| Identification |
|---|
| Name: | Protein translocase subunit SecD |
|---|
| Synonyms: | Not Available |
|---|
| Gene Name: | secD |
|---|
| Enzyme Class: | Not Available |
|---|
| Biological Properties |
|---|
| General Function: | protein transport by the Sec complex |
|---|
| Specific Function: | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. The large periplasmic domain is thought to have a base and head domain joined by a hinge; movement of the hinge may be coupled to both proton transport and protein export, with the head domain capturing substrate, and a conformational change preventing backward movement and driving forward movement. Expression of V.alginolyticus SecD and SecF in E.coli confers Na(+)-dependent protein export, strongly suggesting SecDF functions via cation-coupled protein translocation. |
|---|
| Cellular Location: | Not Available |
|---|
| SMPDB Pathways: | Not Available |
|---|
| KEGG Pathways: | |
|---|
| Metabolites: | |
|---|
| GO Classification: | | Function |
|---|
| integral component of membrane | | intracellular | | intracellular protein transmembrane transport | | P-P-bond-hydrolysis-driven protein transmembrane transporter activity | | plasma membrane | | protein targeting | | protein transport | | protein transport by the Sec complex |
|
|---|
| Gene Properties |
|---|
| Blattner: | Not Available |
|---|
| Gene Orientation | Not Available |
|---|
| Centisome Percentage: | Not Available |
|---|
| Left Sequence End | Not Available |
|---|
| Right Sequence End | Not Available |
|---|
| Gene Sequence: | >1848
gtgttaaaccgttatcctttgtggaagtacgtcatgctgatcgtggtgattgtcatcggt
ctgctgtatgcgcttcccaacctgtttggtgaggatccggctgttcagatcactggtgcg
cgcggagtcgccgccagtgagcaaacgctgatccaggtccagaaaacgttacaagaagaa
aaaataactgctaagtctgtggcactggaagagggcgctattcttgcgcgcttcgactcc
actgacacccagttgcgcgctcgtgaagcattaatgggcgttatgggtgacaaatacgtc
gtggcgcttaaccttgccccggcaacgccgcgctggctggcagctattcacgctgagccg
atgaagctcggccttgacctgcgtggcggcgttcacttcctgatggaagtggatatggac
accgcgcttggcaaactccaggaacaaaatatcgatagcctacgcagtgacctgcgcgaa
aagggcatcccgtataccactgttcgtaaagaaaacaactacggcctgagcatcactttc
cgcgatgctaaagctcgtgatgaagccattgcgtatctgagcaagcgccatccggacctg
gtgattagcagccagggcagcaaccagctgcgtgcggtaatgagcgatgctcgtctgagt
gaagcgcgtgaatatgcggtgcagcagaacattaatatcctgcgtaaccgtgtaaaccaa
cttggcgtggcggagccggtggttcagcgtcagggtgctgaccgtatcgttgttgaactg
ccaggtattcaggacactgcgcgtgcgaaagagattctgggtgcgacggcaacgctggaa
ttccgtctggtaaacaccaacgttgaccaggccgctgcggcatccggtcgcgtaccgggc
gactctgaagtgaaacagacccgcgaaggtcagccagttgtgctgtacaaacgcgtaatt
ctgaccggtgaccatatcaccgactccacttccagccaggacgaatacaaccaaccgcag
gttaacatctcgctcgatagcgctggtggtaacatcatgtctaacttcactaaggacaac
atcggcaaaccgatggcaaccctgtttgtggagtacaaagacagcggtaagaaagatgca
aatggtcgtgcggttctggtgaaacaggaagaggtgattaacatcgccaacatccagtct
cgtctgggtaacagcttccgtatcaccggcatcaacaacccgaacgaagcccgtcagctg
tcactgctgctgcgtgccggtgcgttgatcgcgccgattcagattgttgaagaacgtacc
attggcccaaccctgggtatgcagaacattgaacaggggctggaggcttgccttgccggt
ctgctggtttctattctgttcatgatcatcttctataagaagtttggtctgattgcgacc
agtgctctgattgccaacttgatcttaatcgtcggcattatgtcgctgttgccaggcgca
acgctgagtatgccaggtatcgcgggtatcgtcttaacccttgcggtggcggtcgatgcg
aacgtactgatcaacgaacgtattaaagaagagttgagcaacggacgtactgttcaacag
gcaattgatgaaggttatcgtggcgcattcagttctatcttcgatgcgaacatcaccacg
ctgattaaagtcatcatcctgtacgcagtgggtaccggggcaattaaagggttcgcgatt
actaccggtatcggtgtggcgacgtcgatgtttaccgcgattgtcggtacgcgtgccatc
gtaaacctgctatatggcggcaagcgcgtcaagaagctgtcaatctga |
|---|
| Protein Properties |
|---|
| Pfam Domain Function: | Not Available |
|---|
| Protein Residues: | 615 |
|---|
| Protein Molecular Weight: | 66631 |
|---|
| Protein Theoretical pI: | Not Available |
|---|
| Signaling Regions: | Not Available |
|---|
| Transmembrane Regions: | - 10-29
- 456-472
- 502-518
- 564-580
- 586-605
|
|---|
| Protein Sequence: | >Protein translocase subunit SecD
MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEE
KITAKSVALEEGAILARFDSTDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEP
MKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLREKGIPYTTVRKENNYGLSITF
RDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQ
LGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPG
DSEVKQTREGQPVVLYKRVILTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDN
IGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQSRLGNSFRITGINNPNEARQL
SLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIAT
SALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQ
AIDEGYRGAFSSIFDANITTLIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAI
VNLLYGGKRVKKLSI |
|---|
| References |
|---|
| External Links: | |
|---|
| General Reference: | Not Available |
|---|
