| Identification |
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| Name: | DNA topoisomerase 4 subunit A |
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| Synonyms: | Not Available |
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| Gene Name: | parC |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | sister chromatid cohesion |
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| Specific Function: | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | chromosome | | chromosome segregation | | cytoplasm | | DNA binding | | DNA topoisomerase complex (ATP-hydrolyzing) | | DNA topoisomerase type II (ATP-hydrolyzing) activity | | DNA topological change | | DNA unwinding involved in DNA replication | | extrinsic component of plasma membrane | | nucleoid | | plasmid partitioning | | sister chromatid cohesion |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >2259
atgagcgatatggcagagcgccttgcgctacatgaatttacggaaaacgcctacttaaac
tactccatgtacgtgatcatggaccgtgcgttgccgtttattggtgatggtctgaaacct
gttcagcgccgcattgtgtatgcgatgtctgaactgggcctgaatgccagcgccaaattt
aaaaaatcggcccgtaccgtcggtgacgtactgggtaaataccatccgcacggcgatagc
gcctgttatgaagcgatggtcctgatggcgcaaccgttctcttaccgttatccgctggtt
gatggtcaggggaactggggcgcgccggacgatccgaaatcgttcgcggcaatgcgttac
accgaatcccggttgtcgaaatattccgagctgctattgagcgagctggggcaggggacg
gctgactgggtgccaaacttcgacggcactttgcaggagccgaaaatgctacctgcccgt
ctgccaaacattttgcttaacggcaccaccggtattgccgtcggcatggcgaccgatatt
ccaccgcataacctgcgtgaagtggctcaggcggcaatcgcattaatcgaccagccgaaa
accacgctcgatcagctgctggatatcgtgcaggggccggattatccgactgaagcggaa
attatcacttcgcgcgccgagatccgtaaaatctacgagaacggacgtggttcagtgcgt
atgcgcgcggtgtggaagaaagaagatggcgcggtggttatcagcgcattgccgcatcag
gtttcaggtgcgcgcgtactggagcaaattgctgcgcaaatgcgcaacaaaaagctgccg
atggttgacgatctgcgcgatgaatctgaccacgagaacccgacccgcctggtgattgtg
ccgcgttccaaccgcgtggatatggatcaggtgatgaaccacctcttcgctaccaccgat
ctggaaaagagctatcgtattaaccttaatatgatcggtctggatggtcgtccggcggtg
aaaaacctgctggaaatcctctccgaatggctggtgttccgccgcgataccgtgcgccgc
cgactgaactatcgtctggagaaagtcctcaagcgcctgcatatcctcgaaggtttgctg
gtggcgtttctcaatatcgacgaagtgattgagatcattcgtaatgaagatgaaccgaaa
ccggcgctgatgtcgcggtttggccttacggaaacccaggcggaagcgatcctcgaactg
aaactgcgtcatcttgccaaactggaagagatgaagattcgcggtgagcagagtgaactg
gaaaaagagcgcgaccagttgcagggcattttggcttccgagcgtaaaatgaataacctg
ctgaagaaagaactgcaggcagacgcgcaagcctacggtgacgatcgtcgttcgccgttg
caggaacgcgaagaagcgaaagcgatgagcgagcacgacatgctgccgtctgaacctgtc
accattgtgctgtcgcagatgggctgggtacgcagcgctaaaggccatgatatcgacgcg
ccgggcctgaattataaagcgggtgatagcttcaaagcggcggtgaaaggtaagagcaac
caaccggtagtgtttgttgattccaccggtcgtagctatgccattgacccgattacgctg
ccgtcggcgcgtggtcagggcgagccgctcaccggcaaattaacgttgccgcctggggcg
accgttgaccatatgctgatggaaagcgacgatcagaaactgctgatggcttccgatgcg
ggttacggtttcgtctgcacctttaacgatctggtggcgcgtaaccgtgcaggtaaggct
ttgatcaccttaccggaaaatgcccatgttatgccgccggtggtgattgaagatgcttcc
gatatgctgctggcaatcactcaggcaggccgtatgttgatgttcccggtaagtgatctg
ccgcagctgtcgaagggcaaaggcaacaagattatcaacattccatcggcagaagccgcg
cgtggagaagatggtctggcgcaattgtacgttctgccgccgcaaagcacgctgaccatt
catgttgggaaacgcaaaattaaactgcgcccggaagagttacagaaagtcactggcgaa
cgtggacgccgcggtacgttgatgcgcggtttgcagcgtatcgatcgtgttgagatcgac
tctcctcgccgtgccagcagcggtgatagcgaagagtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 752 |
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| Protein Molecular Weight: | 83830 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1ZVT |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >DNA topoisomerase 4 subunit A
MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDI
PPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVR
MRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIV
PRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRR
RLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPL
QEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSN
QPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDA
GYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDL
PQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGE
RGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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