| Identification |
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| Name: | Protein translocase subunit SecF |
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| Synonyms: | Not Available |
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| Gene Name: | secF |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | protein transport by the Sec complex |
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| Specific Function: | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. The large periplasmic domain is thought to have a base and head domain joined by a hinge; movement of the hinge may be coupled to both proton transport and protein export, with the head domain capturing substrate, and a conformational change preventing backward movement and driving forward movement. Expression of V.alginolyticus SecD and SecF in E.coli confers Na(+)-dependent protein export, strongly suggesting SecDF functions via cation-coupled protein translocation. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| integral component of membrane | | intracellular | | intracellular protein transmembrane transport | | P-P-bond-hydrolysis-driven protein transmembrane transporter activity | | plasma membrane | | protein targeting | | protein transport by the Sec complex |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >972
gtggcacaggaatatactgttgaacaactaaaccacggccgtaaagtctatgactttatg
cgctgggactactgggctttcggcatctctggtctgctgttaatcgctgctatcgttatt
atgggcgtgcgcggctttaactgggggctggatttcaccggtggtacggttattgaaatt
acgctcgaaaaaccggctgaaattgacgtaatgcgtgatgcattgcaaaaagccggtttt
gaagagccgatgctgcaaaactttggtagcagccatgacatcatggtccgtatgccgcct
gctgaaggcgaaaccggcggtcaggtgttgggcagccaggttctgaaggtgattaacgaa
tccaccaatcagaatgcagcagtgaagcgtattgagttcgtcggtccgagcgtgggggca
gaccttgcgcaaaccggtgcgatggcgttgatggcagcgctgctgtctatcctcgtgtac
gtaggtttccgctttgagtggcgactggcggcaggggtggttattgcgctggcgcacgac
gttatcattacgctgggtattttgtcgttattccatatcgagattgacctgaccattgtg
gcatcgttgatgtcggttatcggttactcgcttaacgacagtatcgtggtatcggaccgt
attcgtgaaaacttccgcaagatccgtcgcggtacgccttacgaaatctttaacgtgtcc
ttgacccagacgctgcaccgtaccttgatcacatccggtactaccttgatggttatcctg
atgctgtacctcttcggtggtccggtactggaaggcttctcgctgaccatgcttatcggt
gtttccatcggtactgcatcttccatctatgtggcatctgcgttggctctgaaactgggt
atgaagcgcgaacacatgttgcagcagaaagtggaaaaagaaggggcggatcagccgtca
attctgccgtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 323 |
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| Protein Molecular Weight: | 35382 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | - 23-43
- 143-163
- 171-191
- 197-217
- 248-270
- 281-301
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| Protein Sequence: | >Protein translocase subunit SecF
MAQEYTVEQLNHGRKVYDFMRWDYWAFGISGLLLIAAIVIMGVRGFNWGLDFTGGTVIEI
TLEKPAEIDVMRDALQKAGFEEPMLQNFGSSHDIMVRMPPAEGETGGQVLGSQVLKVINE
STNQNAAVKRIEFVGPSVGADLAQTGAMALMAALLSILVYVGFRFEWRLAAGVVIALAHD
VIITLGILSLFHIEIDLTIVASLMSVIGYSLNDSIVVSDRIRENFRKIRRGTPYEIFNVS
LTQTLHRTLITSGTTLMVILMLYLFGGPVLEGFSLTMLIGVSIGTASSIYVASALALKLG
MKREHMLQQKVEKEGADQPSILP |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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