| Identification |
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| Name: | Transcriptional regulatory protein CpxR |
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| Synonyms: | Not Available |
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| Gene Name: | cpxR |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | - Cationic antimicrobial peptide (CAMP) resistance eco01503
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| Metabolites: | |
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| GO Classification: | | Function |
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| cytoplasm | | DNA binding | | negative regulation of transcription, DNA-templated | | phosphorelay signal transduction system | | positive regulation of transcription, DNA-templated | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >699
atgaataaaatcctgttagttgatgatgaccgagagctgacttccctattaaaggagctg
ctcgagatggaaggcttcaacgtgattgttgcccacgatggggaacaggcgcttgatctt
ctggacgacagcattgatttacttttgcttgacgtaatgatgccgaagaaaaatggtatc
gacacattaaaagcacttcgccagacacaccagacgcctgtcattatgttgacggcgcgc
ggcagtgaacttgatcgcgttctcggccttgagctgggcgcagatgactatctcccgaaa
ccgtttaatgatcgtgagctggtggcacgtattcgcgcgatcctgcgccgttcgcactgg
agcgagcaacagcaaaacaacgacaacggttcaccgacactggaagttgatgccttagtg
ctgaatccaggccgtcaggaagccagcttcgacgggcaaacgctggagttaaccggtact
gagtttaccctgctctatttgctggcacagcatctgggtcaggtggtttcccgtgaacat
ttaagccaggaagtgttgggcaaacgcctgacgcctttcgaccgcgctattgatatgcac
atttccaacctgcgtcgtaaactgccggatcgtaaagatggtcacccgtggtttaaaacc
ttgcgtggtcgcggctatctgatggtttctgcttcatga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 232 |
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| Protein Molecular Weight: | 26311 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Transcriptional regulatory protein CpxR
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGI
DTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
SEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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