Endoribonuclease GhoS (P0AF61)

Identification
Name:Endoribonuclease GhoS
Synonyms:Not Available
Gene Name:ghoS
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:Antitoxin component of a type V toxin-antitoxin (TA) module. Neutralizes the toxic effects of toxin GhoT by digesting ghoT transcripts in a sequence-specific manner (PubMed:22941047). In concert with GhoT is involved in reducing cell growth during antibacterial stress (PubMed:24373067). Overexpression leads to transcript level reduction of 20 other mRNAs involved in purine or pyrimidine synthesis and transport. Not seen to bind its own promoter DNA (PubMed:22941047).
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
endoribonuclease activity
regulation of transcription, DNA-templated
RNA phosphodiester bond hydrolysis, endonucleolytic
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>297
atggaaggtaaaaacaagttcaatacttatgttgtttcttttgattatccatcatcttat
tcctcagtgttcttaagattaagatcattgatgtatgatatgaatttctcctctatcgtg
gctgatgaatatgggataccacgacaattgaatgaaaactccttcgcaataacgacatcg
ttagccgcaagtgaaatcgaagatttaatcaggctcaaatgcttagacttaccggatatt
gattttgacctcaacattatgacagttgatgactatttccgtcagttttacaagtag
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:98
Protein Molecular Weight:11467
Protein Theoretical pI:Not Available
PDB File:2LLZ
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Endoribonuclease GhoS
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTS
LAASEIEDLIRLKCLDLPDIDFDLNIMTVDDYFRQFYK
References
External Links:
ResourceLink
Uniprot ID:P0AF61
Uniprot Name:GHOS_ECOLI
PDB ID:2LLZ
CCDB:GHOS_ECOLI
General Reference:Not Available