Identification
Name:L-fucose mutarotase
Synonyms:
  • Fucose 1-epimerase
  • Type-2 mutarotase
Gene Name:fucU
Enzyme Class:
Biological Properties
General Function:Involved in racemase and epimerase activity
Specific Function:Involved in the anomeric conversion of L-fucose. It also exhibits a pyranase activity for D-ribose
Cellular Location:Cytoplasm (Potential)
SMPDB Pathways:
KEGG Pathways:Not Available
KEGG Reactions:
1.0Thumb1.0Thumb
SMPDB Reactions:
1.0Thumb1.0Thumb
Metabolites:
ECMDB IDNameView
ECMDB24212 β-L-fucopyranoseMetaboCard
ECMDB20264alpha-L-FucoseMetaboCard
GO Classification:
Process
carbohydrate transport
establishment of localization
transport
Gene Properties
Blattner:b2804
Gene OrientationClockwise
Centisome Percentage:63.30
Left Sequence End2936910
Right Sequence End2937332
Gene Sequence:
>423 bp
ATGATTGTGATTTCCCGACATGTTGCTATTCCCGATGGTGAGCTTGAGATCACCGCCATT
CGTGCGCAGGGCGCGGGCGGGCAGCATGTTAATAAGACCTCAACGGCTATTCATCTGCGT
TTTGACATTCGGGCGTCCAGCCTGCCAGAGTATTACAAAGAGCGTCTGCTCGCCGCCAGC
CATCATTTGATCAGCAGTGATGGCGTGATTGTCATTAAGGCACAGGAATACCGCAGTCAG
GAACTGAACCGCGAAGCAGCTCTGGCCCGGCTGGTGGCTATGATTAAAGAATTAACAACA
GAAAAAAAAGCCCGACGACCCACGCGGCCCACCCGTGCATCGAAAGAGCGCAGGCTGGCA
TCGAAAGCACAAAAATCAAGCGTGAAGGCGATGCGCGGCAAAGTGCGCAGCGGTCGGGAA
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:140
Protein Molecular Weight:15473
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>L-fucose mutarotase
MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPL
FELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAI
VITGERAKYGNILLKKGVTP
References
External Links:
ResourceLink
Uniprot ID:P0AEN8
Uniprot Name:FUCM_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674377
Ecogene ID:EG10355
Ecocyc:EG10355
ColiBase:b2804
Kegg Gene:b2804
EchoBASE ID:EB0350
CCDB:FUCM_ECOLI
BacMap:16130711
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kim, M. S., Shin, J., Lee, W., Lee, H. S., Oh, B. H. (2003). "Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture." J Biol Chem 278:28173-28180. Pubmed: 12738765
  • Lu, Z., Lin, E. C. (1989). "The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation." Nucleic Acids Res 17:4883-4884. Pubmed: 2664711
  • Ryu, K. S., Kim, C., Kim, I., Yoo, S., Choi, B. S., Park, C. (2004). "NMR application probes a novel and ubiquitous family of enzymes that alter monosaccharide configuration." J Biol Chem 279:25544-25548. Pubmed: 15060078