Protein translocase subunit SecY (P0AGA2)

Identification
Name:Protein translocase subunit SecY
Synonyms:Not Available
Gene Name:secY
Enzyme Class:Not Available
Biological Properties
General Function:protein transport by the Sec complex
Specific Function:The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
Metabolites:
ECMDB IDNameView
GO Classification:
Function
integral component of membrane
integral component of plasma membrane
intracellular
intracellular protein transmembrane transport
intracellular protein transport
plasma membrane
protein targeting
protein transport by the Sec complex
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1332
atggctaaacaaccgggattagattttcaaagtgccaaaggtggcttaggcgagctgaaa
cgcagactgctgtttgttatcggtgcgctgattgtgttccgtattggctcttttattccg
atccctggtattgatgccgctgtacttgccaaactgcttgagcaacagcgaggcaccatc
attgagatgtttaacatgttctctggtggtgctctcagccgtgcttctatctttgctctg
gggatcatgccgtatatttcggcgtcgatcattatccagctgctgacggtggttcaccca
acgttggcagaaattaagaaagaaggggagtctggtcgtcgtaagatcagccagtacacc
cgctacggtactctggtgctggcaatattccagtcgatcggtattgctaccggtctgccg
aatatgcctggtatgcaaggcctggtgattaacccgggctttgcattctacttcaccgct
gttgtaagtctggtcacaggaaccatgttcctgatgtggttgggcgaacagattactgaa
cgaggtatcggcaacggtatttcaatcattatcttcgccggtattgtcgcgggactcccg
ccagccattgcccatactatcgagcaagcgcgtcaaggcgacctgcacttcctcgtgttg
ctgttggttgcagtattagtatttgcagtgacgttctttgttgtatttgttgagcgtggt
caacgccgcattgtggtaaactacgcgaaacgtcagcaaggtcgtcgtgtctatgctgca
cagagcacacatttaccgctgaaagtgaatatggcgggggtaatcccggcaatcttcgct
tccagtattattctgttcccggcgaccatcgcgtcatggttcgggggcggtactggttgg
aactggctgacaacaatttcgctgtatttgcagcctgggcaaccgctttatgtgttactc
tatgcgtctgcaatcatcttcttctgtttcttctacacggcgttggttttcaacccgcgt
gaaacagcagataacctgaagaagtccggtgcatttgtaccaggaattcgtccgggagag
caaacggcgaagtatatcgataaagtaatgacccgcctgaccctggttggtgcgctgtat
attacctttatctgcctgatcccggagttcatgcgtgatgcaatgaaagtaccgttctac
ttcggtgggacctcactgcttatcgttgttgtcgtgattatggactttatggctcaagtg
caaactctgatgatgtccagtcagtatgagtctgcattgaagaaggcgaacctgaaaggc
tacggccgataa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:443
Protein Molecular Weight:48511
Protein Theoretical pI:Not Available
PDB File:2AKH
Signaling Regions:Not Available
Transmembrane Regions:
  • 23-35
  • 61-96
  • 116-131
  • 165-178
  • 184-200
  • 224-237
  • 274-287
  • 314-329
  • 381-395
  • 397-413
Protein Sequence:
>Protein translocase subunit SecY
MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTI
IEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYT
RYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITE
RGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERG
QRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGW
NWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGE
QTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYFGGTSLLIVVVVIMDFMAQV
QTLMMSSQYESALKKANLKGYGR
References
External Links:
ResourceLink
Uniprot ID:P0AGA2
Uniprot Name:SECY_ECOLI
PDB ID:2AKH
CCDB:SECY_ECOLI
General Reference:Not Available