtaatcccggcaatcttcgct
tccagtattattctgttcccggcgaccatcgcgtcatggttcgggggcggtactggttgg
aactggctgacaacaatttcgctgtatttgcagcctgggcaaccgctttatgtgttactc
tatgcgtctgcaatcatcttcttctgtttcttctacacggcgttggttttcaacccgcgt
gaaacagcagataacctgaagaagtccggtgcatttgtaccaggaattcgtccgggagag
caaacggcgaagtatatcgataaagtaatgacccgcctgaccctggttggtgcgctgtat
attacctttatctgcctgatcccggagttcatgcgtgatgcaatgaaagtaccgttctac
ttcggtgggacctcactgcttatcgttgttgtcgtgattatggactttatggctcaagtg
caaactctgatgatgtccagtcagtatgagtctgcattgaagaaggcgaacctgaaaggc
tacggccgataa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 443 |
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| Protein Molecular Weight: | 48511 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2AKH |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | - 23-35
- 61-96
- 116-131
- 165-178
- 184-200
- 224-237
- 274-287
- 314-329
- 381-395
- 397-413
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| Protein Sequence: | >Protein translocase subunit SecY
MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTI
IEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYT
RYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITE
RGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERG
QRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGW
NWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGE
QTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYFGGTSLLIVVVVIMDFMAQV
QTLMMSSQYESALKKANLKGYGR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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