| Identification |
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| Name: | Serine endoprotease DegS |
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| Synonyms: | Not Available |
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| Gene Name: | degS |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | proteolysis |
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| Specific Function: | A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and stress-induced degradation of RseA. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cellular response to misfolded protein | | integral component of external side of plasma membrane | | peptidase activity | | proteolysis | | serine-type endopeptidase activity | | serine-type peptidase activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1068
atgtttgtgaagctcttacgttccgttgcgattggattaattgtcggcgctattctgctg
gttgccatgccttcgctgcgcagccttaacccgctttccactccgcaatttgacagtacc
gatgagacgcctgccagctataatctggcggttcgccgcgccgcgccagcggtggttaac
gtttacaaccgtggtttgaacaccaactctcacaaccagcttgagatccgcaccctggga
tccggtgtaatcatggatcaacgcggttatatcatcaccaataaacacgtcatcaacgac
gccgatcagatcatcgtcgccttacaggatggacgtgtatttgaagcattgctggtggga
tctgactctctaaccgatctggcggtacttaaaattaatgccactggcggtttacctacc
attccaattaatgcacgtcgcgtaccgcacattggcgacgtagtactggcgatcggtaac
ccgtacaacctcgggcagaccattacccaggggattattagtgccacgggtcgaatcggt
ctgaacccgaccgggcggcaaaacttcctccaaaccgatgcttccattaaccacggtaac
tctggcggcgcgctggtgaactcgctgggcgaactgatgggcattaatacgctgtcgttt
gataagagtaacgatggcgaaacgccggaaggtatcggctttgcgattcctttccagtta
gcaaccaaaattatggataagctgatccgcgatggtcgcgtgatccgcggctacattggt
atcggcggacgtgagatcgcaccactgcacgcgcagggcggtggtatagatcaactgcaa
gggatcgtggttaatgaagtgtcacctgacggcccggcggcgaatgcgggtattcaggtc
aacgatctgattatttcggtggataacaaaccggccatctctgctctggagacgatggat
caggtggcggaaattcgccctggttcggtgatccctgtagtagtgatgcgtgatgataag
cagttaacgctgcaggtcaccattcaggaatatccggcaaccaattaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 355 |
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| Protein Molecular Weight: | 37580 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1SOT |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Serine endoprotease DegS
MFVKLLRSVAIGLIVGAILLVAMPSLRSLNPLSTPQFDSTDETPASYNLAVRRAAPAVVN
VYNRGLNTNSHNQLEIRTLGSGVIMDQRGYIITNKHVINDADQIIVALQDGRVFEALLVG
SDSLTDLAVLKINATGGLPTIPINARRVPHIGDVVLAIGNPYNLGQTITQGIISATGRIG
LNPTGRQNFLQTDASINHGNSGGALVNSLGELMGINTLSFDKSNDGETPEGIGFAIPFQL
ATKIMDKLIRDGRVIRGYIGIGGREIAPLHAQGGGIDQLQGIVVNEVSPDGPAANAGIQV
NDLIISVDNKPAISALETMDQVAEIRPGSVIPVVVMRDDKQLTLQVTIQEYPATN |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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